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[Results of intrathecal baclofen therapy on spasticity in patients with brain injury].
Ideggyogy Sz 2012; 65(7-8):243-8; discussion 248IS

Abstract

OBJECTIVES

To evaluate the results of intrathecal baclofen (ITB) therapy on the spasticity in patients with brain injury.

METHOD

Retrospective study in Brain Injury Rehabilitation Unit between January 2001 and December 2010.

RESULTS

During the last ten years, in our unit 13 patients were involved into ITB therapy on severe spasticity, after brain injury, while more than 100 Baclofen pumps were implantated in Hungary with coordination of the Multidisciplinary Team. ITB therapy was indicated in severe spasticity that developed in seven cases of traumatic brain injuries, five cases of strokes and one case of anoxic brain injury. The mean age of patients was 26 years (18-52). At the time of pump implantation three patients were in vegetative state. The shortest period elapsed between the brain injury and pump implantation was three months and the longest period was nine years, mean 15 months. Baclofen pump had to be changed in six cases after six years, and was removed in three cases due to decreasing spasticity. Catheter revision was performed in two cases due to flow problem. We had no complication in association with ITB therapy.

CONCLUSIONS

Intrathecal baclofen therapy seems to be an effective and safe treatment in patients with severe spasticity of cerebral origin. We suggest team (neurosurgeon and rehabilitation professionals) decision in a spasticity center before involving the patient into ITB therapy, and follow up in the rehabilitation unit. The severity of spasticity as a consequence of brain injury can change during years and it is necessery to follow it with dosage and dynamics of baclofen therapy. Baclofen pump removal is suggested if the ITB therapy is further not reasonable.

Authors+Show Affiliations

Országos Orvosi Rehábilitációs Intézet, Koponya-agysérültek Rehabilitációs Osztálya, 1528 Budapest. z.denes@rehabint.huNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

hun

PubMed ID

23074844

Citation

Dénes, Zoltán, et al. "[Results of Intrathecal Baclofen Therapy On Spasticity in Patients With Brain Injury]." Ideggyogyaszati Szemle, vol. 65, no. 7-8, 2012, pp. 243-8; discussion 248.
Dénes Z, Klauber A, Both B, et al. [Results of intrathecal baclofen therapy on spasticity in patients with brain injury]. Ideggyogy Sz. 2012;65(7-8):243-8; discussion 248.
Dénes, Z., Klauber, A., Both, B., & Lóránd, E. (2012). [Results of intrathecal baclofen therapy on spasticity in patients with brain injury]. Ideggyogyaszati Szemle, 65(7-8), pp. 243-8; discussion 248.
Dénes Z, et al. [Results of Intrathecal Baclofen Therapy On Spasticity in Patients With Brain Injury]. Ideggyogy Sz. 2012 Jul 30;65(7-8):243-8; discussion 248. PubMed PMID: 23074844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Results of intrathecal baclofen therapy on spasticity in patients with brain injury]. AU - Dénes,Zoltán, AU - Klauber,András, AU - Both,Béla, AU - Lóránd,Erőss, PY - 2012/10/19/entrez PY - 2012/10/19/pubmed PY - 2012/11/14/medline SP - 243-8; discussion 248 JF - Ideggyogyaszati szemle JO - Ideggyogy Sz VL - 65 IS - 7-8 N2 - OBJECTIVES: To evaluate the results of intrathecal baclofen (ITB) therapy on the spasticity in patients with brain injury. METHOD: Retrospective study in Brain Injury Rehabilitation Unit between January 2001 and December 2010. RESULTS: During the last ten years, in our unit 13 patients were involved into ITB therapy on severe spasticity, after brain injury, while more than 100 Baclofen pumps were implantated in Hungary with coordination of the Multidisciplinary Team. ITB therapy was indicated in severe spasticity that developed in seven cases of traumatic brain injuries, five cases of strokes and one case of anoxic brain injury. The mean age of patients was 26 years (18-52). At the time of pump implantation three patients were in vegetative state. The shortest period elapsed between the brain injury and pump implantation was three months and the longest period was nine years, mean 15 months. Baclofen pump had to be changed in six cases after six years, and was removed in three cases due to decreasing spasticity. Catheter revision was performed in two cases due to flow problem. We had no complication in association with ITB therapy. CONCLUSIONS: Intrathecal baclofen therapy seems to be an effective and safe treatment in patients with severe spasticity of cerebral origin. We suggest team (neurosurgeon and rehabilitation professionals) decision in a spasticity center before involving the patient into ITB therapy, and follow up in the rehabilitation unit. The severity of spasticity as a consequence of brain injury can change during years and it is necessery to follow it with dosage and dynamics of baclofen therapy. Baclofen pump removal is suggested if the ITB therapy is further not reasonable. SN - 0019-1442 UR - https://www.unboundmedicine.com/medline/citation/23074844/[Results_of_intrathecal_baclofen_therapy_on_spasticity_in_patients_with_brain_injury]_ L2 - http://www.diseaseinfosearch.org/result/6711 DB - PRIME DP - Unbound Medicine ER -