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Effects of hyperosmolality and diuretics on heat-induced limb vasodilation in baboons.
Am J Physiol. 1990 Feb; 258(2 Pt 2):R309-17.AJ

Abstract

Dehydration attenuates the increase in limb skin blood flow elicited by environmental heating (EH). This study sought to determine which of the two primary effects of dehydration, increased body fluid osmolality or decreased body fluid volume, was primarily responsible for this cutaneous vasoconstrictor bias in baboons. Unanesthetized chronically instrumented baboons were exposed to EH while in euhydrated state, after 65-69 h of water deprivation (dehydration), after infusion of a small volume of hypertonic (20%) saline to raise plasma osmolality and sodium concentration to dehydration levels, and after injections of the diuretic furosemide over a 64-h period to produce an isosmotic fall in extracellular fluid volume. EH consisted of an acute elevation of ambient temperature to 39.5-42.0 degrees C until internal temperature reached 39.5-39.8 degrees C. The normal increases in external iliac artery blood flow and iliac vascular conductance during EH were unchanged by hyperosmolality but were attenuated by 39 and 31%, respectively, after furosemide treatment and by 42 and 46%, respectively, during dehydration. Thus the fall in extracellular fluid volume is the component of dehydration that attenuates the increase in hindlimb blood flow during EH in the same way as dehydration itself.

Authors+Show Affiliations

Department of Physiology, University of Texas Health Science Center, San Antonio 78284.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2309923

Citation

Proppe, D W.. "Effects of Hyperosmolality and Diuretics On Heat-induced Limb Vasodilation in Baboons." The American Journal of Physiology, vol. 258, no. 2 Pt 2, 1990, pp. R309-17.
Proppe DW. Effects of hyperosmolality and diuretics on heat-induced limb vasodilation in baboons. Am J Physiol. 1990;258(2 Pt 2):R309-17.
Proppe, D. W. (1990). Effects of hyperosmolality and diuretics on heat-induced limb vasodilation in baboons. The American Journal of Physiology, 258(2 Pt 2), R309-17.
Proppe DW. Effects of Hyperosmolality and Diuretics On Heat-induced Limb Vasodilation in Baboons. Am J Physiol. 1990;258(2 Pt 2):R309-17. PubMed PMID: 2309923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of hyperosmolality and diuretics on heat-induced limb vasodilation in baboons. A1 - Proppe,D W, PY - 1990/2/1/pubmed PY - 1990/2/1/medline PY - 1990/2/1/entrez SP - R309 EP - 17 JF - The American journal of physiology JO - Am. J. Physiol. VL - 258 IS - 2 Pt 2 N2 - Dehydration attenuates the increase in limb skin blood flow elicited by environmental heating (EH). This study sought to determine which of the two primary effects of dehydration, increased body fluid osmolality or decreased body fluid volume, was primarily responsible for this cutaneous vasoconstrictor bias in baboons. Unanesthetized chronically instrumented baboons were exposed to EH while in euhydrated state, after 65-69 h of water deprivation (dehydration), after infusion of a small volume of hypertonic (20%) saline to raise plasma osmolality and sodium concentration to dehydration levels, and after injections of the diuretic furosemide over a 64-h period to produce an isosmotic fall in extracellular fluid volume. EH consisted of an acute elevation of ambient temperature to 39.5-42.0 degrees C until internal temperature reached 39.5-39.8 degrees C. The normal increases in external iliac artery blood flow and iliac vascular conductance during EH were unchanged by hyperosmolality but were attenuated by 39 and 31%, respectively, after furosemide treatment and by 42 and 46%, respectively, during dehydration. Thus the fall in extracellular fluid volume is the component of dehydration that attenuates the increase in hindlimb blood flow during EH in the same way as dehydration itself. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/2309923/Effects_of_hyperosmolality_and_diuretics_on_heat_induced_limb_vasodilation_in_baboons_ L2 - http://journals.physiology.org/doi/full/10.1152/ajpregu.1990.258.2.R309?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -