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Optimize dietary intake of vitamin D: an epigenetic perspective.
Curr Opin Clin Nutr Metab Care 2012; 15(6):567-79CO

Abstract

PURPOSE OF REVIEW

Vitamin D has received global attention because of its many health benefits. Although there is general agreement about the importance of vitamin D for bone health, there remains skepticism about the nonskeletal health benefits of vitamin D. This review will not only focus on the vitamin D deficiency pandemic and ways to treat and prevent vitamin D deficiency but will also explore the epigenetic mechanisms of vitamin D that could help explain many of the nonskeletal benefits of enhancing vitamin D status.

RECENT FINDINGS

The Institute of Medicine and the Endocrine Society have made new recommendations for vitamin D intake to prevent vitamin D deficiency. Vitamin D deficiency is defined as a 25-hydroxyvitamin D level below 20 ng/ml and vitamin D insufficiency is defined as 21-29 ng/ml. Recent observations have suggested that vitamin D can influence epigenetics which may help explain the nonskeletal health benefits that have been reported for vitamin D.

SUMMARY

There is general agreement that vitamin D deficiency is a worldwide health problem. This is due in part to the lack of appreciation that sunlight is an important source of vitamin D. There is no downside to increasing vitamin D intake and recent observations suggesting that vitamin D influences epigenetics provide a new insight for the importance of vitamin D in utero in reducing risk of chronic diseases later in life.

Authors+Show Affiliations

Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23075936

Citation

Hossein-nezhad, Arash, and Michael F. Holick. "Optimize Dietary Intake of Vitamin D: an Epigenetic Perspective." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 15, no. 6, 2012, pp. 567-79.
Hossein-nezhad A, Holick MF. Optimize dietary intake of vitamin D: an epigenetic perspective. Curr Opin Clin Nutr Metab Care. 2012;15(6):567-79.
Hossein-nezhad, A., & Holick, M. F. (2012). Optimize dietary intake of vitamin D: an epigenetic perspective. Current Opinion in Clinical Nutrition and Metabolic Care, 15(6), pp. 567-79. doi:10.1097/MCO.0b013e3283594978.
Hossein-nezhad A, Holick MF. Optimize Dietary Intake of Vitamin D: an Epigenetic Perspective. Curr Opin Clin Nutr Metab Care. 2012;15(6):567-79. PubMed PMID: 23075936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimize dietary intake of vitamin D: an epigenetic perspective. AU - Hossein-nezhad,Arash, AU - Holick,Michael F, PY - 2012/10/19/entrez PY - 2012/10/19/pubmed PY - 2013/3/28/medline SP - 567 EP - 79 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 15 IS - 6 N2 - PURPOSE OF REVIEW: Vitamin D has received global attention because of its many health benefits. Although there is general agreement about the importance of vitamin D for bone health, there remains skepticism about the nonskeletal health benefits of vitamin D. This review will not only focus on the vitamin D deficiency pandemic and ways to treat and prevent vitamin D deficiency but will also explore the epigenetic mechanisms of vitamin D that could help explain many of the nonskeletal benefits of enhancing vitamin D status. RECENT FINDINGS: The Institute of Medicine and the Endocrine Society have made new recommendations for vitamin D intake to prevent vitamin D deficiency. Vitamin D deficiency is defined as a 25-hydroxyvitamin D level below 20 ng/ml and vitamin D insufficiency is defined as 21-29 ng/ml. Recent observations have suggested that vitamin D can influence epigenetics which may help explain the nonskeletal health benefits that have been reported for vitamin D. SUMMARY: There is general agreement that vitamin D deficiency is a worldwide health problem. This is due in part to the lack of appreciation that sunlight is an important source of vitamin D. There is no downside to increasing vitamin D intake and recent observations suggesting that vitamin D influences epigenetics provide a new insight for the importance of vitamin D in utero in reducing risk of chronic diseases later in life. SN - 1473-6519 UR - https://www.unboundmedicine.com/medline/citation/23075936/Optimize_dietary_intake_of_vitamin_D:_an_epigenetic_perspective_ L2 - http://Insights.ovid.com/pubmed?pmid=23075936 DB - PRIME DP - Unbound Medicine ER -