Tags

Type your tag names separated by a space and hit enter

The effect of long-term supplementation with branched-chain amino acid granules in patients with hepatitis C virus-related hepatocellular carcinoma after radiofrequency thermal ablation.
J Clin Gastroenterol 2013; 47(4):359-66JC

Abstract

GOALS

To elucidate whether long-term supplementation with branched-chain amino acid (BCAA) granules improves overall survival (OS) and recurrence-free survival (RFS) after radiofrequency thermal ablation (RFA) in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC)≤3 cm in diameter with up to 3 nodules and a serum albumin level before RFA of ≤3.5 g/dL.

BACKGROUND

Whether BCAA treatment after curative RFA for patients with HCV-related HCC improves OS and RFS remains unclear.

STUDY

We compared the OS rate and the RFS rate between the BCAA group (n=115) and the control group (n=141). We also examined factors contributing to OS and RFS.

RESULTS

The 1 and 3 years OS rates after RFA were 94.0% and 70.0%, respectively, in the BCAA group, and 94.0% and 49.8%, respectively, in the control group (P=0.001). The corresponding RFS rates 1 and 3 years after RFA were 61.8% and 28.0%, respectively, in the BCAA group, and 52.0% and 12.0%, respectively, in the control group (P=0.013). In the multivariate analysis, in terms of OS, BCAA treatment, and serum albumin level of ≥3.4 g/dL, and in terms of RFS, age 70 years or older, BCAA treatment, and a serum albumin level of ≥3.4 g/dL were significant independent factors, respectively.

CONCLUSIONS

BCAA treatment may improve OS and RFS after RFA in patients with HCV-related HCC≤3 cm in diameter with up to 3 nodules and a serum albumin level before RFA of 3.5 g/dL.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Tennoji-ku, Osaka, Japan. h-nishikawa@osaka-med.jrc.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23090049

Citation

Nishikawa, Hiroki, et al. "The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation." Journal of Clinical Gastroenterology, vol. 47, no. 4, 2013, pp. 359-66.
Nishikawa H, Osaki Y, Iguchi E, et al. The effect of long-term supplementation with branched-chain amino acid granules in patients with hepatitis C virus-related hepatocellular carcinoma after radiofrequency thermal ablation. J Clin Gastroenterol. 2013;47(4):359-66.
Nishikawa, H., Osaki, Y., Iguchi, E., Koshikawa, Y., Ako, S., Inuzuka, T., ... Kimura, T. (2013). The effect of long-term supplementation with branched-chain amino acid granules in patients with hepatitis C virus-related hepatocellular carcinoma after radiofrequency thermal ablation. Journal of Clinical Gastroenterology, 47(4), pp. 359-66. doi:10.1097/MCG.0b013e31826be9ad.
Nishikawa H, et al. The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation. J Clin Gastroenterol. 2013;47(4):359-66. PubMed PMID: 23090049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of long-term supplementation with branched-chain amino acid granules in patients with hepatitis C virus-related hepatocellular carcinoma after radiofrequency thermal ablation. AU - Nishikawa,Hiroki, AU - Osaki,Yukio, AU - Iguchi,Eriko, AU - Koshikawa,Yorimitsu, AU - Ako,Soichiro, AU - Inuzuka,Tadashi, AU - Takeda,Haruhiko, AU - Nakajima,Jun, AU - Matsuda,Fumihiro, AU - Sakamoto,Azusa, AU - Henmi,Shinichiro, AU - Hatamaru,Keiichi, AU - Ishikawa,Tetsuro, AU - Saito,Sumio, AU - Nasu,Akihiro, AU - Kita,Ryuichi, AU - Kimura,Toru, PY - 2012/10/24/entrez PY - 2012/10/24/pubmed PY - 2013/8/27/medline SP - 359 EP - 66 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 47 IS - 4 N2 - GOALS: To elucidate whether long-term supplementation with branched-chain amino acid (BCAA) granules improves overall survival (OS) and recurrence-free survival (RFS) after radiofrequency thermal ablation (RFA) in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC)≤3 cm in diameter with up to 3 nodules and a serum albumin level before RFA of ≤3.5 g/dL. BACKGROUND: Whether BCAA treatment after curative RFA for patients with HCV-related HCC improves OS and RFS remains unclear. STUDY: We compared the OS rate and the RFS rate between the BCAA group (n=115) and the control group (n=141). We also examined factors contributing to OS and RFS. RESULTS: The 1 and 3 years OS rates after RFA were 94.0% and 70.0%, respectively, in the BCAA group, and 94.0% and 49.8%, respectively, in the control group (P=0.001). The corresponding RFS rates 1 and 3 years after RFA were 61.8% and 28.0%, respectively, in the BCAA group, and 52.0% and 12.0%, respectively, in the control group (P=0.013). In the multivariate analysis, in terms of OS, BCAA treatment, and serum albumin level of ≥3.4 g/dL, and in terms of RFS, age 70 years or older, BCAA treatment, and a serum albumin level of ≥3.4 g/dL were significant independent factors, respectively. CONCLUSIONS: BCAA treatment may improve OS and RFS after RFA in patients with HCV-related HCC≤3 cm in diameter with up to 3 nodules and a serum albumin level before RFA of 3.5 g/dL. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/23090049/The_effect_of_long_term_supplementation_with_branched_chain_amino_acid_granules_in_patients_with_hepatitis_C_virus_related_hepatocellular_carcinoma_after_radiofrequency_thermal_ablation_ L2 - http://dx.doi.org/10.1097/MCG.0b013e31826be9ad DB - PRIME DP - Unbound Medicine ER -