Tags

Type your tag names separated by a space and hit enter

Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis.
Dis Esophagus. 2014 Jul; 27(5):493-503.DE

Abstract

Although alcohol is associated with higher upper aerodigestive tract (UADT) cancer risk, only a small fraction of alcoholics develop cancers. There is a lack of evidence proving the association of tag single nucleotide polymorphisms of alcohol-metabolizing enzymes with cancer risk. The aim of this study was to determine the association of these genetic polymorphisms with UADT cancer risk in a Chinese population. It was a hospital-based case-control candidate gene study. The databases of the International HapMap Project were searched for haplotype tag single nucleotide polymorphisms of the genes alcohol dehydrogenase (ADH)1B, ADH1C, and aldehyde dehydrogenase (ALDH)2. The genotyping was performed by the Sequenom MassARRAY system. Totally, 120 head and neck squamous cell carcinoma, 138 esophageal squamous cell carcinoma patients, and 276 age- and gender-matched subjects were enrolled between June 2008 and June 2010.Minor alleles of ADH1B (rs1229984) and ALDH2(rs671) were not only associated with the risk of UADT cancers (odds ratio [OR] [95% confidence interval, CI]: 3.53 [2.14-5.80] and 2.59 [1.79-3.75], respectively) but also potentiated the carcinogenic effects of alcohol (OR [95% CI]: 53.44 [25.21-113.29] and 70.08 [33.65-145.95], respectively). Similar effects were observed for head/neck and esophageal cancer subgroups. Multivariate logistic regression analysis identified four significant risk factors, including habitual use of cigarettes, alcohol, betel quid, and lower body mass index (P < 0.001). The haplotypes GAGC (OR 1.61, 95% CI 1.08-2.40, P = 0.018) and CCAATG (OR 1.69, 95% CI 1.24-2.30, P < 0.001) on chromosomes 4 and 12, respectively, were associated with higher cancer risk. These findings suggested that risk allele or haplotype carriers who consume alcohol and other carcinogens should be advised to undergo endoscopy screening. The information can be used to determine the degree of susceptibility of each subject and can be combined with other environmental factors, like carcinogen consumption, in the screening analysis.

Authors+Show Affiliations

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23088731

Citation

Chung, C-S, et al. "Tag Single Nucleotide Polymorphisms of Alcohol-metabolizing Enzymes Modify the Risk of Upper Aerodigestive Tract Cancers: HapMap Database Analysis." Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus, vol. 27, no. 5, 2014, pp. 493-503.
Chung CS, Lee YC, Liou JM, et al. Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis. Dis Esophagus. 2014;27(5):493-503.
Chung, C. S., Lee, Y. C., Liou, J. M., Wang, C. P., Ko, J. Y., Lee, J. M., Wu, M. S., & Wang, H. P. (2014). Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis. Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus, 27(5), 493-503. https://doi.org/10.1111/j.1442-2050.2012.01437.x
Chung CS, et al. Tag Single Nucleotide Polymorphisms of Alcohol-metabolizing Enzymes Modify the Risk of Upper Aerodigestive Tract Cancers: HapMap Database Analysis. Dis Esophagus. 2014;27(5):493-503. PubMed PMID: 23088731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis. AU - Chung,C-S, AU - Lee,Y-C, AU - Liou,J-M, AU - Wang,C-P, AU - Ko,J-Y, AU - Lee,J-M, AU - Wu,M-S, AU - Wang,H-P, Y1 - 2012/10/22/ PY - 2012/10/24/entrez PY - 2012/10/24/pubmed PY - 2015/4/11/medline KW - alcohol-metabolizing enzyme KW - cancer risk KW - genetic polymorphism KW - tag single nucleotide polymorphism KW - upper aerodigestive tract cancer SP - 493 EP - 503 JF - Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus JO - Dis Esophagus VL - 27 IS - 5 N2 - Although alcohol is associated with higher upper aerodigestive tract (UADT) cancer risk, only a small fraction of alcoholics develop cancers. There is a lack of evidence proving the association of tag single nucleotide polymorphisms of alcohol-metabolizing enzymes with cancer risk. The aim of this study was to determine the association of these genetic polymorphisms with UADT cancer risk in a Chinese population. It was a hospital-based case-control candidate gene study. The databases of the International HapMap Project were searched for haplotype tag single nucleotide polymorphisms of the genes alcohol dehydrogenase (ADH)1B, ADH1C, and aldehyde dehydrogenase (ALDH)2. The genotyping was performed by the Sequenom MassARRAY system. Totally, 120 head and neck squamous cell carcinoma, 138 esophageal squamous cell carcinoma patients, and 276 age- and gender-matched subjects were enrolled between June 2008 and June 2010.Minor alleles of ADH1B (rs1229984) and ALDH2(rs671) were not only associated with the risk of UADT cancers (odds ratio [OR] [95% confidence interval, CI]: 3.53 [2.14-5.80] and 2.59 [1.79-3.75], respectively) but also potentiated the carcinogenic effects of alcohol (OR [95% CI]: 53.44 [25.21-113.29] and 70.08 [33.65-145.95], respectively). Similar effects were observed for head/neck and esophageal cancer subgroups. Multivariate logistic regression analysis identified four significant risk factors, including habitual use of cigarettes, alcohol, betel quid, and lower body mass index (P < 0.001). The haplotypes GAGC (OR 1.61, 95% CI 1.08-2.40, P = 0.018) and CCAATG (OR 1.69, 95% CI 1.24-2.30, P < 0.001) on chromosomes 4 and 12, respectively, were associated with higher cancer risk. These findings suggested that risk allele or haplotype carriers who consume alcohol and other carcinogens should be advised to undergo endoscopy screening. The information can be used to determine the degree of susceptibility of each subject and can be combined with other environmental factors, like carcinogen consumption, in the screening analysis. SN - 1442-2050 UR - https://www.unboundmedicine.com/medline/citation/23088731/Tag_single_nucleotide_polymorphisms_of_alcohol_metabolizing_enzymes_modify_the_risk_of_upper_aerodigestive_tract_cancers:_HapMap_database_analysis_ L2 - https://academic.oup.com/dote/article-lookup/doi/10.1111/j.1442-2050.2012.01437.x DB - PRIME DP - Unbound Medicine ER -