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Effectiveness of the influenza vaccine at preventing hospitalization due to acute lower respiratory infection and exacerbation of chronic cardiopulmonary disease in Korea during 2010-2011.

Abstract

BACKGROUND

Influenza epidemics are accompanied by a considerable increase in hospitalization due to acute lower respiratory infection and exacerbation of underlying medical conditions. We estimated the effectiveness of the influenza vaccine at preventing hospitalization due to acute lower respiratory infection and new onset or acute exacerbation of chronic cardiopulmonary disease.

METHOD

During the peak influenza period in 2010-2011, we performed a multicenter, case-control, retrospective cohort study of patients who were hospitalized due to newly developed pneumonia, bronchitis, and bronchiolitis, or new onset or acute exacerbation of asthma, COPD, ischemic heart disease, and CHF. Controls were selected from outpatients who visited study hospitals but who were not hospitalized during the same study period. Controls were matched 1:1 to cases based on age, gender, and date of hospital visit. Univariate and multivariate logistic regression analyses were used to determine the effectiveness of the influenza vaccine at decreasing hospitalization.

RESULTS

Between December 2010 and February 2011, 556 hospitalized subjects were identified. Age, gender, and body mass index (BMI) were similar between case and control groups. The influenza vaccination rate of the hospitalized and non-hospitalized patients was 42.4% and 52.2%, respectively (p<0.001). The overall vaccine effectiveness for preventing hospitalization was 32.5% (odds ratio 0.675, 95% confidence interval [CI] 0.486-0.937; p=0.019). Multivariate logistic analysis showed that influenza vaccination significantly reduced the risk of hospitalization, especially due to new onset or acute exacerbation of ischemic heart disease and CHF in patients aged 65 years and older (OR 0.274, 95% CI 0.114-0.658, p=0.004). The estimated vaccine effectiveness in these patients was 72.6%.

CONCLUSION

Influenza vaccination reduced the rate of hospitalization among patients with underlying chronic heart disease, particularly those patients 65 years old and greater.

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  • Authors+Show Affiliations

    ,

    Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.

    , , , , , , , ,

    Source

    Vaccine 31:10 2013 Feb 27 pg 1426-30

    MeSH

    Adult
    Aged
    Bronchopneumonia
    Case-Control Studies
    Cohort Studies
    Female
    Hospitalization
    Humans
    Influenza Vaccines
    Influenza, Human
    Male
    Middle Aged
    Pneumonia, Viral
    Pulmonary Disease, Chronic Obstructive
    Republic of Korea
    Retrospective Studies

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23084847

    Citation

    Seo, Yu Bin, et al. "Effectiveness of the Influenza Vaccine at Preventing Hospitalization Due to Acute Lower Respiratory Infection and Exacerbation of Chronic Cardiopulmonary Disease in Korea During 2010-2011." Vaccine, vol. 31, no. 10, 2013, pp. 1426-30.
    Seo YB, Hong KW, Kim IS, et al. Effectiveness of the influenza vaccine at preventing hospitalization due to acute lower respiratory infection and exacerbation of chronic cardiopulmonary disease in Korea during 2010-2011. Vaccine. 2013;31(10):1426-30.
    Seo, Y. B., Hong, K. W., Kim, I. S., Choi, W. S., Baek, J. H., Lee, J., ... Kim, W. J. (2013). Effectiveness of the influenza vaccine at preventing hospitalization due to acute lower respiratory infection and exacerbation of chronic cardiopulmonary disease in Korea during 2010-2011. Vaccine, 31(10), pp. 1426-30. doi:10.1016/j.vaccine.2012.10.024.
    Seo YB, et al. Effectiveness of the Influenza Vaccine at Preventing Hospitalization Due to Acute Lower Respiratory Infection and Exacerbation of Chronic Cardiopulmonary Disease in Korea During 2010-2011. Vaccine. 2013 Feb 27;31(10):1426-30. PubMed PMID: 23084847.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effectiveness of the influenza vaccine at preventing hospitalization due to acute lower respiratory infection and exacerbation of chronic cardiopulmonary disease in Korea during 2010-2011. AU - Seo,Yu Bin, AU - Hong,Kyoung-wook, AU - Kim,In Seon, AU - Choi,Won Suk, AU - Baek,Ji Hyeon, AU - Lee,Jacob, AU - Song,Joon Young, AU - Lee,Jin Soo, AU - Cheong,Hee Jin, AU - Kim,Woo Joo, Y1 - 2012/10/19/ PY - 2012/06/01/received PY - 2012/08/31/revised PY - 2012/10/04/accepted PY - 2012/10/23/entrez PY - 2012/10/23/pubmed PY - 2013/8/13/medline SP - 1426 EP - 30 JF - Vaccine JO - Vaccine VL - 31 IS - 10 N2 - BACKGROUND: Influenza epidemics are accompanied by a considerable increase in hospitalization due to acute lower respiratory infection and exacerbation of underlying medical conditions. We estimated the effectiveness of the influenza vaccine at preventing hospitalization due to acute lower respiratory infection and new onset or acute exacerbation of chronic cardiopulmonary disease. METHOD: During the peak influenza period in 2010-2011, we performed a multicenter, case-control, retrospective cohort study of patients who were hospitalized due to newly developed pneumonia, bronchitis, and bronchiolitis, or new onset or acute exacerbation of asthma, COPD, ischemic heart disease, and CHF. Controls were selected from outpatients who visited study hospitals but who were not hospitalized during the same study period. Controls were matched 1:1 to cases based on age, gender, and date of hospital visit. Univariate and multivariate logistic regression analyses were used to determine the effectiveness of the influenza vaccine at decreasing hospitalization. RESULTS: Between December 2010 and February 2011, 556 hospitalized subjects were identified. Age, gender, and body mass index (BMI) were similar between case and control groups. The influenza vaccination rate of the hospitalized and non-hospitalized patients was 42.4% and 52.2%, respectively (p<0.001). The overall vaccine effectiveness for preventing hospitalization was 32.5% (odds ratio 0.675, 95% confidence interval [CI] 0.486-0.937; p=0.019). Multivariate logistic analysis showed that influenza vaccination significantly reduced the risk of hospitalization, especially due to new onset or acute exacerbation of ischemic heart disease and CHF in patients aged 65 years and older (OR 0.274, 95% CI 0.114-0.658, p=0.004). The estimated vaccine effectiveness in these patients was 72.6%. CONCLUSION: Influenza vaccination reduced the rate of hospitalization among patients with underlying chronic heart disease, particularly those patients 65 years old and greater. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/23084847/Effectiveness_of_the_influenza_vaccine_at_preventing_hospitalization_due_to_acute_lower_respiratory_infection_and_exacerbation_of_chronic_cardiopulmonary_disease_in_Korea_during_2010_2011_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(12)01470-3 DB - PRIME DP - Unbound Medicine ER -