Tags

Type your tag names separated by a space and hit enter

Soy protein with or without isoflavones failed to preserve bone density in gonadal hormone-deficient male rat model of osteoporosis.
Nutr Res. 2012 Sep; 32(9):694-700.NR

Abstract

Soy with its isoflavones has been shown to positively influence bone mineral density in female ovariectomized rats; hence, we hypothesized a similar effect in orchidectomized (ORX) male rats. Forty male Sprague-Dawley rats, aged 95 days, were divided into 4 groups and were either sham operated (Sham) or ORX. The ORX groups were fed a soy protein-based diet (SOY), an isoflavone-depleted soy protein diet (SOY-), or a casein based diet for 65 days after surgery. Orchidectomy increased the rate of bone turnover, resulting in reduced bone mineral density and bone mineral content by 3.5% and 14%, respectively, and compromised biomechanical properties. The mean femoral length of ORX animals was also significantly shorter than Sham animals, but ORX rats that were fed SOY diet did not experience this reduction in bone length, implicating a role for soy protein in bone growth (4.02 ± 0.02, 3.93 ± 0.01, 3.99 ± 0.02, 3.91 ± 0.01 for Sham, ORX, SOY, SOY-, respectively). The SOY and SOY- positively influenced the biomechanical properties of bone such as yield and ultimate force, the measures of bone elasticity, and plasticity. In terms of bone histomorphometry, the data indicate that SOY- tends to reduce ORX-induced increase in bone turnover as evidenced by suppressed bone formation rate/mineralized surface by about 9%. Overall, our results indicated that soy protein, regardless of its isoflavone content, was unable to prevent the ORX-induced femoral decrease in bone density and mineral content. However, soy may enhance the quality of bone as indicated by increased yield force.

Authors+Show Affiliations

Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23084642

Citation

Juma, Shanil S., et al. "Soy Protein With or Without Isoflavones Failed to Preserve Bone Density in Gonadal Hormone-deficient Male Rat Model of Osteoporosis." Nutrition Research (New York, N.Y.), vol. 32, no. 9, 2012, pp. 694-700.
Juma SS, Ezzat-Zadeh Z, Khalil DA, et al. Soy protein with or without isoflavones failed to preserve bone density in gonadal hormone-deficient male rat model of osteoporosis. Nutr Res. 2012;32(9):694-700.
Juma, S. S., Ezzat-Zadeh, Z., Khalil, D. A., Hooshmand, S., Akhter, M., & Arjmandi, B. H. (2012). Soy protein with or without isoflavones failed to preserve bone density in gonadal hormone-deficient male rat model of osteoporosis. Nutrition Research (New York, N.Y.), 32(9), 694-700. https://doi.org/10.1016/j.nutres.2012.08.001
Juma SS, et al. Soy Protein With or Without Isoflavones Failed to Preserve Bone Density in Gonadal Hormone-deficient Male Rat Model of Osteoporosis. Nutr Res. 2012;32(9):694-700. PubMed PMID: 23084642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy protein with or without isoflavones failed to preserve bone density in gonadal hormone-deficient male rat model of osteoporosis. AU - Juma,Shanil S, AU - Ezzat-Zadeh,Zahra, AU - Khalil,Dania A, AU - Hooshmand,Shirin, AU - Akhter,Mohammed, AU - Arjmandi,Bahram H, Y1 - 2012/09/23/ PY - 2011/11/14/received PY - 2012/07/31/revised PY - 2012/08/03/accepted PY - 2012/10/23/entrez PY - 2012/10/23/pubmed PY - 2013/3/27/medline SP - 694 EP - 700 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 32 IS - 9 N2 - Soy with its isoflavones has been shown to positively influence bone mineral density in female ovariectomized rats; hence, we hypothesized a similar effect in orchidectomized (ORX) male rats. Forty male Sprague-Dawley rats, aged 95 days, were divided into 4 groups and were either sham operated (Sham) or ORX. The ORX groups were fed a soy protein-based diet (SOY), an isoflavone-depleted soy protein diet (SOY-), or a casein based diet for 65 days after surgery. Orchidectomy increased the rate of bone turnover, resulting in reduced bone mineral density and bone mineral content by 3.5% and 14%, respectively, and compromised biomechanical properties. The mean femoral length of ORX animals was also significantly shorter than Sham animals, but ORX rats that were fed SOY diet did not experience this reduction in bone length, implicating a role for soy protein in bone growth (4.02 ± 0.02, 3.93 ± 0.01, 3.99 ± 0.02, 3.91 ± 0.01 for Sham, ORX, SOY, SOY-, respectively). The SOY and SOY- positively influenced the biomechanical properties of bone such as yield and ultimate force, the measures of bone elasticity, and plasticity. In terms of bone histomorphometry, the data indicate that SOY- tends to reduce ORX-induced increase in bone turnover as evidenced by suppressed bone formation rate/mineralized surface by about 9%. Overall, our results indicated that soy protein, regardless of its isoflavone content, was unable to prevent the ORX-induced femoral decrease in bone density and mineral content. However, soy may enhance the quality of bone as indicated by increased yield force. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/23084642/Soy_protein_with_or_without_isoflavones_failed_to_preserve_bone_density_in_gonadal_hormone_deficient_male_rat_model_of_osteoporosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(12)00162-5 DB - PRIME DP - Unbound Medicine ER -