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Height, age at menarche and risk of hormone receptor-positive and -negative breast cancer: a cohort study.

Abstract

Associations of breast cancer overall with indicators of exposures during puberty are reasonably well characterized; however, uncertainty remains regarding the associations of height, leg length, sitting height and menarcheal age with hormone receptor-defined malignancies. Within the European Prospective Investigation into Cancer and Nutrition cohort, Cox proportional hazards models were used to describe the relationships of adult height, leg length and sitting height and age at menarche with risk of estrogen and progesterone receptor negative (ER-PR-) (n = 990) and ER+PR+ (n = 3,524) breast tumors. Height as a single risk factor was compared to a model combining leg length and sitting height. The possible interactions of height, leg length and sitting height with menarche were also analyzed. Risk of both ER-PR- and ER+PR+ malignancies was positively associated with standing height, leg length and sitting height and inversely associated with increasing age at menarche. For ER+PR+ disease, sitting height (hazard ratios: 1.14[95% confidence interval: 1.08-1.20]) had a stronger risk association than leg length (1.05[1.00-1.11]). In comparison, for ER-PR- disease, no distinct differences were observed between leg length and sitting height. Women who were tall and had an early menarche (≤13 years) showed an almost twofold increase in risk of ER+PR+ tumors but no such increase in risk was observed for ER-PR- disease. Indicators of exposures during rapid growth periods were associated with risks of both HR-defined breast cancers. Exposures during childhood promoting faster development may establish risk associations for both HR-positive and -negative malignancies. The stronger associations of the components of height with ER+PR+ tumors among older women suggest possible hormonal links that could be specific for postmenopausal women.

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  • Authors+Show Affiliations

    ,

    Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

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    Source

    International journal of cancer 132:11 2013 Jun 01 pg 2619-29

    MeSH

    Adult
    Age Factors
    Biomarkers, Tumor
    Body Height
    Breast Neoplasms
    Estrogens
    Europe
    Female
    Follow-Up Studies
    Humans
    Leg
    Menarche
    Middle Aged
    Prognosis
    Prospective Studies
    Receptors, Estrogen
    Receptors, Progesterone
    Risk Factors

    Pub Type(s)

    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    23090881

    Citation

    Ritte, Rebecca, et al. "Height, Age at Menarche and Risk of Hormone Receptor-positive and -negative Breast Cancer: a Cohort Study." International Journal of Cancer, vol. 132, no. 11, 2013, pp. 2619-29.
    Ritte R, Lukanova A, Tjønneland A, et al. Height, age at menarche and risk of hormone receptor-positive and -negative breast cancer: a cohort study. Int J Cancer. 2013;132(11):2619-29.
    Ritte, R., Lukanova, A., Tjønneland, A., Olsen, A., Overvad, K., Mesrine, S., ... Kaaks, R. (2013). Height, age at menarche and risk of hormone receptor-positive and -negative breast cancer: a cohort study. International Journal of Cancer, 132(11), pp. 2619-29. doi:10.1002/ijc.27913.
    Ritte R, et al. Height, Age at Menarche and Risk of Hormone Receptor-positive and -negative Breast Cancer: a Cohort Study. Int J Cancer. 2013 Jun 1;132(11):2619-29. PubMed PMID: 23090881.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Height, age at menarche and risk of hormone receptor-positive and -negative breast cancer: a cohort study. AU - Ritte,Rebecca, AU - Lukanova,Annekatrin, AU - Tjønneland,Anne, AU - Olsen,Anja, AU - Overvad,Kim, AU - Mesrine,Sylvie, AU - Fagherazzi,Guy, AU - Dossus,Laure, AU - Teucher,Birgit, AU - Steindorf,Karen, AU - Boeing,Heiner, AU - Aleksandrova,Krasimira, AU - Trichopoulou,Antonia, AU - Lagiou,Pagona, AU - Trichopoulos,Dimitrios, AU - Palli,Domenico, AU - Grioni,Sara, AU - Mattiello,Amalia, AU - Tumino,Rosario, AU - Sacerdote,Carlotta, AU - Quirós,José Ramón, AU - Buckland,Genevieve, AU - Molina-Montes,Esther, AU - Chirlaque,María-Dolores, AU - Ardanaz,Eva, AU - Amiano,Pilar, AU - Bueno-de-Mesquita,Bas, AU - van Duijnhoven,Franzel, AU - van Gils,Carla H, AU - Peeters,Petra Hm, AU - Wareham,Nick, AU - Khaw,Kay-Tee, AU - Key,Timothy J, AU - Travis,Ruth C, AU - Krum-Hansen,Sanda, AU - Gram,Inger Torhild, AU - Lund,Eiliv, AU - Sund,Malin, AU - Andersson,Anne, AU - Romieu,Isabelle, AU - Rinaldi,Sabina, AU - McCormack,Valerie, AU - Riboli,Elio, AU - Kaaks,Rudolf, Y1 - 2012/11/14/ PY - 2012/03/28/received PY - 2012/09/17/accepted PY - 2012/10/24/entrez PY - 2012/10/24/pubmed PY - 2013/5/29/medline SP - 2619 EP - 29 JF - International journal of cancer JO - Int. J. Cancer VL - 132 IS - 11 N2 - Associations of breast cancer overall with indicators of exposures during puberty are reasonably well characterized; however, uncertainty remains regarding the associations of height, leg length, sitting height and menarcheal age with hormone receptor-defined malignancies. Within the European Prospective Investigation into Cancer and Nutrition cohort, Cox proportional hazards models were used to describe the relationships of adult height, leg length and sitting height and age at menarche with risk of estrogen and progesterone receptor negative (ER-PR-) (n = 990) and ER+PR+ (n = 3,524) breast tumors. Height as a single risk factor was compared to a model combining leg length and sitting height. The possible interactions of height, leg length and sitting height with menarche were also analyzed. Risk of both ER-PR- and ER+PR+ malignancies was positively associated with standing height, leg length and sitting height and inversely associated with increasing age at menarche. For ER+PR+ disease, sitting height (hazard ratios: 1.14[95% confidence interval: 1.08-1.20]) had a stronger risk association than leg length (1.05[1.00-1.11]). In comparison, for ER-PR- disease, no distinct differences were observed between leg length and sitting height. Women who were tall and had an early menarche (≤13 years) showed an almost twofold increase in risk of ER+PR+ tumors but no such increase in risk was observed for ER-PR- disease. Indicators of exposures during rapid growth periods were associated with risks of both HR-defined breast cancers. Exposures during childhood promoting faster development may establish risk associations for both HR-positive and -negative malignancies. The stronger associations of the components of height with ER+PR+ tumors among older women suggest possible hormonal links that could be specific for postmenopausal women. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/23090881/Height_age_at_menarche_and_risk_of_hormone_receptor_positive_and__negative_breast_cancer:_a_cohort_study_ L2 - https://doi.org/10.1002/ijc.27913 DB - PRIME DP - Unbound Medicine ER -