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ω-3 Long-Chain Polyunsaturated Fatty Acids and Fatty Acid Desaturase Activity Ratios as Eventual Endophenotypes for ADHD.
J Atten Disord. 2015 Nov; 19(11):977-86.JA

Abstract

OBJECTIVE

Epidemiological studies suggest that long-chain polyunsaturated fatty acids (LC-PUFAs) may be suitable as endophenotypes for ADHD. To be appropriated vulnerability traits, endophenotypes should be altered in unaffected relatives of index cases. Serum profiles of LC-PUFAs in unaffected relatives of ADHD patients remain understudied. The main objective of this study was to compare serum LC-PUFAs in ADHD patients, unaffected relatives of index cases, and general-population unaffected participants.

METHOD

LC-PUFA profiles of 72 participants (27 ADHD patients, 27 unaffected relatives, and 18 general-population participants) were obtained by gas chromatography-mass spectrometry (GC-MS). Groups were compared by parametrical statistics.

RESULTS

Unaffected females from the general population presented lower Docosapentaenoic acid (DPA; p = .0012) and a-linolenic acid (ALA; p = .0091) levels compared with ADHD females and unaffected relatives. In addition, docosahexaenoic acid (DHA)/ALA and DHA/DPA ratios, addressing desaturase activity, were significantly lower in ADHD patients and unaffected relatives of ADHD patients in the female-subgroup (p = .022 and .04, respectively).

CONCLUSION

DHA/ALA, DHA/DPA, serum DPA, and serum ALA may be suitable as endophenotypes for ADHD women.

Authors+Show Affiliations

Pontificia Universidad Católica de Chile, Santiago, Chile mhenri@med.puc.cl.Pontificia Universidad Católica de Chile, Santiago, Chile.Pontificia Universidad Católica de Chile, Santiago, Chile.Pontificia Universidad Católica de Chile, Santiago, Chile.Pontificia Universidad Católica de Chile, Santiago, Chile.Pontificia Universidad Católica de Chile, Santiago, Chile.Pontificia Universidad Católica de Chile, Santiago, Chile.Pontificia Universidad Católica de Chile, Santiago, Chile.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23100268

Citation

Henríquez-Henríquez, Marcela, et al. "Ω-3 Long-Chain Polyunsaturated Fatty Acids and Fatty Acid Desaturase Activity Ratios as Eventual Endophenotypes for ADHD." Journal of Attention Disorders, vol. 19, no. 11, 2015, pp. 977-86.
Henríquez-Henríquez M, Solari S, Várgas G, et al. Ω-3 Long-Chain Polyunsaturated Fatty Acids and Fatty Acid Desaturase Activity Ratios as Eventual Endophenotypes for ADHD. J Atten Disord. 2015;19(11):977-86.
Henríquez-Henríquez, M., Solari, S., Várgas, G., Vásquez, L., Allende, F., Castañón S, C., Tenorio, M., & Quiroga Gutiérrez, T. (2015). Ω-3 Long-Chain Polyunsaturated Fatty Acids and Fatty Acid Desaturase Activity Ratios as Eventual Endophenotypes for ADHD. Journal of Attention Disorders, 19(11), 977-86. https://doi.org/10.1177/1087054712461175
Henríquez-Henríquez M, et al. Ω-3 Long-Chain Polyunsaturated Fatty Acids and Fatty Acid Desaturase Activity Ratios as Eventual Endophenotypes for ADHD. J Atten Disord. 2015;19(11):977-86. PubMed PMID: 23100268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ω-3 Long-Chain Polyunsaturated Fatty Acids and Fatty Acid Desaturase Activity Ratios as Eventual Endophenotypes for ADHD. AU - Henríquez-Henríquez,Marcela, AU - Solari,Sandra, AU - Várgas,Gisela, AU - Vásquez,Luis, AU - Allende,Fidel, AU - Castañón S,Carla, AU - Tenorio,Marcela, AU - Quiroga Gutiérrez,Teresa, Y1 - 2012/10/25/ PY - 2012/10/27/entrez PY - 2012/10/27/pubmed PY - 2016/4/19/medline KW - ADHD KW - LC-PUFAs KW - endophenotype KW - ω-3 SP - 977 EP - 86 JF - Journal of attention disorders JO - J Atten Disord VL - 19 IS - 11 N2 - OBJECTIVE: Epidemiological studies suggest that long-chain polyunsaturated fatty acids (LC-PUFAs) may be suitable as endophenotypes for ADHD. To be appropriated vulnerability traits, endophenotypes should be altered in unaffected relatives of index cases. Serum profiles of LC-PUFAs in unaffected relatives of ADHD patients remain understudied. The main objective of this study was to compare serum LC-PUFAs in ADHD patients, unaffected relatives of index cases, and general-population unaffected participants. METHOD: LC-PUFA profiles of 72 participants (27 ADHD patients, 27 unaffected relatives, and 18 general-population participants) were obtained by gas chromatography-mass spectrometry (GC-MS). Groups were compared by parametrical statistics. RESULTS: Unaffected females from the general population presented lower Docosapentaenoic acid (DPA; p = .0012) and a-linolenic acid (ALA; p = .0091) levels compared with ADHD females and unaffected relatives. In addition, docosahexaenoic acid (DHA)/ALA and DHA/DPA ratios, addressing desaturase activity, were significantly lower in ADHD patients and unaffected relatives of ADHD patients in the female-subgroup (p = .022 and .04, respectively). CONCLUSION: DHA/ALA, DHA/DPA, serum DPA, and serum ALA may be suitable as endophenotypes for ADHD women. SN - 1557-1246 UR - https://www.unboundmedicine.com/medline/citation/23100268/ω_3_Long_Chain_Polyunsaturated_Fatty_Acids_and_Fatty_Acid_Desaturase_Activity_Ratios_as_Eventual_Endophenotypes_for_ADHD_ L2 - https://journals.sagepub.com/doi/10.1177/1087054712461175?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -