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Proteomic biomarkers of type 2 diabetes mellitus risk in women with polycystic ovary syndrome.
Eur J Endocrinol 2013; 168(2):R33-43EJ

Abstract

Women with polycystic ovary syndrome (PCOS) are at increased risk of developing insulin resistance and type 2 diabetes mellitus (T2DM). In this study, we attempted to list the proteomic biomarkers of PCOS and T2DM that have been published in the literature so far. We identified eight common biomarkers that were differentially expressed in both women with PCOS and T2DM when compared with healthy controls. These include pyruvate kinase M1/M2, apolipoprotein A-I, albumin, peroxiredoxin 2, annexin A2, α-1-B-glycoprotein, flotillin-1 and haptoglobin. These biomarkers could help improve our understanding of the links between PCOS and T2DM and could be potentially used to identify subgroups of women with PCOS at increased risk of T2DM. More studies are required to further evaluate the role these biomarkers play in women with PCOS and T2DM.

Authors+Show Affiliations

Division of Human Development, School of Clinical Sciences, Nottingham University Hospitals, University of Nottingham D Floor, East Block, Queens Medical Centre Campus, Nottingham NG7 2UH, UK. ngalazis@gmail.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23093701

Citation

Galazis, Nicolas, et al. "Proteomic Biomarkers of Type 2 Diabetes Mellitus Risk in Women With Polycystic Ovary Syndrome." European Journal of Endocrinology, vol. 168, no. 2, 2013, pp. R33-43.
Galazis N, Afxentiou T, Xenophontos M, et al. Proteomic biomarkers of type 2 diabetes mellitus risk in women with polycystic ovary syndrome. Eur J Endocrinol. 2013;168(2):R33-43.
Galazis, N., Afxentiou, T., Xenophontos, M., Diamanti-Kandarakis, E., & Atiomo, W. (2013). Proteomic biomarkers of type 2 diabetes mellitus risk in women with polycystic ovary syndrome. European Journal of Endocrinology, 168(2), pp. R33-43. doi:10.1530/EJE-12-0718.
Galazis N, et al. Proteomic Biomarkers of Type 2 Diabetes Mellitus Risk in Women With Polycystic Ovary Syndrome. Eur J Endocrinol. 2013;168(2):R33-43. PubMed PMID: 23093701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Proteomic biomarkers of type 2 diabetes mellitus risk in women with polycystic ovary syndrome. AU - Galazis,Nicolas, AU - Afxentiou,Thalia, AU - Xenophontos,Mikalena, AU - Diamanti-Kandarakis,Evanthia, AU - Atiomo,William, Y1 - 2013/02/01/ PY - 2012/10/25/entrez PY - 2012/10/25/pubmed PY - 2013/3/6/medline SP - R33 EP - 43 JF - European journal of endocrinology JO - Eur. J. Endocrinol. VL - 168 IS - 2 N2 - Women with polycystic ovary syndrome (PCOS) are at increased risk of developing insulin resistance and type 2 diabetes mellitus (T2DM). In this study, we attempted to list the proteomic biomarkers of PCOS and T2DM that have been published in the literature so far. We identified eight common biomarkers that were differentially expressed in both women with PCOS and T2DM when compared with healthy controls. These include pyruvate kinase M1/M2, apolipoprotein A-I, albumin, peroxiredoxin 2, annexin A2, α-1-B-glycoprotein, flotillin-1 and haptoglobin. These biomarkers could help improve our understanding of the links between PCOS and T2DM and could be potentially used to identify subgroups of women with PCOS at increased risk of T2DM. More studies are required to further evaluate the role these biomarkers play in women with PCOS and T2DM. SN - 1479-683X UR - https://www.unboundmedicine.com/medline/citation/23093701/Proteomic_biomarkers_of_type_2_diabetes_mellitus_risk_in_women_with_polycystic_ovary_syndrome_ L2 - https://eje.bioscientifica.com/doi/10.1530/EJE-12-0718 DB - PRIME DP - Unbound Medicine ER -