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Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.
N Engl J Med. 2012 Nov 08; 367(19):1814-20.NEJM

Abstract

A previously unknown coronavirus was isolated from the sputum of a 60-year-old man who presented with acute pneumonia and subsequent renal failure with a fatal outcome in Saudi Arabia. The virus (called HCoV-EMC) replicated readily in cell culture, producing cytopathic effects of rounding, detachment, and syncytium formation. The virus represents a novel betacoronavirus species. The closest known relatives are bat coronaviruses HKU4 and HKU5. Here, the clinical data, virus isolation, and molecular identification are presented. The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.

Authors+Show Affiliations

Dr Soliman Fakeeh Hospital, Jeddah, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23075143

Citation

Zaki, Ali M., et al. "Isolation of a Novel Coronavirus From a Man With Pneumonia in Saudi Arabia." The New England Journal of Medicine, vol. 367, no. 19, 2012, pp. 1814-20.
Zaki AM, van Boheemen S, Bestebroer TM, et al. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367(19):1814-20.
Zaki, A. M., van Boheemen, S., Bestebroer, T. M., Osterhaus, A. D., & Fouchier, R. A. (2012). Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. The New England Journal of Medicine, 367(19), 1814-20. https://doi.org/10.1056/NEJMoa1211721
Zaki AM, et al. Isolation of a Novel Coronavirus From a Man With Pneumonia in Saudi Arabia. N Engl J Med. 2012 Nov 8;367(19):1814-20. PubMed PMID: 23075143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. AU - Zaki,Ali M, AU - van Boheemen,Sander, AU - Bestebroer,Theo M, AU - Osterhaus,Albert D M E, AU - Fouchier,Ron A M, Y1 - 2012/10/17/ PY - 2012/10/19/entrez PY - 2012/10/19/pubmed PY - 2012/12/10/medline SP - 1814 EP - 20 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 367 IS - 19 N2 - A previously unknown coronavirus was isolated from the sputum of a 60-year-old man who presented with acute pneumonia and subsequent renal failure with a fatal outcome in Saudi Arabia. The virus (called HCoV-EMC) replicated readily in cell culture, producing cytopathic effects of rounding, detachment, and syncytium formation. The virus represents a novel betacoronavirus species. The closest known relatives are bat coronaviruses HKU4 and HKU5. Here, the clinical data, virus isolation, and molecular identification are presented. The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans. SN - 1533-4406 UR - https://www.unboundmedicine.com/medline/citation/23075143/full_citation L2 - http://www.nejm.org/doi/full/10.1056/NEJMoa1211721?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -