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Volumetric staging in oropharyngeal cancer patients treated with definitive IMRT.
Oral Oncol. 2013 Mar; 49(3):269-76.OO

Abstract

BACKGROUND

The superiority of volumetric staging (VS) over TNM/TNM-grouping system was previously prospectively tested in our head neck cancer population treated with intensity-modulated radiotherapy (IMRT); gross tumor volume (GTV) was the strongest predictor for disease control. Aim of this work was to specifically assess the prognostic value of VS in oropharyngeal cancer (OC).

PATIENTS

Between 04/2002 and 12/2011, 277 consecutive OC patients underwent definitive IMRT. Mean/median follow-up was 33/27 months (3-113). Three volumetric cut-offs were used (resulting in 4 GTV subgroups: 1-15 cc (14%), 16-70 cc (62%), 71-130 cc (20%), >130 cc (4%)).

METHODS

Outcome in the OC subgroup was prospectively assessed with VS and compared with that resulting from TNM and AJCC staging.

RESULTS

Primary GTV was most reliably predicting local control (p<0.0001), all other outcome parameters were predicted best by the total GTV (p<0.0001).

CONCLUSION

This is -to our knowledge- the first volumetric staging system for OC, and was found to be most reliable in predicting outcome in OC patients treated with IMRT.

Authors+Show Affiliations

Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland. gabriela.studer@usz.chNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23089460

Citation

Studer, Gabriela, and Christoph Glanzmann. "Volumetric Staging in Oropharyngeal Cancer Patients Treated With Definitive IMRT." Oral Oncology, vol. 49, no. 3, 2013, pp. 269-76.
Studer G, Glanzmann C. Volumetric staging in oropharyngeal cancer patients treated with definitive IMRT. Oral Oncol. 2013;49(3):269-76.
Studer, G., & Glanzmann, C. (2013). Volumetric staging in oropharyngeal cancer patients treated with definitive IMRT. Oral Oncology, 49(3), 269-76. https://doi.org/10.1016/j.oraloncology.2012.09.014
Studer G, Glanzmann C. Volumetric Staging in Oropharyngeal Cancer Patients Treated With Definitive IMRT. Oral Oncol. 2013;49(3):269-76. PubMed PMID: 23089460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Volumetric staging in oropharyngeal cancer patients treated with definitive IMRT. AU - Studer,Gabriela, AU - Glanzmann,Christoph, Y1 - 2012/10/22/ PY - 2012/08/15/received PY - 2012/09/22/revised PY - 2012/09/26/accepted PY - 2012/10/24/entrez PY - 2012/10/24/pubmed PY - 2013/8/24/medline SP - 269 EP - 76 JF - Oral oncology JO - Oral Oncol VL - 49 IS - 3 N2 - BACKGROUND: The superiority of volumetric staging (VS) over TNM/TNM-grouping system was previously prospectively tested in our head neck cancer population treated with intensity-modulated radiotherapy (IMRT); gross tumor volume (GTV) was the strongest predictor for disease control. Aim of this work was to specifically assess the prognostic value of VS in oropharyngeal cancer (OC). PATIENTS: Between 04/2002 and 12/2011, 277 consecutive OC patients underwent definitive IMRT. Mean/median follow-up was 33/27 months (3-113). Three volumetric cut-offs were used (resulting in 4 GTV subgroups: 1-15 cc (14%), 16-70 cc (62%), 71-130 cc (20%), >130 cc (4%)). METHODS: Outcome in the OC subgroup was prospectively assessed with VS and compared with that resulting from TNM and AJCC staging. RESULTS: Primary GTV was most reliably predicting local control (p<0.0001), all other outcome parameters were predicted best by the total GTV (p<0.0001). CONCLUSION: This is -to our knowledge- the first volumetric staging system for OC, and was found to be most reliable in predicting outcome in OC patients treated with IMRT. SN - 1879-0593 UR - https://www.unboundmedicine.com/medline/citation/23089460/Volumetric_staging_in_oropharyngeal_cancer_patients_treated_with_definitive_IMRT_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-8375(12)00317-X DB - PRIME DP - Unbound Medicine ER -