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The effect of smoking on the risk of gallbladder cancer: a meta-analysis of observational studies.
Eur J Gastroenterol Hepatol 2013; 25(3):373-9EJ

Abstract

BACKGROUND

Cigarette smoking has been shown to cause many nonpulmonary cancers, including those of liver, pancreas and bladder. However, results of epidemiologic studies examining the association between smoking and gallbladder cancer (GBC) have been mixed. To clarify the association of cigarette smoking and GBC, we performed a meta-analysis of observational studies.

METHODS

A literature search was performed using Medline (from 1 January 1966) and Embase (from 1 January 1974), through 31 January 2012, and by manually searching the reference lists of pertinent articles. Summary relative risks (SRRs) with corresponding 95% confidence intervals (CIs) were calculated with a random-effects model.

RESULTS

A total of 11 articles (10 case-control and one prospective cohort studies) were used in this meta-analysis, which is based on a total of 1178 GBC cases. Analysis of 11 studies found that smokers had an increased risk of GBC development, compared with nonsmokers (SRRs 1.45, 95% CIs, 1.11-1.89). There was moderate heterogeneity among studies (Q=18.15, P=0.052, I2 =44.9%). These increased risks were independent of alcohol use and a history of gallstones. No significant publication bias was found.

CONCLUSION

Although the current evidence supports a positive link between cigarette smoking and risk of gallbladder cancer, additional population-based studies, particularly cohort studies, are needed before definitive conclusions can be drawn.

Authors+Show Affiliations

Department of aInterventional Radiology, The First People's Hospital of Nantong, Jiangsu, China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

23085578

Citation

Wenbin, Ding, et al. "The Effect of Smoking On the Risk of Gallbladder Cancer: a Meta-analysis of Observational Studies." European Journal of Gastroenterology & Hepatology, vol. 25, no. 3, 2013, pp. 373-9.
Wenbin D, Zhuo C, Zhibing M, et al. The effect of smoking on the risk of gallbladder cancer: a meta-analysis of observational studies. Eur J Gastroenterol Hepatol. 2013;25(3):373-9.
Wenbin, D., Zhuo, C., Zhibing, M., Chen, Z., Ruifan, Y., Jie, J., ... Zhenming, G. (2013). The effect of smoking on the risk of gallbladder cancer: a meta-analysis of observational studies. European Journal of Gastroenterology & Hepatology, 25(3), pp. 373-9. doi:10.1097/MEG.0b013e32835a870b.
Wenbin D, et al. The Effect of Smoking On the Risk of Gallbladder Cancer: a Meta-analysis of Observational Studies. Eur J Gastroenterol Hepatol. 2013;25(3):373-9. PubMed PMID: 23085578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of smoking on the risk of gallbladder cancer: a meta-analysis of observational studies. AU - Wenbin,Ding, AU - Zhuo,Chen, AU - Zhibing,Ming, AU - Chen,Zhou, AU - Ruifan,Yuan, AU - Jie,Jin, AU - Cheng,Qian, AU - Zhenming,Ge, PY - 2012/10/23/entrez PY - 2012/10/23/pubmed PY - 2013/7/17/medline SP - 373 EP - 9 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 25 IS - 3 N2 - BACKGROUND: Cigarette smoking has been shown to cause many nonpulmonary cancers, including those of liver, pancreas and bladder. However, results of epidemiologic studies examining the association between smoking and gallbladder cancer (GBC) have been mixed. To clarify the association of cigarette smoking and GBC, we performed a meta-analysis of observational studies. METHODS: A literature search was performed using Medline (from 1 January 1966) and Embase (from 1 January 1974), through 31 January 2012, and by manually searching the reference lists of pertinent articles. Summary relative risks (SRRs) with corresponding 95% confidence intervals (CIs) were calculated with a random-effects model. RESULTS: A total of 11 articles (10 case-control and one prospective cohort studies) were used in this meta-analysis, which is based on a total of 1178 GBC cases. Analysis of 11 studies found that smokers had an increased risk of GBC development, compared with nonsmokers (SRRs 1.45, 95% CIs, 1.11-1.89). There was moderate heterogeneity among studies (Q=18.15, P=0.052, I2 =44.9%). These increased risks were independent of alcohol use and a history of gallstones. No significant publication bias was found. CONCLUSION: Although the current evidence supports a positive link between cigarette smoking and risk of gallbladder cancer, additional population-based studies, particularly cohort studies, are needed before definitive conclusions can be drawn. SN - 1473-5687 UR - https://www.unboundmedicine.com/medline/citation/23085578/The_effect_of_smoking_on_the_risk_of_gallbladder_cancer:_a_meta_analysis_of_observational_studies_ L2 - http://Insights.ovid.com/pubmed?pmid=23085578 DB - PRIME DP - Unbound Medicine ER -