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Dietary fiber intake and stroke risk: a meta-analysis of prospective cohort studies.
Eur J Clin Nutr 2013; 67(1):96-100EJ

Abstract

BACKGROUND/OBJECTIVES

Epidemiological studies have suggested that dietary fiber intake may be associated with a decreased risk of stroke, but the findings have been inconsistent. We aimed to assess this association by conducting a meta-analysis of prospective cohort studies.

SUBJECTS/METHODS

We performed a literature search on PubMed database through July 2012 to identify prospective studies of dietary fiber intake in relation to risk of stroke. We also comprehensively reviewed the reference lists of the retrieved articles to identify additional studies. We used a random-effects model to compute the summary risk estimates.

RESULTS

Six prospective cohort studies containing a total of 314 864 subjects and 8920 stroke cases were included. The summary relative risk (RR) of stroke for the highest vs lowest category of dietary fiber intake was 0.87 (95% confidence interval (CI), 0.77-0.99). The corresponding RR in the subgroup analyses for men and women was 0.95 (95% CI, 0.83-1.08) and 0.80 (95% CI, 0.66-0.96), respectively; and for ischemic stroke and hemorrhagic stroke was 0.83(95% CI, 0.72-0.96) and 0.86 (95% CI, 0.70-1.06), respectively. Meta-regression indicated no significant difference between gender (P-interaction=0.18), or stroke subtypes (P-interaction =0.85). The dose-response analysis suggested a 12% (RR=0.88; 95% CI, 0.79-0.97) reduction in risk of stroke for each 10 g per day increment in dietary fiber intake. Moderate heterogeneity emerged in some of analyses, but disappeared after removing one study substantially contributing to the heterogeneity. Little evidence of publication bias was detected.

CONCLUSION

Findings of this meta-analysis indicate a significant inverse dose-response relationship between dietary fiber intake and risk of stroke.

Authors+Show Affiliations

Department of Epidemiology, School of Public Health, Soochow University, Suzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23073261

Citation

Chen, G-C, et al. "Dietary Fiber Intake and Stroke Risk: a Meta-analysis of Prospective Cohort Studies." European Journal of Clinical Nutrition, vol. 67, no. 1, 2013, pp. 96-100.
Chen GC, Lv DB, Pang Z, et al. Dietary fiber intake and stroke risk: a meta-analysis of prospective cohort studies. Eur J Clin Nutr. 2013;67(1):96-100.
Chen, G. C., Lv, D. B., Pang, Z., Dong, J. Y., & Liu, Q. F. (2013). Dietary fiber intake and stroke risk: a meta-analysis of prospective cohort studies. European Journal of Clinical Nutrition, 67(1), pp. 96-100. doi:10.1038/ejcn.2012.158.
Chen GC, et al. Dietary Fiber Intake and Stroke Risk: a Meta-analysis of Prospective Cohort Studies. Eur J Clin Nutr. 2013;67(1):96-100. PubMed PMID: 23073261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fiber intake and stroke risk: a meta-analysis of prospective cohort studies. AU - Chen,G-C, AU - Lv,D-B, AU - Pang,Z, AU - Dong,J-Y, AU - Liu,Q-F, Y1 - 2012/10/17/ PY - 2012/10/18/entrez PY - 2012/10/18/pubmed PY - 2013/6/26/medline SP - 96 EP - 100 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 67 IS - 1 N2 - BACKGROUND/OBJECTIVES: Epidemiological studies have suggested that dietary fiber intake may be associated with a decreased risk of stroke, but the findings have been inconsistent. We aimed to assess this association by conducting a meta-analysis of prospective cohort studies. SUBJECTS/METHODS: We performed a literature search on PubMed database through July 2012 to identify prospective studies of dietary fiber intake in relation to risk of stroke. We also comprehensively reviewed the reference lists of the retrieved articles to identify additional studies. We used a random-effects model to compute the summary risk estimates. RESULTS: Six prospective cohort studies containing a total of 314 864 subjects and 8920 stroke cases were included. The summary relative risk (RR) of stroke for the highest vs lowest category of dietary fiber intake was 0.87 (95% confidence interval (CI), 0.77-0.99). The corresponding RR in the subgroup analyses for men and women was 0.95 (95% CI, 0.83-1.08) and 0.80 (95% CI, 0.66-0.96), respectively; and for ischemic stroke and hemorrhagic stroke was 0.83(95% CI, 0.72-0.96) and 0.86 (95% CI, 0.70-1.06), respectively. Meta-regression indicated no significant difference between gender (P-interaction=0.18), or stroke subtypes (P-interaction =0.85). The dose-response analysis suggested a 12% (RR=0.88; 95% CI, 0.79-0.97) reduction in risk of stroke for each 10 g per day increment in dietary fiber intake. Moderate heterogeneity emerged in some of analyses, but disappeared after removing one study substantially contributing to the heterogeneity. Little evidence of publication bias was detected. CONCLUSION: Findings of this meta-analysis indicate a significant inverse dose-response relationship between dietary fiber intake and risk of stroke. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/23073261/Dietary_fiber_intake_and_stroke_risk:_a_meta_analysis_of_prospective_cohort_studies_ L2 - http://dx.doi.org/10.1038/ejcn.2012.158 DB - PRIME DP - Unbound Medicine ER -