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Effect of water or saline intake on heat-induced limb vasodilation in dehydrated baboons.
Am J Physiol. 1990 Feb; 258(2 Pt 2):R318-24.AJ

Abstract

Dehydration markedly attenuates the increase in hindlimb blood flow elicited by environmental heating (EH) in baboons. This study sought to determine the importance of gradually produced increases in body fluid osmolality and decreases in body fluid volume in producing this attenuation. The hindlimb blood flow increases during EH of seven unanesthetized chronically instrumented baboons were examined during euhydration, dehydration (64-68 h of water deprivation), and after ad libitum oral rehydration with either water or a hyperosmotic saline solution. EH consisted of acute exposure to ambient temperatures of 38-42 degrees C until internal temperature reached 39.5 degrees C. Dehydration depressed the maximal external iliac artery blood flow (MIBF) and iliac vascular conductance (IVC) attained during EH in the euhydrated state by 37 and 43%, respectively. Rehydration with either water or saline solution, however, restored maximal MIBF and IVC to euhydrated levels. Because plasma osmolality remained at dehydrated levels after rehydration with saline, hyperosmolality does not produce the dehydration-induced attenuation in hindlimb blood flow.

Authors+Show Affiliations

Department of Physiology, University of Texas Health Science Center, San Antonio 78284.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2309924

Citation

Ryan, K L., and D W. Proppe. "Effect of Water or Saline Intake On Heat-induced Limb Vasodilation in Dehydrated Baboons." The American Journal of Physiology, vol. 258, no. 2 Pt 2, 1990, pp. R318-24.
Ryan KL, Proppe DW. Effect of water or saline intake on heat-induced limb vasodilation in dehydrated baboons. Am J Physiol. 1990;258(2 Pt 2):R318-24.
Ryan, K. L., & Proppe, D. W. (1990). Effect of water or saline intake on heat-induced limb vasodilation in dehydrated baboons. The American Journal of Physiology, 258(2 Pt 2), R318-24.
Ryan KL, Proppe DW. Effect of Water or Saline Intake On Heat-induced Limb Vasodilation in Dehydrated Baboons. Am J Physiol. 1990;258(2 Pt 2):R318-24. PubMed PMID: 2309924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of water or saline intake on heat-induced limb vasodilation in dehydrated baboons. AU - Ryan,K L, AU - Proppe,D W, PY - 1990/2/1/pubmed PY - 1990/2/1/medline PY - 1990/2/1/entrez SP - R318 EP - 24 JF - The American journal of physiology JO - Am. J. Physiol. VL - 258 IS - 2 Pt 2 N2 - Dehydration markedly attenuates the increase in hindlimb blood flow elicited by environmental heating (EH) in baboons. This study sought to determine the importance of gradually produced increases in body fluid osmolality and decreases in body fluid volume in producing this attenuation. The hindlimb blood flow increases during EH of seven unanesthetized chronically instrumented baboons were examined during euhydration, dehydration (64-68 h of water deprivation), and after ad libitum oral rehydration with either water or a hyperosmotic saline solution. EH consisted of acute exposure to ambient temperatures of 38-42 degrees C until internal temperature reached 39.5 degrees C. Dehydration depressed the maximal external iliac artery blood flow (MIBF) and iliac vascular conductance (IVC) attained during EH in the euhydrated state by 37 and 43%, respectively. Rehydration with either water or saline solution, however, restored maximal MIBF and IVC to euhydrated levels. Because plasma osmolality remained at dehydrated levels after rehydration with saline, hyperosmolality does not produce the dehydration-induced attenuation in hindlimb blood flow. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/2309924/Effect_of_water_or_saline_intake_on_heat_induced_limb_vasodilation_in_dehydrated_baboons_ L2 - http://journals.physiology.org/doi/full/10.1152/ajpregu.1990.258.2.R318?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -