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Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
Am J Clin Nutr 2012; 96(6):1398-408AJ

Abstract

BACKGROUND

Several experimental studies have suggested potential anticarcinogenic effects of flavonoids, although epidemiologic evidence for the impact of dietary flavonoids on risk of gastric cancer (GC) is limited.

OBJECTIVE

We investigated the association between intake of dietary flavonoids and lignans and incident GC.

DESIGN

The study followed 477,312 subjects (29.8% men) aged 35-70 y from 10 European countries who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Validated dietary questionnaires and lifestyle information were collected at baseline. A food-composition database on flavonoids and lignans was compiled by using data from USDA and Phenol-Explorer databases.

RESULTS

During an average follow-up of 11 y, 683 incident GC cases (57.8% men) were mostly validated by a panel of pathologists and used in this analysis. We observed a significant inverse association between total flavonoid intake and GC risk in women (HR: 0.81; 95% CI: 0.70, 0.94; for the continuous variable after log₂ transformation) but not in men (HR: 0.97; 95% CI: 0.85, 1.09). In women, significant inverse associations with GC risk were also observed for intakes of some flavonoid subgroups (anthocyanidins, flavonols, flavones, and flavanols), particularly with intestinal type tumors for total flavonoid and flavanol intakes (P-heterogeneity < 0.1). After stratification by smoking status and sex, there was no significant heterogeneity in these associations between ever- and never-smokers.

CONCLUSION

Total dietary flavonoid intake is associated with a significant reduction in the risk of GC in women.

Authors+Show Affiliations

Unit of Nutrition, Environment, and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Barcelona, Spain. rzamora@iconcologia.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23076618

Citation

Zamora-Ros, Raul, et al. "Dietary Flavonoid and Lignan Intake and Gastric Adenocarcinoma Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study." The American Journal of Clinical Nutrition, vol. 96, no. 6, 2012, pp. 1398-408.
Zamora-Ros R, Agudo A, Luján-Barroso L, et al. Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am J Clin Nutr. 2012;96(6):1398-408.
Zamora-Ros, R., Agudo, A., Luján-Barroso, L., Romieu, I., Ferrari, P., Knaze, V., ... González, C. A. (2012). Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The American Journal of Clinical Nutrition, 96(6), pp. 1398-408. doi:10.3945/ajcn.112.037358.
Zamora-Ros R, et al. Dietary Flavonoid and Lignan Intake and Gastric Adenocarcinoma Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study. Am J Clin Nutr. 2012;96(6):1398-408. PubMed PMID: 23076618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. AU - Zamora-Ros,Raul, AU - Agudo,Antonio, AU - Luján-Barroso,Leila, AU - Romieu,Isabelle, AU - Ferrari,Pietro, AU - Knaze,Viktoria, AU - Bueno-de-Mesquita,H Bas, AU - Leenders,Max, AU - Travis,Ruth C, AU - Navarro,Carmen, AU - Sánchez-Cantalejo,Emilio, AU - Slimani,Nadia, AU - Scalbert,Augustin, AU - Fedirko,Veronika, AU - Hjartåker,Anette, AU - Engeset,Dagrun, AU - Skeie,Guri, AU - Boeing,Heiner, AU - Förster,Jana, AU - Li,Kuanrong, AU - Teucher,Birgit, AU - Agnoli,Claudia, AU - Tumino,Rosario, AU - Mattiello,Amalia, AU - Saieva,Calogero, AU - Johansson,Ingegerd, AU - Stenling,Roger, AU - Redondo,Maria Luisa, AU - Wallström,Peter, AU - Ericson,Ulrika, AU - Khaw,Kay-Tee, AU - Mulligan,Angela A, AU - Trichopoulou,Antonia, AU - Dilis,Vardis, AU - Katsoulis,Michael, AU - Peeters,Petra H M, AU - Igali,Lazslo, AU - Tjønneland,Anne, AU - Halkjær,Jytte, AU - Touillaud,Marina, AU - Perquier,Florence, AU - Fagherazzi,Guy, AU - Amiano,Pilar, AU - Ardanaz,Eva, AU - Bredsdorff,Lea, AU - Overvad,Kim, AU - Ricceri,Fulvio, AU - Riboli,Elio, AU - González,Carlos A, Y1 - 2012/10/17/ PY - 2012/10/19/entrez PY - 2012/10/19/pubmed PY - 2013/1/26/medline SP - 1398 EP - 408 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 96 IS - 6 N2 - BACKGROUND: Several experimental studies have suggested potential anticarcinogenic effects of flavonoids, although epidemiologic evidence for the impact of dietary flavonoids on risk of gastric cancer (GC) is limited. OBJECTIVE: We investigated the association between intake of dietary flavonoids and lignans and incident GC. DESIGN: The study followed 477,312 subjects (29.8% men) aged 35-70 y from 10 European countries who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Validated dietary questionnaires and lifestyle information were collected at baseline. A food-composition database on flavonoids and lignans was compiled by using data from USDA and Phenol-Explorer databases. RESULTS: During an average follow-up of 11 y, 683 incident GC cases (57.8% men) were mostly validated by a panel of pathologists and used in this analysis. We observed a significant inverse association between total flavonoid intake and GC risk in women (HR: 0.81; 95% CI: 0.70, 0.94; for the continuous variable after log₂ transformation) but not in men (HR: 0.97; 95% CI: 0.85, 1.09). In women, significant inverse associations with GC risk were also observed for intakes of some flavonoid subgroups (anthocyanidins, flavonols, flavones, and flavanols), particularly with intestinal type tumors for total flavonoid and flavanol intakes (P-heterogeneity < 0.1). After stratification by smoking status and sex, there was no significant heterogeneity in these associations between ever- and never-smokers. CONCLUSION: Total dietary flavonoid intake is associated with a significant reduction in the risk of GC in women. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/23076618/Dietary_flavonoid_and_lignan_intake_and_gastric_adenocarcinoma_risk_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC__study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.037358 DB - PRIME DP - Unbound Medicine ER -