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Therapeutic modalities for localized psoriasis: 308-nm UVB excimer laser versus nontargeted phototherapy.
Cutis. 2012 Sep; 90(3):149-54.C

Abstract

UVB phototherapy is an effective treatment modality for psoriasis. For patients with localized plaque-type lesions, 308-nm excimer laser phototherapy offers rapidly delivered, targeted, high UVB doses, while sparing adjacent healthy skin. We aimed to compare the advantages and disadvantages of the 308-nm xenon chloride (XeCI) UVB excimer laser with nontargeted broadband UVB (BB-UVB), narrowband UVB (NB-UVB), and psoralen plus UVA (PUVA) phototherapies. A PubMed search for studies evaluating the efficacy and safety of the laser versus nontargeted phototherapeutic modalities was conducted. Three prospective nonrandomized studies compared NB-UVB with excimer laser phototherapy. No head-to-head studies were found for BB-UVB or PUVA compared to excimer laser. Both the 308-nm excimer laser and nontargeted phototherapies were found to effectively clear localized psoriasis. Although it is proposed that excimer laser exclusively treats diseased skin with better response rates, split-body trials revealed no differences. Long-term studies are necessary to compare the effects of high-dose excimer laser regimens with nontargeted phototherapies.

Authors+Show Affiliations

Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1071, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23094316

Citation

Mudigonda, Tejaswi, et al. "Therapeutic Modalities for Localized Psoriasis: 308-nm UVB Excimer Laser Versus Nontargeted Phototherapy." Cutis, vol. 90, no. 3, 2012, pp. 149-54.
Mudigonda T, Dabade TS, West CE, et al. Therapeutic modalities for localized psoriasis: 308-nm UVB excimer laser versus nontargeted phototherapy. Cutis. 2012;90(3):149-54.
Mudigonda, T., Dabade, T. S., West, C. E., & Feldman, S. R. (2012). Therapeutic modalities for localized psoriasis: 308-nm UVB excimer laser versus nontargeted phototherapy. Cutis, 90(3), 149-54.
Mudigonda T, et al. Therapeutic Modalities for Localized Psoriasis: 308-nm UVB Excimer Laser Versus Nontargeted Phototherapy. Cutis. 2012;90(3):149-54. PubMed PMID: 23094316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic modalities for localized psoriasis: 308-nm UVB excimer laser versus nontargeted phototherapy. AU - Mudigonda,Tejaswi, AU - Dabade,Tushar S, AU - West,Cameron E, AU - Feldman,Steven R, PY - 2012/10/26/entrez PY - 2012/10/26/pubmed PY - 2012/11/7/medline SP - 149 EP - 54 JF - Cutis JO - Cutis VL - 90 IS - 3 N2 - UVB phototherapy is an effective treatment modality for psoriasis. For patients with localized plaque-type lesions, 308-nm excimer laser phototherapy offers rapidly delivered, targeted, high UVB doses, while sparing adjacent healthy skin. We aimed to compare the advantages and disadvantages of the 308-nm xenon chloride (XeCI) UVB excimer laser with nontargeted broadband UVB (BB-UVB), narrowband UVB (NB-UVB), and psoralen plus UVA (PUVA) phototherapies. A PubMed search for studies evaluating the efficacy and safety of the laser versus nontargeted phototherapeutic modalities was conducted. Three prospective nonrandomized studies compared NB-UVB with excimer laser phototherapy. No head-to-head studies were found for BB-UVB or PUVA compared to excimer laser. Both the 308-nm excimer laser and nontargeted phototherapies were found to effectively clear localized psoriasis. Although it is proposed that excimer laser exclusively treats diseased skin with better response rates, split-body trials revealed no differences. Long-term studies are necessary to compare the effects of high-dose excimer laser regimens with nontargeted phototherapies. SN - 0011-4162 UR - https://www.unboundmedicine.com/medline/citation/23094316/Therapeutic_modalities_for_localized_psoriasis:_308_nm_UVB_excimer_laser_versus_nontargeted_phototherapy_ L2 - https://ClinicalTrials.gov/search/term=23094316 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -