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Adjunctive effects of aripiprazole on metabolic profiles: comparison of patients treated with olanzapine to patients treated with other atypical antipsychotic drugs.

Abstract

Metabolic abnormalities are serious adverse effects of atypical antipsychotic treatment. This study aims to determine the effects of adjunctive aripiprazole on metabolic profiles among patients receiving treatment with atypical antipsychotics, and to examine whether these effects are different from that of pre-existing atypical antipsychotics. In the 8-week open-label trial, aripiprazole was added to patients who were receiving treatment with atypical antipsychotics and had experienced weight gain or dyslipidemia. The dosage of pre-existing atypical antipsychotics was fixed, while the dosage of aripiprazole ranged from 5 to 20 mg/day during the study period. Metabolic profiles, including body weight, body mass index (BMI), plasma levels of fasting glucose, triglycerides, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and adiponectin, were measured at baseline and week 8. As a result, 43 subjects (16 males and 27 females, mean age: 37.8±10.8 years) completed the study. The pre-existing antipsychotics were olanzapine (n=12), risperidone (n=19), quetiapine (n=6) and amisulpiride (n=6). The mean dosage of adjunctive aripiprazole was 9.9±3.2 mg/day. After the aripiprazole-augmented regimen for 8 weeks, patients treated with olanzapine had significant decreases in body weight, BMI and triglyceride levels, and had significant increases in adiponectin levels. For patients treated with other atypical antipsychotics, none of the metabolic parameters significantly changed after administering aripiprazole. In conclusion, aripiprazole-augmented treatment might be beneficial for the metabolic regulation of patients being treated with a stable dose of olanzapine, but not for those treated with other atypical antipsychotics. A long-term, randomized, double-blind controlled design is suggested to confirm these findings.

Authors+Show Affiliations

Department of Psychiatry, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23085073

Citation

Wang, Liang-Jen, et al. "Adjunctive Effects of Aripiprazole On Metabolic Profiles: Comparison of Patients Treated With Olanzapine to Patients Treated With Other Atypical Antipsychotic Drugs." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 40, 2013, pp. 260-6.
Wang LJ, Ree SC, Huang YS, et al. Adjunctive effects of aripiprazole on metabolic profiles: comparison of patients treated with olanzapine to patients treated with other atypical antipsychotic drugs. Prog Neuropsychopharmacol Biol Psychiatry. 2013;40:260-6.
Wang, L. J., Ree, S. C., Huang, Y. S., Hsiao, C. C., & Chen, C. K. (2013). Adjunctive effects of aripiprazole on metabolic profiles: comparison of patients treated with olanzapine to patients treated with other atypical antipsychotic drugs. Progress in Neuro-psychopharmacology & Biological Psychiatry, 40, 260-6. https://doi.org/10.1016/j.pnpbp.2012.10.010
Wang LJ, et al. Adjunctive Effects of Aripiprazole On Metabolic Profiles: Comparison of Patients Treated With Olanzapine to Patients Treated With Other Atypical Antipsychotic Drugs. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:260-6. PubMed PMID: 23085073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adjunctive effects of aripiprazole on metabolic profiles: comparison of patients treated with olanzapine to patients treated with other atypical antipsychotic drugs. AU - Wang,Liang-Jen, AU - Ree,Shao-Chun, AU - Huang,Yu-Shu, AU - Hsiao,Cheng-Cheng, AU - Chen,Chih-Ken, Y1 - 2012/10/18/ PY - 2012/08/14/received PY - 2012/10/10/revised PY - 2012/10/11/accepted PY - 2012/10/23/entrez PY - 2012/10/23/pubmed PY - 2013/3/27/medline SP - 260 EP - 6 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 40 N2 - Metabolic abnormalities are serious adverse effects of atypical antipsychotic treatment. This study aims to determine the effects of adjunctive aripiprazole on metabolic profiles among patients receiving treatment with atypical antipsychotics, and to examine whether these effects are different from that of pre-existing atypical antipsychotics. In the 8-week open-label trial, aripiprazole was added to patients who were receiving treatment with atypical antipsychotics and had experienced weight gain or dyslipidemia. The dosage of pre-existing atypical antipsychotics was fixed, while the dosage of aripiprazole ranged from 5 to 20 mg/day during the study period. Metabolic profiles, including body weight, body mass index (BMI), plasma levels of fasting glucose, triglycerides, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and adiponectin, were measured at baseline and week 8. As a result, 43 subjects (16 males and 27 females, mean age: 37.8±10.8 years) completed the study. The pre-existing antipsychotics were olanzapine (n=12), risperidone (n=19), quetiapine (n=6) and amisulpiride (n=6). The mean dosage of adjunctive aripiprazole was 9.9±3.2 mg/day. After the aripiprazole-augmented regimen for 8 weeks, patients treated with olanzapine had significant decreases in body weight, BMI and triglyceride levels, and had significant increases in adiponectin levels. For patients treated with other atypical antipsychotics, none of the metabolic parameters significantly changed after administering aripiprazole. In conclusion, aripiprazole-augmented treatment might be beneficial for the metabolic regulation of patients being treated with a stable dose of olanzapine, but not for those treated with other atypical antipsychotics. A long-term, randomized, double-blind controlled design is suggested to confirm these findings. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/23085073/Adjunctive_effects_of_aripiprazole_on_metabolic_profiles:_comparison_of_patients_treated_with_olanzapine_to_patients_treated_with_other_atypical_antipsychotic_drugs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(12)00265-5 DB - PRIME DP - Unbound Medicine ER -