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Changes in pain catastrophizing predict later changes in fibromyalgia clinical and experimental pain report: cross-lagged panel analyses of dispositional and situational catastrophizing.
Arthritis Res Ther. 2012 Oct 25; 14(5):R231.AR

Abstract

INTRODUCTION

Fibromyalgia (FM), characterized by wide-spread diffuse pain and sensory abnormalities, is associated with elevated indices of distress and pain-related catastrophizing compared to both pain-free samples and those with chronic pain conditions. Catastrophizing is a pervasive negative mental set, and is a strong predictor of negative pain-related outcomes such as clinical pain intensity, and physical disability. Situational catastrophizing, measured in the context of experimentally-induced pain, is strongly related to enhanced pain sensitivity, a core aspect of the pathophysiology of fibromyalgia. However, little is known regarding the temporal course of the association between catastrophizing and pain-related "outcomes". Most studies involve only static assessments of pain and catastrophizing at a single time point, which provides little insight into the direction of the observed associations. We sought to investigate the temporal relationships between catastrophizing and indices of both clinical pain (substudy 1) and experimentally-induced pain (substudy 2) in a larger randomized controlled longitudinal trial.

METHODS

Fifty-seven patients with FM completed catastrophizing, depression, and pain questionnaires as well as laboratory cold pressor pain testing at baseline, post-intervention and three month follow-up during a lifestyle physical activity study. Cross-lagged panel analyses were used to address these temporal relationships.

RESULTS

In substudy 1, analyses revealed that pre-to-post changes in dispositional catastrophizing ratings prospectively accounted for unique variance in subsequent post-to-follow-up changes in clinical pain ratings (p = 0.005), while pre-to-post changes in pain ratings did not account for unique variance in post-to-follow-up changes in catastrophizing ratings. An identical pattern was observed experimentally in substudy 2, with pre-to-post changes in situational catastrophizing ratings prospectively accounting for unique variance in subsequent post-to-follow-up changes in experimental pain ratings (p = 0.014), while pre-to-post changes in pain ratings did not account for unique variance in post-to-follow-up changes in catastrophizing ratings. Specifically, initial alterations in catastrophizing were associated with subsequent alterations in clinical and experimentally induced pain. Controlling for levels of depression did not affect the results.

CONCLUSIONS

These findings provide empirical evidence that catastrophizing processes might precede and contribute to subsequent alterations in the pain experience for FM patients.

TRIAL REGISTRATION

clinicaltrials.gov: NCT00383084.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23098173

Citation

Campbell, Claudia M., et al. "Changes in Pain Catastrophizing Predict Later Changes in Fibromyalgia Clinical and Experimental Pain Report: Cross-lagged Panel Analyses of Dispositional and Situational Catastrophizing." Arthritis Research & Therapy, vol. 14, no. 5, 2012, pp. R231.
Campbell CM, McCauley L, Bounds SC, et al. Changes in pain catastrophizing predict later changes in fibromyalgia clinical and experimental pain report: cross-lagged panel analyses of dispositional and situational catastrophizing. Arthritis Res Ther. 2012;14(5):R231.
Campbell, C. M., McCauley, L., Bounds, S. C., Mathur, V. A., Conn, L., Simango, M., Edwards, R. R., & Fontaine, K. R. (2012). Changes in pain catastrophizing predict later changes in fibromyalgia clinical and experimental pain report: cross-lagged panel analyses of dispositional and situational catastrophizing. Arthritis Research & Therapy, 14(5), R231. https://doi.org/10.1186/ar4073
Campbell CM, et al. Changes in Pain Catastrophizing Predict Later Changes in Fibromyalgia Clinical and Experimental Pain Report: Cross-lagged Panel Analyses of Dispositional and Situational Catastrophizing. Arthritis Res Ther. 2012 Oct 25;14(5):R231. PubMed PMID: 23098173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in pain catastrophizing predict later changes in fibromyalgia clinical and experimental pain report: cross-lagged panel analyses of dispositional and situational catastrophizing. AU - Campbell,Claudia M, AU - McCauley,Lea, AU - Bounds,Sara C, AU - Mathur,Vani A, AU - Conn,Lora, AU - Simango,Mpepera, AU - Edwards,Robert R, AU - Fontaine,Kevin R, Y1 - 2012/10/25/ PY - 2012/08/01/received PY - 2012/10/24/accepted PY - 2012/10/27/entrez PY - 2012/10/27/pubmed PY - 2015/7/22/medline SP - R231 EP - R231 JF - Arthritis research & therapy JO - Arthritis Res. Ther. VL - 14 IS - 5 N2 - INTRODUCTION: Fibromyalgia (FM), characterized by wide-spread diffuse pain and sensory abnormalities, is associated with elevated indices of distress and pain-related catastrophizing compared to both pain-free samples and those with chronic pain conditions. Catastrophizing is a pervasive negative mental set, and is a strong predictor of negative pain-related outcomes such as clinical pain intensity, and physical disability. Situational catastrophizing, measured in the context of experimentally-induced pain, is strongly related to enhanced pain sensitivity, a core aspect of the pathophysiology of fibromyalgia. However, little is known regarding the temporal course of the association between catastrophizing and pain-related "outcomes". Most studies involve only static assessments of pain and catastrophizing at a single time point, which provides little insight into the direction of the observed associations. We sought to investigate the temporal relationships between catastrophizing and indices of both clinical pain (substudy 1) and experimentally-induced pain (substudy 2) in a larger randomized controlled longitudinal trial. METHODS: Fifty-seven patients with FM completed catastrophizing, depression, and pain questionnaires as well as laboratory cold pressor pain testing at baseline, post-intervention and three month follow-up during a lifestyle physical activity study. Cross-lagged panel analyses were used to address these temporal relationships. RESULTS: In substudy 1, analyses revealed that pre-to-post changes in dispositional catastrophizing ratings prospectively accounted for unique variance in subsequent post-to-follow-up changes in clinical pain ratings (p = 0.005), while pre-to-post changes in pain ratings did not account for unique variance in post-to-follow-up changes in catastrophizing ratings. An identical pattern was observed experimentally in substudy 2, with pre-to-post changes in situational catastrophizing ratings prospectively accounting for unique variance in subsequent post-to-follow-up changes in experimental pain ratings (p = 0.014), while pre-to-post changes in pain ratings did not account for unique variance in post-to-follow-up changes in catastrophizing ratings. Specifically, initial alterations in catastrophizing were associated with subsequent alterations in clinical and experimentally induced pain. Controlling for levels of depression did not affect the results. CONCLUSIONS: These findings provide empirical evidence that catastrophizing processes might precede and contribute to subsequent alterations in the pain experience for FM patients. TRIAL REGISTRATION: clinicaltrials.gov: NCT00383084. SN - 1478-6362 UR - https://www.unboundmedicine.com/medline/citation/23098173/Changes_in_pain_catastrophizing_predict_later_changes_in_fibromyalgia_clinical_and_experimental_pain_report:_cross_lagged_panel_analyses_of_dispositional_and_situational_catastrophizing_ L2 - https://arthritis-research.biomedcentral.com/articles/10.1186/ar4073 DB - PRIME DP - Unbound Medicine ER -