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Alcohol consumption and mortality in the Korean Multi-Center Cancer Cohort Study.
J Prev Med Public Health. 2012 Sep; 45(5):301-8.JP

Abstract

OBJECTIVES

To examine the association between alcohol consumption habit, types of beverages, alcohol consumption quantity, and overall and cancer-specific mortality among Korean adults.

METHODS

The alcohol consumption information of a total of 16 320 participants who were 20 years or older from the Korean Multi-center Cancer Cohort were analyzed to examine the association between alcohol consumption habit and mortality (median follow-up of 9.3 years). The Cox proportional hazard model was used to estimate the hazard ratio (HR) of alcohol consumption to mortality adjusting for age, sex, geographic areas, education, smoking status, and body mass index.

RESULTS

Alcohol drinkers showed an increased risk for total mortality compared with never drinkers (HR, 1.72; 95% confidence interval [CI], 1.38 to 2.14 for past drinkers; HR, 1.21; 95% CI, 1.06 to 1.39 for current drinkers), while past drinkers only were associated with higher risk for cancer deaths (HR, 1.84; 95% CI, 1.34 to 2.53). The quantity of alcohol consumed per week showed a J-shaped association with risk of mortality. Relative to light drinkers (0.01 to 90 g/wk), never drinkers and heavy drinkers (>504 g/wk) had an increased risk for all-cause and cancer deaths: (HR, 1.18; 95% CI, 0.96 to 1.45) and (HR, 1.39; 95% CI, 1.05 to 1.83) for all-cause mortality; and (HR, 1.55; 95% CI, 1.15 to 2.11) and (HR, 2.07; 95% CI, 1.39 to 3.09) for all cancer mortality, respectively. Heavy drinkers (>504 g/wk) showed an elevated risk for death from stomach and liver cancers.

CONCLUSIONS

The present study supports the existence of a J-shaped association between alcohol consumption quantity and the risk of all-cause and cancer deaths. Heavy drinkers had an increased risk of death from cancer overall and liver and stomach cancer.

Authors+Show Affiliations

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

23091655

Citation

Jung, En-Joo, et al. "Alcohol Consumption and Mortality in the Korean Multi-Center Cancer Cohort Study." Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, vol. 45, no. 5, 2012, pp. 301-8.
Jung EJ, Shin A, Park SK, et al. Alcohol consumption and mortality in the Korean Multi-Center Cancer Cohort Study. J Prev Med Public Health. 2012;45(5):301-8.
Jung, E. J., Shin, A., Park, S. K., Ma, S. H., Cho, I. S., Park, B., Lee, E. H., Chang, S. H., Shin, H. R., Kang, D., & Yoo, K. Y. (2012). Alcohol consumption and mortality in the Korean Multi-Center Cancer Cohort Study. Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, 45(5), 301-8. https://doi.org/10.3961/jpmph.2012.45.5.301
Jung EJ, et al. Alcohol Consumption and Mortality in the Korean Multi-Center Cancer Cohort Study. J Prev Med Public Health. 2012;45(5):301-8. PubMed PMID: 23091655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and mortality in the Korean Multi-Center Cancer Cohort Study. AU - Jung,En-Joo, AU - Shin,Aesun, AU - Park,Sue K, AU - Ma,Seung-Hyun, AU - Cho,In-Seong, AU - Park,Boyoung, AU - Lee,Eun-Ha, AU - Chang,Soung-Hoon, AU - Shin,Hai-Rim, AU - Kang,Daehee, AU - Yoo,Keun-Young, Y1 - 2012/09/28/ PY - 2012/03/12/received PY - 2012/06/25/accepted PY - 2012/10/24/entrez PY - 2012/10/24/pubmed PY - 2013/12/16/medline KW - Alcohol drinking KW - Korea KW - Korean Multi-center Cancer Cohort KW - Mortality SP - 301 EP - 8 JF - Journal of preventive medicine and public health = Yebang Uihakhoe chi JO - J Prev Med Public Health VL - 45 IS - 5 N2 - OBJECTIVES: To examine the association between alcohol consumption habit, types of beverages, alcohol consumption quantity, and overall and cancer-specific mortality among Korean adults. METHODS: The alcohol consumption information of a total of 16 320 participants who were 20 years or older from the Korean Multi-center Cancer Cohort were analyzed to examine the association between alcohol consumption habit and mortality (median follow-up of 9.3 years). The Cox proportional hazard model was used to estimate the hazard ratio (HR) of alcohol consumption to mortality adjusting for age, sex, geographic areas, education, smoking status, and body mass index. RESULTS: Alcohol drinkers showed an increased risk for total mortality compared with never drinkers (HR, 1.72; 95% confidence interval [CI], 1.38 to 2.14 for past drinkers; HR, 1.21; 95% CI, 1.06 to 1.39 for current drinkers), while past drinkers only were associated with higher risk for cancer deaths (HR, 1.84; 95% CI, 1.34 to 2.53). The quantity of alcohol consumed per week showed a J-shaped association with risk of mortality. Relative to light drinkers (0.01 to 90 g/wk), never drinkers and heavy drinkers (>504 g/wk) had an increased risk for all-cause and cancer deaths: (HR, 1.18; 95% CI, 0.96 to 1.45) and (HR, 1.39; 95% CI, 1.05 to 1.83) for all-cause mortality; and (HR, 1.55; 95% CI, 1.15 to 2.11) and (HR, 2.07; 95% CI, 1.39 to 3.09) for all cancer mortality, respectively. Heavy drinkers (>504 g/wk) showed an elevated risk for death from stomach and liver cancers. CONCLUSIONS: The present study supports the existence of a J-shaped association between alcohol consumption quantity and the risk of all-cause and cancer deaths. Heavy drinkers had an increased risk of death from cancer overall and liver and stomach cancer. SN - 2233-4521 UR - https://www.unboundmedicine.com/medline/citation/23091655/Alcohol_consumption_and_mortality_in_the_Korean_Multi_Center_Cancer_Cohort_Study_ L2 - https://dx.doi.org/10.3961/jpmph.2012.45.5.301 DB - PRIME DP - Unbound Medicine ER -