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Insight into newly discovered innate immune modulation in atopic dermatitis.
Exp Dermatol. 2013 Jan; 22(1):6-9.ED

Abstract

Atopic dermatitis (AD) is a highly pruritic, chronic relapsing inflammatory skin disease characterized by innate and adaptive immune reactions. In AD, innate immune mechanisms such as pattern recognition receptors and antimicrobial peptides have been investigated in detail, but recently, epidermis-derived cytokines, namely thymic stromal lymphopoietin (TSLP), IL-25 and IL-33, were shown to participate in innate immune reactions independently of adaptive immunity. In addition to conventional innate cells, such as mast cells, basophils and eosinophils, Th2 cytokine-producing invariant natural killer T (iNKT) cells, innate lymphoid cells (ILCs) and Th17/Th22 cytokine-producing innate cells - iNKT cells and natural killer (NK)-like cells - can participate in innate immune modulation in AD. Accordingly, early control of innate immune responses in AD before activation of adaptive immune responses by conventional T and B cells that perpetuate chronic skin inflammation may adequately alleviate acute exacerbations of AD. Therefore, we hypothesized that select immune modulators targeting the innate immune response could potentially be used for individualized treatment of AD.

Authors+Show Affiliations

Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23088736

Citation

Park, Chang Ook, et al. "Insight Into Newly Discovered Innate Immune Modulation in Atopic Dermatitis." Experimental Dermatology, vol. 22, no. 1, 2013, pp. 6-9.
Park CO, Noh S, Jin S, et al. Insight into newly discovered innate immune modulation in atopic dermatitis. Exp Dermatol. 2013;22(1):6-9.
Park, C. O., Noh, S., Jin, S., Lee, N. R., Lee, Y. S., Lee, H., Lee, J., & Lee, K. H. (2013). Insight into newly discovered innate immune modulation in atopic dermatitis. Experimental Dermatology, 22(1), 6-9. https://doi.org/10.1111/exd.12034
Park CO, et al. Insight Into Newly Discovered Innate Immune Modulation in Atopic Dermatitis. Exp Dermatol. 2013;22(1):6-9. PubMed PMID: 23088736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insight into newly discovered innate immune modulation in atopic dermatitis. AU - Park,Chang Ook, AU - Noh,Seongmin, AU - Jin,Shan, AU - Lee,Na Ra, AU - Lee,Yun Sun, AU - Lee,Hemin, AU - Lee,Jungsoo, AU - Lee,Kwang Hoon, Y1 - 2012/10/23/ PY - 2012/09/19/accepted PY - 2012/10/24/entrez PY - 2012/10/24/pubmed PY - 2013/6/29/medline SP - 6 EP - 9 JF - Experimental dermatology JO - Exp Dermatol VL - 22 IS - 1 N2 - Atopic dermatitis (AD) is a highly pruritic, chronic relapsing inflammatory skin disease characterized by innate and adaptive immune reactions. In AD, innate immune mechanisms such as pattern recognition receptors and antimicrobial peptides have been investigated in detail, but recently, epidermis-derived cytokines, namely thymic stromal lymphopoietin (TSLP), IL-25 and IL-33, were shown to participate in innate immune reactions independently of adaptive immunity. In addition to conventional innate cells, such as mast cells, basophils and eosinophils, Th2 cytokine-producing invariant natural killer T (iNKT) cells, innate lymphoid cells (ILCs) and Th17/Th22 cytokine-producing innate cells - iNKT cells and natural killer (NK)-like cells - can participate in innate immune modulation in AD. Accordingly, early control of innate immune responses in AD before activation of adaptive immune responses by conventional T and B cells that perpetuate chronic skin inflammation may adequately alleviate acute exacerbations of AD. Therefore, we hypothesized that select immune modulators targeting the innate immune response could potentially be used for individualized treatment of AD. SN - 1600-0625 UR - https://www.unboundmedicine.com/medline/citation/23088736/Insight_into_newly_discovered_innate_immune_modulation_in_atopic_dermatitis_ L2 - https://doi.org/10.1111/exd.12034 DB - PRIME DP - Unbound Medicine ER -