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[Clinical reference values for laboratory hematology tests calculated using the iterative truncation method with correction: Part 1. Reference values for erythrocyte count, hemoglobin quantity, hematocrit and other erythrocyte parameters including MCV, MCH, MCHC and RDW].
Rinsho Byori. 1990 Jan; 38(1):93-103.RB

Abstract

Age and sex dependent differences in the clinical reference values for erythrocyte count (RBC), hemoglobin quantity (Hb), hematocrit (Ht) and other erythrocyte parameters including MCV (mean corpuscular volume), MCH (mean corpuscular hemoglobin), MCHC (mean corpuscular hemoglobin concentration) and RDW (red cell distribution width), were calculated by the iterative truncation method with correction (Usui's method) using the results from tests on 6,300 patients' specimens obtained at Kyoto University Hospital. For RBC, Hb and Ht, the data obtained from the individuals below 13 years old showed the normal or sometimes log-normal distribution, but adjustment by the Xn-type variable transformation was often necessary to obtain the normal distribution for the data taken from the populations containing individuals over the age of 14. For the clinical reference values of RBC, Hb and Ht, no sex difference was observed below the age of 12. The values for males were significantly higher than those of females in the age range 13-79, and the values showed no significant sex-dependent difference at ages above 80. In females, age-dependent change of values for RBC, Hb and Ht was less prominent than in males; especially the upper limit values for females were very stable for all ages. MCV and MCH gradually increased with age both in males and females, and the MCHC remained constant in all age populations of male and female. The reference value for RDW was generated by the percentile method instead of the iterative truncation method because of the strong deviation in the distribution pattern, and the RDW values showed a gradual increase with age in both males and females.

Authors+Show Affiliations

Hematology Division of Central Clinical Laboratory, Kyoto University Hospital.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

2308230

Citation

Shiga, S, et al. "[Clinical Reference Values for Laboratory Hematology Tests Calculated Using the Iterative Truncation Method With Correction: Part 1. Reference Values for Erythrocyte Count, Hemoglobin Quantity, Hematocrit and Other Erythrocyte Parameters Including MCV, MCH, MCHC and RDW]." Rinsho Byori. the Japanese Journal of Clinical Pathology, vol. 38, no. 1, 1990, pp. 93-103.
Shiga S, Koyanagi I, Kannagi R. [Clinical reference values for laboratory hematology tests calculated using the iterative truncation method with correction: Part 1. Reference values for erythrocyte count, hemoglobin quantity, hematocrit and other erythrocyte parameters including MCV, MCH, MCHC and RDW]. Rinsho Byori. 1990;38(1):93-103.
Shiga, S., Koyanagi, I., & Kannagi, R. (1990). [Clinical reference values for laboratory hematology tests calculated using the iterative truncation method with correction: Part 1. Reference values for erythrocyte count, hemoglobin quantity, hematocrit and other erythrocyte parameters including MCV, MCH, MCHC and RDW]. Rinsho Byori. the Japanese Journal of Clinical Pathology, 38(1), 93-103.
Shiga S, Koyanagi I, Kannagi R. [Clinical Reference Values for Laboratory Hematology Tests Calculated Using the Iterative Truncation Method With Correction: Part 1. Reference Values for Erythrocyte Count, Hemoglobin Quantity, Hematocrit and Other Erythrocyte Parameters Including MCV, MCH, MCHC and RDW]. Rinsho Byori. 1990;38(1):93-103. PubMed PMID: 2308230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical reference values for laboratory hematology tests calculated using the iterative truncation method with correction: Part 1. Reference values for erythrocyte count, hemoglobin quantity, hematocrit and other erythrocyte parameters including MCV, MCH, MCHC and RDW]. AU - Shiga,S, AU - Koyanagi,I, AU - Kannagi,R, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 93 EP - 103 JF - Rinsho byori. The Japanese journal of clinical pathology JO - Rinsho Byori VL - 38 IS - 1 N2 - Age and sex dependent differences in the clinical reference values for erythrocyte count (RBC), hemoglobin quantity (Hb), hematocrit (Ht) and other erythrocyte parameters including MCV (mean corpuscular volume), MCH (mean corpuscular hemoglobin), MCHC (mean corpuscular hemoglobin concentration) and RDW (red cell distribution width), were calculated by the iterative truncation method with correction (Usui's method) using the results from tests on 6,300 patients' specimens obtained at Kyoto University Hospital. For RBC, Hb and Ht, the data obtained from the individuals below 13 years old showed the normal or sometimes log-normal distribution, but adjustment by the Xn-type variable transformation was often necessary to obtain the normal distribution for the data taken from the populations containing individuals over the age of 14. For the clinical reference values of RBC, Hb and Ht, no sex difference was observed below the age of 12. The values for males were significantly higher than those of females in the age range 13-79, and the values showed no significant sex-dependent difference at ages above 80. In females, age-dependent change of values for RBC, Hb and Ht was less prominent than in males; especially the upper limit values for females were very stable for all ages. MCV and MCH gradually increased with age both in males and females, and the MCHC remained constant in all age populations of male and female. The reference value for RDW was generated by the percentile method instead of the iterative truncation method because of the strong deviation in the distribution pattern, and the RDW values showed a gradual increase with age in both males and females. SN - 0047-1860 UR - https://www.unboundmedicine.com/medline/citation/2308230/[Clinical_reference_values_for_laboratory_hematology_tests_calculated_using_the_iterative_truncation_method_with_correction:_Part_1__Reference_values_for_erythrocyte_count_hemoglobin_quantity_hematocrit_and_other_erythrocyte_parameters_including_MCV_MCH_MCHC_and_RDW]_ DB - PRIME DP - Unbound Medicine ER -