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Multiparametric statistical correlations between paranasal sinus anatomic variations and chronic rhinosinusitis.
Acta Otorhinolaryngol Ital. 2012 Aug; 32(4):244-51.AO

Abstract

Improvements in functional endoscopic sinus surgery (FESS) and computed tomography (CT) have concurrently increased interest in the anatomy of the paranasal region. Common anatomical variations are not rare in patients with chronic paranasal sinusitis. The aim of this retrospective study was to analyze the incidence of anatomic variations of the lateral nasal wall in a series of 200 patients with persistent symptoms of rhinosinusitis, after failure of medical therapies, and their correlation with paranasal sinus disease. A detailed analysis of CT scans showed that 140 of 200 (70%) patients had anatomic variations. In particular, 122 patients (87%) were affected by common anatomic variations, and 18 patients (13%) with uncommon variations. There were 85 (60.7%) male and 55 (39.3%) females with ages ranging from 13 to 77 years (mean 45.5 years). The maxillary sinus was most commonly involved, followed by the anterior ethmoid, frontal sinus, posterior ethmoid and sphenoid sinus. Statistically significant association was found between the presence of common anatomic variations - septal deviation, bilateral concha bullosa, medial deviation of uncinate process, Haller cell, ethmoidal bulla hypertrophic, agger nasi cell - and the presence of sinus mucosal disease (p < 0.05). There was no significant correlation between other common and uncommon anatomic variations and mucosal pathologies. The associations were evaluated using the Fisher's exact test, and compared with those reported in the literature. Considering the results obtained, we believe that some anatomic variations may increase the risk of sinus mucosal disease. We therefore emphasize the importance of a careful evaluation of CT study in patients with persistent symptoms and recurrent chronic rhinosinusitis in order to identify those with anatomical variations that may have an increased risk of developing rhinosinusitis.

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Authors+Show Affiliations

Fadda GL
ENT DEPT San Luigi Gonzaga, University Hospital, Turin, Italy. gl.fadda@libero.it
Rosso S
No affiliation info available
Aversa S
No affiliation info available
Petrelli A
No affiliation info available
Ondolo C
No affiliation info available
Succo G
No affiliation info available

MeSH

AdolescentAdultAgedChronic DiseaseFemaleHumansMaleMiddle AgedParanasal SinusesRetrospective StudiesRhinitisSinusitisStatistics as TopicYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23093814

Citation

Fadda, G L., et al. "Multiparametric Statistical Correlations Between Paranasal Sinus Anatomic Variations and Chronic Rhinosinusitis." Acta Otorhinolaryngologica Italica : Organo Ufficiale Della Societa Italiana Di Otorinolaringologia E Chirurgia Cervico-facciale, vol. 32, no. 4, 2012, pp. 244-51.
Fadda GL, Rosso S, Aversa S, et al. Multiparametric statistical correlations between paranasal sinus anatomic variations and chronic rhinosinusitis. Acta Otorhinolaryngol Ital. 2012;32(4):244-51.
Fadda, G. L., Rosso, S., Aversa, S., Petrelli, A., Ondolo, C., & Succo, G. (2012). Multiparametric statistical correlations between paranasal sinus anatomic variations and chronic rhinosinusitis. Acta Otorhinolaryngologica Italica : Organo Ufficiale Della Societa Italiana Di Otorinolaringologia E Chirurgia Cervico-facciale, 32(4), 244-51.
Fadda GL, et al. Multiparametric Statistical Correlations Between Paranasal Sinus Anatomic Variations and Chronic Rhinosinusitis. Acta Otorhinolaryngol Ital. 2012;32(4):244-51. PubMed PMID: 23093814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiparametric statistical correlations between paranasal sinus anatomic variations and chronic rhinosinusitis. AU - Fadda,G L, AU - Rosso,S, AU - Aversa,S, AU - Petrelli,A, AU - Ondolo,C, AU - Succo,G, PY - 2011/11/23/received PY - 2012/03/09/accepted PY - 2012/10/25/entrez PY - 2012/10/25/pubmed PY - 2013/12/16/medline KW - Anatomic variations KW - Chronic rhinosinusitis KW - Computed tomography KW - Endoscopic sinus surgery KW - Paranasal sinuses SP - 244 EP - 51 JF - Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale JO - Acta Otorhinolaryngol Ital VL - 32 IS - 4 N2 - Improvements in functional endoscopic sinus surgery (FESS) and computed tomography (CT) have concurrently increased interest in the anatomy of the paranasal region. Common anatomical variations are not rare in patients with chronic paranasal sinusitis. The aim of this retrospective study was to analyze the incidence of anatomic variations of the lateral nasal wall in a series of 200 patients with persistent symptoms of rhinosinusitis, after failure of medical therapies, and their correlation with paranasal sinus disease. A detailed analysis of CT scans showed that 140 of 200 (70%) patients had anatomic variations. In particular, 122 patients (87%) were affected by common anatomic variations, and 18 patients (13%) with uncommon variations. There were 85 (60.7%) male and 55 (39.3%) females with ages ranging from 13 to 77 years (mean 45.5 years). The maxillary sinus was most commonly involved, followed by the anterior ethmoid, frontal sinus, posterior ethmoid and sphenoid sinus. Statistically significant association was found between the presence of common anatomic variations - septal deviation, bilateral concha bullosa, medial deviation of uncinate process, Haller cell, ethmoidal bulla hypertrophic, agger nasi cell - and the presence of sinus mucosal disease (p < 0.05). There was no significant correlation between other common and uncommon anatomic variations and mucosal pathologies. The associations were evaluated using the Fisher's exact test, and compared with those reported in the literature. Considering the results obtained, we believe that some anatomic variations may increase the risk of sinus mucosal disease. We therefore emphasize the importance of a careful evaluation of CT study in patients with persistent symptoms and recurrent chronic rhinosinusitis in order to identify those with anatomical variations that may have an increased risk of developing rhinosinusitis. SN - 1827-675X UR - https://www.unboundmedicine.com/medline/citation/23093814/Multiparametric_statistical_correlations_between_paranasal_sinus_anatomic_variations_and_chronic_rhinosinusitis_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23093814/ DB - PRIME DP - Unbound Medicine ER -