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Four new sesquiterpenoids from Ligularia cymbulifera.
J Asian Nat Prod Res. 2012; 14(12):1130-6.JA

Abstract

Four new highly oxygenated bisabolane sesquiterpenoids were obtained from the EtOH extract from Ligularia cymbulifera, and their structures were elucidated by interpretation of spectroscopic data. Their relative configurations were clarified by a detailed analysis of ¹H NMR coupling constants, nuclear overhauser effect (NOE) experiments and two-dimensional NMR spectra. These four new compounds were assayed for their antimicrobial activities against four Gram-positive and Gram-negative bacteria, as well as against one human pathogenic fungus.

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Authors+Show Affiliations

Wu YX
School of Biotechnology and Chemical Engineering, Ningbo Institute of Technology, Zhejiang University, Ningbo 315100, China.
Chen YJ
No affiliation info available
Liu CM
No affiliation info available
Gao K
No affiliation info available

MeSH

AsteraceaeCandida albicansEnterobacter cloacaeEscherichia coliHumansMicrobial Sensitivity TestsMolecular StructureNuclear Magnetic Resonance, BiomolecularPseudomonas aeruginosaSesquiterpenesStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23088569

Citation

Wu, Yu-Xue, et al. "Four New Sesquiterpenoids From Ligularia Cymbulifera." Journal of Asian Natural Products Research, vol. 14, no. 12, 2012, pp. 1130-6.
Wu YX, Chen YJ, Liu CM, et al. Four new sesquiterpenoids from Ligularia cymbulifera. J Asian Nat Prod Res. 2012;14(12):1130-6.
Wu, Y. X., Chen, Y. J., Liu, C. M., & Gao, K. (2012). Four new sesquiterpenoids from Ligularia cymbulifera. Journal of Asian Natural Products Research, 14(12), 1130-6. https://doi.org/10.1080/10286020.2012.733002
Wu YX, et al. Four New Sesquiterpenoids From Ligularia Cymbulifera. J Asian Nat Prod Res. 2012;14(12):1130-6. PubMed PMID: 23088569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Four new sesquiterpenoids from Ligularia cymbulifera. AU - Wu,Yu-Xue, AU - Chen,Yan-Jun, AU - Liu,Chun-Mei, AU - Gao,Kun, Y1 - 2012/10/23/ PY - 2012/10/24/entrez PY - 2012/10/24/pubmed PY - 2013/2/14/medline SP - 1130 EP - 6 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 14 IS - 12 N2 - Four new highly oxygenated bisabolane sesquiterpenoids were obtained from the EtOH extract from Ligularia cymbulifera, and their structures were elucidated by interpretation of spectroscopic data. Their relative configurations were clarified by a detailed analysis of ¹H NMR coupling constants, nuclear overhauser effect (NOE) experiments and two-dimensional NMR spectra. These four new compounds were assayed for their antimicrobial activities against four Gram-positive and Gram-negative bacteria, as well as against one human pathogenic fungus. SN - 1477-2213 UR - https://www.unboundmedicine.com/medline/citation/23088569/Four_new_sesquiterpenoids_from_Ligularia_cymbulifera_ L2 - https://www.tandfonline.com/doi/full/10.1080/10286020.2012.733002 DB - PRIME DP - Unbound Medicine ER -