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Histologic findings in alcoholic liver disease.
Clin Liver Dis. 2012 Nov; 16(4):699-716.CL

Abstract

The necessity of the liver being the organ responsible for metabolism of alcohol exposes it to many untoward toxic side effects. In the first instance of hepatic steatosis, fibrosis may occur indolently over years, slowly converting a greasy, steatotic liver into a cirrhotic liver. In the case of alcoholic hepatitis, brisk sinusoidal fibrosis may lead to more rapid development of cirrhosis, with the liver extensively subdivided by sublobular fibrous septa developing in the midst of extensive ongoing inflammation and hepatocellular destruction. Continued destruction of the parenchyma after cirrhosis has developed may produce a densely fibrotic organ with little remaining parenchyma.

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Authors+Show Affiliations

Crawford JM
Department of Pathology and Laboratory Medicine, Hofstra North Shore-LIJ School of Medicine, Uniondale, NY, USA. jcrawford1@nshs.edu

MeSH

ApoptosisDiagnosis, DifferentialDisease ProgressionFatty Liver, AlcoholicHepatic Stellate CellsHepatitis, AlcoholicHepatocytesHumansInflammationLipid MetabolismLiver Cirrhosis, AlcoholicLiver Diseases, AlcoholicLiver RegenerationMallory BodiesNecrosis

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23101978

Citation

Crawford, James M.. "Histologic Findings in Alcoholic Liver Disease." Clinics in Liver Disease, vol. 16, no. 4, 2012, pp. 699-716.
Crawford JM. Histologic findings in alcoholic liver disease. Clin Liver Dis. 2012;16(4):699-716.
Crawford, J. M. (2012). Histologic findings in alcoholic liver disease. Clinics in Liver Disease, 16(4), 699-716. https://doi.org/10.1016/j.cld.2012.08.004
Crawford JM. Histologic Findings in Alcoholic Liver Disease. Clin Liver Dis. 2012;16(4):699-716. PubMed PMID: 23101978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histologic findings in alcoholic liver disease. A1 - Crawford,James M, PY - 2012/10/30/entrez PY - 2012/10/30/pubmed PY - 2013/4/13/medline SP - 699 EP - 716 JF - Clinics in liver disease JO - Clin Liver Dis VL - 16 IS - 4 N2 - The necessity of the liver being the organ responsible for metabolism of alcohol exposes it to many untoward toxic side effects. In the first instance of hepatic steatosis, fibrosis may occur indolently over years, slowly converting a greasy, steatotic liver into a cirrhotic liver. In the case of alcoholic hepatitis, brisk sinusoidal fibrosis may lead to more rapid development of cirrhosis, with the liver extensively subdivided by sublobular fibrous septa developing in the midst of extensive ongoing inflammation and hepatocellular destruction. Continued destruction of the parenchyma after cirrhosis has developed may produce a densely fibrotic organ with little remaining parenchyma. SN - 1557-8224 UR - https://www.unboundmedicine.com/medline/citation/23101978/Histologic_findings_in_alcoholic_liver_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1089-3261(12)00087-6 DB - PRIME DP - Unbound Medicine ER -