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N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads.
Br J Pharmacol. 2013 Jun; 169(4):772-83.BJ

Abstract

N-3 Long-chain polyunsaturated fatty acids (n-3 LC-PUFAs), in particular α-linolenic acid (18:3n-3), eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) are receiving much attention because of their presumed beneficial health effects. To explain these, a variety of mechanisms have been proposed, but their interactions with the endocannabinoid system have received relatively little attention so far. However, it has already been shown some time ago that consumption of n-3 LC-PUFAs not only affects the synthesis of prototypic endocannabinoids like anandamide but also stimulates the formation of specific n-3 LC-PUFA-derived conjugates with ethanolamine, dopamine, serotonin or other amines. Some of these fatty amides show overlapping biological activities with those of typical endocannabinoids, whereas others possess distinct and sometimes largely unknown receptor affinities and other properties. The ethanolamine and dopamine conjugates of DHA have been the most investigated thus far. These mediators may provide promising new leads to the field of inflammatory and neurological disorders and for other pharmacological applications, including their use as carrier molecules for neurotransmitters to target the brain. Furthermore, combinations of n-3 LC-PUFA-derived fatty acid amides, their precursors and FAAH inhibitors offer possibilities to optimise their effects in health and disease.

Authors+Show Affiliations

Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23088259

Citation

Meijerink, Jocelijn, et al. "N-Acyl Amines of Docosahexaenoic Acid and Other N-3 Polyunsatured Fatty Acids - From Fishy Endocannabinoids to Potential Leads." British Journal of Pharmacology, vol. 169, no. 4, 2013, pp. 772-83.
Meijerink J, Balvers M, Witkamp R. N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. Br J Pharmacol. 2013;169(4):772-83.
Meijerink, J., Balvers, M., & Witkamp, R. (2013). N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. British Journal of Pharmacology, 169(4), 772-83. https://doi.org/10.1111/bph.12030
Meijerink J, Balvers M, Witkamp R. N-Acyl Amines of Docosahexaenoic Acid and Other N-3 Polyunsatured Fatty Acids - From Fishy Endocannabinoids to Potential Leads. Br J Pharmacol. 2013;169(4):772-83. PubMed PMID: 23088259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. AU - Meijerink,Jocelijn, AU - Balvers,Michiel, AU - Witkamp,Renger, PY - 2012/06/21/received PY - 2012/09/15/revised PY - 2012/10/15/accepted PY - 2012/10/24/entrez PY - 2012/10/24/pubmed PY - 2014/10/9/medline SP - 772 EP - 83 JF - British journal of pharmacology JO - Br. J. Pharmacol. VL - 169 IS - 4 N2 - N-3 Long-chain polyunsaturated fatty acids (n-3 LC-PUFAs), in particular α-linolenic acid (18:3n-3), eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) are receiving much attention because of their presumed beneficial health effects. To explain these, a variety of mechanisms have been proposed, but their interactions with the endocannabinoid system have received relatively little attention so far. However, it has already been shown some time ago that consumption of n-3 LC-PUFAs not only affects the synthesis of prototypic endocannabinoids like anandamide but also stimulates the formation of specific n-3 LC-PUFA-derived conjugates with ethanolamine, dopamine, serotonin or other amines. Some of these fatty amides show overlapping biological activities with those of typical endocannabinoids, whereas others possess distinct and sometimes largely unknown receptor affinities and other properties. The ethanolamine and dopamine conjugates of DHA have been the most investigated thus far. These mediators may provide promising new leads to the field of inflammatory and neurological disorders and for other pharmacological applications, including their use as carrier molecules for neurotransmitters to target the brain. Furthermore, combinations of n-3 LC-PUFA-derived fatty acid amides, their precursors and FAAH inhibitors offer possibilities to optimise their effects in health and disease. SN - 1476-5381 UR - https://www.unboundmedicine.com/medline/citation/23088259/N_Acyl_amines_of_docosahexaenoic_acid_and_other_n_3_polyunsatured_fatty_acids___from_fishy_endocannabinoids_to_potential_leads_ L2 - https://doi.org/10.1111/bph.12030 DB - PRIME DP - Unbound Medicine ER -