Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation.ChemMedChem. 2012 Dec; 7(12):2134-43.C
Abstract
The introduction of a methylenthiol group at position 7 of camptothecin was carried out in four steps. This preparation also yielded the corresponding disulfide, which behaves as a prodrug due to its reactivity with glutathione. Assessment of their antiproliferative activities, investigations of their mechanism of action, and molecular modeling analysis indicated that the 7-modified camptothecin derivatives described herein maintain the biological activity and drug-target interactions of the parent compound.
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MeSH
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
23086693
Citation
Christodoulou, Michael S., et al. "Camptothecin-7-yl-methanthiole: Semisynthesis and Biological Evaluation." ChemMedChem, vol. 7, no. 12, 2012, pp. 2134-43.
Christodoulou MS, Zunino F, Zuco V, et al. Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation. ChemMedChem. 2012;7(12):2134-43.
Christodoulou, M. S., Zunino, F., Zuco, V., Borrelli, S., Comi, D., Fontana, G., Martinelli, M., Lorens, J. B., Evensen, L., Sironi, M., Pieraccini, S., Dalla Via, L., Gia, O. M., & Passarella, D. (2012). Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation. ChemMedChem, 7(12), 2134-43. https://doi.org/10.1002/cmdc.201200322
Christodoulou MS, et al. Camptothecin-7-yl-methanthiole: Semisynthesis and Biological Evaluation. ChemMedChem. 2012;7(12):2134-43. PubMed PMID: 23086693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation.
AU - Christodoulou,Michael S,
AU - Zunino,Franco,
AU - Zuco,Valentina,
AU - Borrelli,Stella,
AU - Comi,Daniela,
AU - Fontana,Gabriele,
AU - Martinelli,Marisa,
AU - Lorens,James B,
AU - Evensen,Lasse,
AU - Sironi,Maurizio,
AU - Pieraccini,Stefano,
AU - Dalla Via,Lisa,
AU - Gia,Ornella Maria,
AU - Passarella,Daniele,
Y1 - 2012/10/19/
PY - 2012/06/28/received
PY - 2012/09/13/revised
PY - 2012/10/23/entrez
PY - 2012/10/23/pubmed
PY - 2013/4/30/medline
SP - 2134
EP - 43
JF - ChemMedChem
JO - ChemMedChem
VL - 7
IS - 12
N2 - The introduction of a methylenthiol group at position 7 of camptothecin was carried out in four steps. This preparation also yielded the corresponding disulfide, which behaves as a prodrug due to its reactivity with glutathione. Assessment of their antiproliferative activities, investigations of their mechanism of action, and molecular modeling analysis indicated that the 7-modified camptothecin derivatives described herein maintain the biological activity and drug-target interactions of the parent compound.
SN - 1860-7187
UR - https://www.unboundmedicine.com/medline/citation/23086693/Camptothecin_7_yl_methanthiole:_semisynthesis_and_biological_evaluation_
L2 - https://doi.org/10.1002/cmdc.201200322
DB - PRIME
DP - Unbound Medicine
ER -