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Hippocampal place cells can encode multiple trial-dependent features through rate remapping.
J Neurosci. 2012 Oct 17; 32(42):14752-66.JN

Abstract

The activity of hippocampal pyramidal cells reflects both the current position of the animal and information related to its current behavior. Here we investigated whether single hippocampal neurons can encode several independent features defining trials during a memory task. We also tested whether task-related information is represented by partial remapping of the place cell population or, instead, via firing rate modulation of spatially stable place cells. To address these two questions, the activity of hippocampal neurons was recorded in rats performing a conditional discrimination task on a modified T-maze in which the identity of a food reward guided behavior. When the rat was on the central arm of the maze, the firing rate of pyramidal cells changed depending on two independent factors: (1) the identity of the food reward given to the animal and (2) the previous location of the animal on the maze. Importantly, some pyramidal cells encoded information relative to both factors. This trial-type specific and retrospective coding did not interfere with the spatial representation of the maze: hippocampal cells had stable place fields and their theta-phase precession profiles were unaltered during the task, indicating that trial-related information was encoded via rate remapping. During error trials, encoding of both trial-related information and spatial location was impaired. Finally, we found that pyramidal cells also encode trial-related information via rate remapping during the continuous version of the rewarded alternation task without delays. These results suggest that hippocampal neurons can encode several task-related cognitive aspects via rate remapping.

Authors+Show Affiliations

MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford, OX1 3TH, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23077060

Citation

Allen, Kevin, et al. "Hippocampal Place Cells Can Encode Multiple Trial-dependent Features Through Rate Remapping." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, vol. 32, no. 42, 2012, pp. 14752-66.
Allen K, Rawlins JN, Bannerman DM, et al. Hippocampal place cells can encode multiple trial-dependent features through rate remapping. J Neurosci. 2012;32(42):14752-66.
Allen, K., Rawlins, J. N., Bannerman, D. M., & Csicsvari, J. (2012). Hippocampal place cells can encode multiple trial-dependent features through rate remapping. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32(42), 14752-66. https://doi.org/10.1523/JNEUROSCI.6175-11.2012
Allen K, et al. Hippocampal Place Cells Can Encode Multiple Trial-dependent Features Through Rate Remapping. J Neurosci. 2012 Oct 17;32(42):14752-66. PubMed PMID: 23077060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal place cells can encode multiple trial-dependent features through rate remapping. AU - Allen,Kevin, AU - Rawlins,J Nick P, AU - Bannerman,David M, AU - Csicsvari,Jozsef, PY - 2012/10/19/entrez PY - 2012/10/19/pubmed PY - 2013/1/3/medline SP - 14752 EP - 66 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience JO - J Neurosci VL - 32 IS - 42 N2 - The activity of hippocampal pyramidal cells reflects both the current position of the animal and information related to its current behavior. Here we investigated whether single hippocampal neurons can encode several independent features defining trials during a memory task. We also tested whether task-related information is represented by partial remapping of the place cell population or, instead, via firing rate modulation of spatially stable place cells. To address these two questions, the activity of hippocampal neurons was recorded in rats performing a conditional discrimination task on a modified T-maze in which the identity of a food reward guided behavior. When the rat was on the central arm of the maze, the firing rate of pyramidal cells changed depending on two independent factors: (1) the identity of the food reward given to the animal and (2) the previous location of the animal on the maze. Importantly, some pyramidal cells encoded information relative to both factors. This trial-type specific and retrospective coding did not interfere with the spatial representation of the maze: hippocampal cells had stable place fields and their theta-phase precession profiles were unaltered during the task, indicating that trial-related information was encoded via rate remapping. During error trials, encoding of both trial-related information and spatial location was impaired. Finally, we found that pyramidal cells also encode trial-related information via rate remapping during the continuous version of the rewarded alternation task without delays. These results suggest that hippocampal neurons can encode several task-related cognitive aspects via rate remapping. SN - 1529-2401 UR - https://www.unboundmedicine.com/medline/citation/23077060/Hippocampal_place_cells_can_encode_multiple_trial_dependent_features_through_rate_remapping_ L2 - http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=23077060 DB - PRIME DP - Unbound Medicine ER -