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Obesity phenotype and incident hypertension: a prospective community-based cohort study.
J Hypertens. 2013 Jan; 31(1):145-51.JH

Abstract

OBJECTIVE

The relationship betweens the healthy obese phenotype and the risk of cardiovascular events remains unclear. We prospectively investigated the association between the obesity phenotype and the incidence of hypertension.

METHODS

We studied 2352 participants, aged 40-69 years at baseline, with normal blood pressure (BP) from the Ansan cohort and the Ansung cohort of the Korean Genome Epidemiology Study. Participants were divided into six groups based on BMI and the metabolic syndrome (MetS) components: healthy (none of the five MetS components) normal weight (BMI <23 kg/m(2)), unhealthy (one or more MetS component) normal weight, healthy overweight (BMI 23-24.9 kg/m(2)), unhealthy overweight, healthy obesity (BMI ≥25 kg/m(2)), and unhealthy obesity. The incidence of hypertension was identified by biennial health examinations during the 8-year follow-up.

RESULTS

After adjusting for age, sex, cohort, physical activity, smoking, alcohol consumption, and family history of hypertension and cardiovascular diseases, an increased risk for hypertension in combined cohort was observed in the healthy obesity [hazard ratio (HR): 2.20, 95% confidence interval (CI):1.34-3.60], unhealthy overweight (HR: 1.47, 95% CI: 1.00-2.14), and unhealthy obesity (HR: 2.45, 95% CI: 1.79-3.37), compared with the healthy normal weight group. In each cohort, the healthy obesity was still associated with a higher incidence of hypertension (HR 2.20, 95% CI 1.11-4.36 for the Ansan cohort and HR 2.21, 95% CI 1.01-4.83 for the Ansung cohort).

CONCLUSION

These findings provide evidence that the metabolically healthy obese phenotype may not be a benign condition.

Authors+Show Affiliations

Institute of Human Genomic Study, Ansan, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23079679

Citation

Lee, Seung Ku, et al. "Obesity Phenotype and Incident Hypertension: a Prospective Community-based Cohort Study." Journal of Hypertension, vol. 31, no. 1, 2013, pp. 145-51.
Lee SK, Kim SH, Cho GY, et al. Obesity phenotype and incident hypertension: a prospective community-based cohort study. J Hypertens. 2013;31(1):145-51.
Lee, S. K., Kim, S. H., Cho, G. Y., Baik, I., Lim, H. E., Park, C. G., Lee, J. B., Kim, Y. H., Lim, S. Y., Kim, H., & Shin, C. (2013). Obesity phenotype and incident hypertension: a prospective community-based cohort study. Journal of Hypertension, 31(1), 145-51. https://doi.org/10.1097/HJH.0b013e32835a3637
Lee SK, et al. Obesity Phenotype and Incident Hypertension: a Prospective Community-based Cohort Study. J Hypertens. 2013;31(1):145-51. PubMed PMID: 23079679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity phenotype and incident hypertension: a prospective community-based cohort study. AU - Lee,Seung Ku, AU - Kim,Seong Hwan, AU - Cho,Goo-Yeong, AU - Baik,Inkyung, AU - Lim,Hong Euy, AU - Park,Chang Gyu, AU - Lee,Jung Bok, AU - Kim,Yong Hyun, AU - Lim,Sang Yup, AU - Kim,Hyun, AU - Shin,Chol, PY - 2012/10/20/entrez PY - 2012/10/20/pubmed PY - 2013/7/9/medline SP - 145 EP - 51 JF - Journal of hypertension JO - J. Hypertens. VL - 31 IS - 1 N2 - OBJECTIVE: The relationship betweens the healthy obese phenotype and the risk of cardiovascular events remains unclear. We prospectively investigated the association between the obesity phenotype and the incidence of hypertension. METHODS: We studied 2352 participants, aged 40-69 years at baseline, with normal blood pressure (BP) from the Ansan cohort and the Ansung cohort of the Korean Genome Epidemiology Study. Participants were divided into six groups based on BMI and the metabolic syndrome (MetS) components: healthy (none of the five MetS components) normal weight (BMI <23 kg/m(2)), unhealthy (one or more MetS component) normal weight, healthy overweight (BMI 23-24.9 kg/m(2)), unhealthy overweight, healthy obesity (BMI ≥25 kg/m(2)), and unhealthy obesity. The incidence of hypertension was identified by biennial health examinations during the 8-year follow-up. RESULTS: After adjusting for age, sex, cohort, physical activity, smoking, alcohol consumption, and family history of hypertension and cardiovascular diseases, an increased risk for hypertension in combined cohort was observed in the healthy obesity [hazard ratio (HR): 2.20, 95% confidence interval (CI):1.34-3.60], unhealthy overweight (HR: 1.47, 95% CI: 1.00-2.14), and unhealthy obesity (HR: 2.45, 95% CI: 1.79-3.37), compared with the healthy normal weight group. In each cohort, the healthy obesity was still associated with a higher incidence of hypertension (HR 2.20, 95% CI 1.11-4.36 for the Ansan cohort and HR 2.21, 95% CI 1.01-4.83 for the Ansung cohort). CONCLUSION: These findings provide evidence that the metabolically healthy obese phenotype may not be a benign condition. SN - 1473-5598 UR - https://www.unboundmedicine.com/medline/citation/23079679/Obesity_phenotype_and_incident_hypertension:_a_prospective_community_based_cohort_study_ L2 - http://dx.doi.org/10.1097/HJH.0b013e32835a3637 DB - PRIME DP - Unbound Medicine ER -