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Tetrandrine exerts antidepressant-like effects in animal models: role of brain-derived neurotrophic factor.
Behav Brain Res. 2013 Feb 01; 238:79-85.BB

Abstract

The present study focused on investigating the antidepressant potential of tetrandrine and its possible mechanisms of action. Forced swimming test (FST) and tail suspension test (TST) were used to reveal the antidepressant-like effect of tetrandrine. Potential mechanisms were explored applying reserpine-induced ptosis and hypothermia in mice, as well as using the chronic unpredictable mild stress (CUMS) induced depression model in rats. Tetrandrine reduced immobility time in both the FST and TST and antagonized reserpine-induced ptosis and hypothermia in mice. The concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in mice hippocampi decreased after the administration of reserpine. However, pre-treatments with tetrandrine significantly increased the concentrations of 5-HT and NE in mice hippocampi. In the CUMS-induced depressive rats, bodyweight, 1% sucrose consumption and the concentrations of 5-HT and NE in hippocampi decreased significantly compared with the normal control group. However, these changes could be significantly reversed by tetrandrine application. Furthermore, the levels of the brain-derived neurotrophic factor (BDNF) in hippocampi increased in the tetrandrine-treated rats exposed to CUMS. In summary, our findings suggest that the antidepressant-like effect of tetrandrine is involved in the regulation of the central monoaminergic neurotransmitter system and the levels of BDNF.

Authors+Show Affiliations

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23085478

Citation

Gao, Shan, et al. "Tetrandrine Exerts Antidepressant-like Effects in Animal Models: Role of Brain-derived Neurotrophic Factor." Behavioural Brain Research, vol. 238, 2013, pp. 79-85.
Gao S, Cui YL, Yu CQ, et al. Tetrandrine exerts antidepressant-like effects in animal models: role of brain-derived neurotrophic factor. Behav Brain Res. 2013;238:79-85.
Gao, S., Cui, Y. L., Yu, C. Q., Wang, Q. S., & Zhang, Y. (2013). Tetrandrine exerts antidepressant-like effects in animal models: role of brain-derived neurotrophic factor. Behavioural Brain Research, 238, 79-85. https://doi.org/10.1016/j.bbr.2012.10.015
Gao S, et al. Tetrandrine Exerts Antidepressant-like Effects in Animal Models: Role of Brain-derived Neurotrophic Factor. Behav Brain Res. 2013 Feb 1;238:79-85. PubMed PMID: 23085478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tetrandrine exerts antidepressant-like effects in animal models: role of brain-derived neurotrophic factor. AU - Gao,Shan, AU - Cui,Yuan-Lu, AU - Yu,Chun-Quan, AU - Wang,Qiang-Song, AU - Zhang,Ye, Y1 - 2012/10/22/ PY - 2012/03/03/received PY - 2012/10/07/revised PY - 2012/10/11/accepted PY - 2012/10/23/entrez PY - 2012/10/23/pubmed PY - 2013/5/18/medline SP - 79 EP - 85 JF - Behavioural brain research JO - Behav Brain Res VL - 238 N2 - The present study focused on investigating the antidepressant potential of tetrandrine and its possible mechanisms of action. Forced swimming test (FST) and tail suspension test (TST) were used to reveal the antidepressant-like effect of tetrandrine. Potential mechanisms were explored applying reserpine-induced ptosis and hypothermia in mice, as well as using the chronic unpredictable mild stress (CUMS) induced depression model in rats. Tetrandrine reduced immobility time in both the FST and TST and antagonized reserpine-induced ptosis and hypothermia in mice. The concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in mice hippocampi decreased after the administration of reserpine. However, pre-treatments with tetrandrine significantly increased the concentrations of 5-HT and NE in mice hippocampi. In the CUMS-induced depressive rats, bodyweight, 1% sucrose consumption and the concentrations of 5-HT and NE in hippocampi decreased significantly compared with the normal control group. However, these changes could be significantly reversed by tetrandrine application. Furthermore, the levels of the brain-derived neurotrophic factor (BDNF) in hippocampi increased in the tetrandrine-treated rats exposed to CUMS. In summary, our findings suggest that the antidepressant-like effect of tetrandrine is involved in the regulation of the central monoaminergic neurotransmitter system and the levels of BDNF. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/23085478/Tetrandrine_exerts_antidepressant_like_effects_in_animal_models:_role_of_brain_derived_neurotrophic_factor_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(12)00662-6 DB - PRIME DP - Unbound Medicine ER -