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Composition, anticancer, and antimicrobial activities in vitro of the heartwood essential oil of Cunninghamia lanceolata var. konishii from Taiwan.
Nat Prod Commun. 2012 Sep; 7(9):1245-7.NP

Abstract

This study investigated the chemical composition, anticancer, and antimicrobial activities in vitro of the essential oil isolated from the heartwood of Cunninghamia lanceolata var. konishii from Taiwan. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Thirty-seven compounds were identified, representing 100% of the oil. The main components identified were cedrol (58.3%), alpha-cedrene (11.8%), alpha-terpineol (4.2%) and beta-cedrene (3.5%). The oil exhibited cytotoxic activity against human lung, liver and oral cancer cells. The active source compound was cedrol. The antimicrobial activity of the oil was tested by the disc diffusion and micro-broth dilution methods against ten microbial species. The oil exhibited strong growth suppression against Gram-positive bacteria and yeast with inhibition zones of 42-50 mm to MIC values of 31.25-62.5 microg/mL, respectively. For the antimicrobial activities of the oil, the active compound was determined to be cedrol.

Authors+Show Affiliations

Su YC
Department of Forestry, National Chung Hsing University, 250 Kuo Kuang Rd., Taichung, Taiwan 402.
Hsu KP
No affiliation info available
Wang EI
No affiliation info available
Ho CL
No affiliation info available

MeSH

Anti-Infective AgentsAntineoplastic Agents, PhytogenicCell Line, TumorCunninghamiaHumansMicrobial Sensitivity TestsOils, VolatileTaiwan

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23074921

Citation

Su, Yu-Chang, et al. "Composition, Anticancer, and Antimicrobial Activities in Vitro of the Heartwood Essential Oil of Cunninghamia Lanceolata Var. Konishii From Taiwan." Natural Product Communications, vol. 7, no. 9, 2012, pp. 1245-7.
Su YC, Hsu KP, Wang EI, et al. Composition, anticancer, and antimicrobial activities in vitro of the heartwood essential oil of Cunninghamia lanceolata var. konishii from Taiwan. Nat Prod Commun. 2012;7(9):1245-7.
Su, Y. C., Hsu, K. P., Wang, E. I., & Ho, C. L. (2012). Composition, anticancer, and antimicrobial activities in vitro of the heartwood essential oil of Cunninghamia lanceolata var. konishii from Taiwan. Natural Product Communications, 7(9), 1245-7.
Su YC, et al. Composition, Anticancer, and Antimicrobial Activities in Vitro of the Heartwood Essential Oil of Cunninghamia Lanceolata Var. Konishii From Taiwan. Nat Prod Commun. 2012;7(9):1245-7. PubMed PMID: 23074921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Composition, anticancer, and antimicrobial activities in vitro of the heartwood essential oil of Cunninghamia lanceolata var. konishii from Taiwan. AU - Su,Yu-Chang, AU - Hsu,Kuan-Ping, AU - Wang,Eugene I-Chen, AU - Ho,Chen-Lung, PY - 2012/10/19/entrez PY - 2012/10/19/pubmed PY - 2012/11/6/medline SP - 1245 EP - 7 JF - Natural product communications JO - Nat Prod Commun VL - 7 IS - 9 N2 - This study investigated the chemical composition, anticancer, and antimicrobial activities in vitro of the essential oil isolated from the heartwood of Cunninghamia lanceolata var. konishii from Taiwan. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Thirty-seven compounds were identified, representing 100% of the oil. The main components identified were cedrol (58.3%), alpha-cedrene (11.8%), alpha-terpineol (4.2%) and beta-cedrene (3.5%). The oil exhibited cytotoxic activity against human lung, liver and oral cancer cells. The active source compound was cedrol. The antimicrobial activity of the oil was tested by the disc diffusion and micro-broth dilution methods against ten microbial species. The oil exhibited strong growth suppression against Gram-positive bacteria and yeast with inhibition zones of 42-50 mm to MIC values of 31.25-62.5 microg/mL, respectively. For the antimicrobial activities of the oil, the active compound was determined to be cedrol. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/23074921/Composition_anticancer_and_antimicrobial_activities_in_vitro_of_the_heartwood_essential_oil_of_Cunninghamia_lanceolata_var__konishii_from_Taiwan_ DB - PRIME DP - Unbound Medicine ER -