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Therapeutic effects of vitamin D as adjunctive therapy to fluoxetine in patients with major depressive disorder.
Aust N Z J Psychiatry. 2013 Mar; 47(3):271-5.AN

Abstract

OBJECTIVE

To compare the therapeutic effects of vitamin D3 plus fluoxetine and fluoxetine alone in patients with major depressive disorder.

METHODS

In the present double-blind, randomized, placebo-controlled trial, 42 patients with a diagnosis of major depressive disorder based on DSM-IV criteria were randomly assigned into two groups to receive daily either 1500 IU vitamin D3 plus 20 mg fluoxetine or fluoxetine alone for 8 weeks. Depression severity was assessed at 2-week intervals using the 24-item Hamilton Depression Rating Scale (HDRS) as a primary outcome measure and the 21-item Beck Depression Inventory (BDI) as a secondary outcome measure. Serum 25(OH) vitamin D was measured at baseline and after intervention.

RESULTS

Forty patients completed the trial. A two-way repeated-measures analysis of variance showed that depression severity based on HDRS and BDI decreased significantly after intervention, with a significant difference between the two groups. The vitamin D + fluoxetine combination was significantly better than fluoxetine alone from the fourth week of treatment.

CONCLUSIONS

In the present 8-week trial, the vitamin D + fluoxetine combination was superior to fluoxetine alone in controlling depressive symptoms.

Authors+Show Affiliations

Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23093054

Citation

Khoraminya, Nayereh, et al. "Therapeutic Effects of Vitamin D as Adjunctive Therapy to Fluoxetine in Patients With Major Depressive Disorder." The Australian and New Zealand Journal of Psychiatry, vol. 47, no. 3, 2013, pp. 271-5.
Khoraminya N, Tehrani-Doost M, Jazayeri S, et al. Therapeutic effects of vitamin D as adjunctive therapy to fluoxetine in patients with major depressive disorder. Aust N Z J Psychiatry. 2013;47(3):271-5.
Khoraminya, N., Tehrani-Doost, M., Jazayeri, S., Hosseini, A., & Djazayery, A. (2013). Therapeutic effects of vitamin D as adjunctive therapy to fluoxetine in patients with major depressive disorder. The Australian and New Zealand Journal of Psychiatry, 47(3), 271-5. https://doi.org/10.1177/0004867412465022
Khoraminya N, et al. Therapeutic Effects of Vitamin D as Adjunctive Therapy to Fluoxetine in Patients With Major Depressive Disorder. Aust N Z J Psychiatry. 2013;47(3):271-5. PubMed PMID: 23093054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic effects of vitamin D as adjunctive therapy to fluoxetine in patients with major depressive disorder. AU - Khoraminya,Nayereh, AU - Tehrani-Doost,Mehdi, AU - Jazayeri,Shima, AU - Hosseini,Aghafateme, AU - Djazayery,Abolghassem, Y1 - 2012/10/23/ PY - 2012/10/25/entrez PY - 2012/10/25/pubmed PY - 2014/1/17/medline SP - 271 EP - 5 JF - The Australian and New Zealand journal of psychiatry JO - Aust N Z J Psychiatry VL - 47 IS - 3 N2 - OBJECTIVE: To compare the therapeutic effects of vitamin D3 plus fluoxetine and fluoxetine alone in patients with major depressive disorder. METHODS: In the present double-blind, randomized, placebo-controlled trial, 42 patients with a diagnosis of major depressive disorder based on DSM-IV criteria were randomly assigned into two groups to receive daily either 1500 IU vitamin D3 plus 20 mg fluoxetine or fluoxetine alone for 8 weeks. Depression severity was assessed at 2-week intervals using the 24-item Hamilton Depression Rating Scale (HDRS) as a primary outcome measure and the 21-item Beck Depression Inventory (BDI) as a secondary outcome measure. Serum 25(OH) vitamin D was measured at baseline and after intervention. RESULTS: Forty patients completed the trial. A two-way repeated-measures analysis of variance showed that depression severity based on HDRS and BDI decreased significantly after intervention, with a significant difference between the two groups. The vitamin D + fluoxetine combination was significantly better than fluoxetine alone from the fourth week of treatment. CONCLUSIONS: In the present 8-week trial, the vitamin D + fluoxetine combination was superior to fluoxetine alone in controlling depressive symptoms. SN - 1440-1614 UR - https://www.unboundmedicine.com/medline/citation/23093054/Therapeutic_effects_of_vitamin_D_as_adjunctive_therapy_to_fluoxetine_in_patients_with_major_depressive_disorder_ L2 - http://journals.sagepub.com/doi/full/10.1177/0004867412465022?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -