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Identification of oxytocin receptor in the dorsal horn and nociceptive dorsal root ganglion neurons.
Neuropeptides. 2013 Apr; 47(2):117-23.N

Abstract

Oxytocin (OT) secreted by the hypothalamo-spinal projection exerts antinociceptive effects in the dorsal horn. Electrophysiological evidence indicates that OT could exert these effects by activating OT receptors (OTR) directly on dorsal horn neurons and/or primary nociceptive afferents in the dorsal root ganglia (DRG). However, little is known about the identity of the dorsal horn and DRG neurons that express the OTR. In the dorsal horn, we found that the OTR is expressed principally in neurons cell bodies. However, neither spino-thalamic dorsal horn neurons projecting to the contralateral thalamic ventral posterolateral nucleus (VPL) and posterior nuclear group (Po) nor GABaergic dorsal horn neurons express the OTR. The OTR is not expressed in skin nociceptive terminals or in dorsal horn nociceptive fibers. In the DRG, however, the OTR is expressed predominantly in non-peptidergic C-fiber cell bodies, but not in peptidergic or mechanoreceptor afferents or in skin nociceptive terminals. Our results suggest that the antinociceptive effects of OT are mediated by direct activation of dorsal horn neurons and peripheral actions on nociceptive, non-peptidergic C-afferents in the DRG.

Authors+Show Affiliations

Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Querétaro, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23102456

Citation

Moreno-López, Y, et al. "Identification of Oxytocin Receptor in the Dorsal Horn and Nociceptive Dorsal Root Ganglion Neurons." Neuropeptides, vol. 47, no. 2, 2013, pp. 117-23.
Moreno-López Y, Martínez-Lorenzana G, Condés-Lara M, et al. Identification of oxytocin receptor in the dorsal horn and nociceptive dorsal root ganglion neurons. Neuropeptides. 2013;47(2):117-23.
Moreno-López, Y., Martínez-Lorenzana, G., Condés-Lara, M., & Rojas-Piloni, G. (2013). Identification of oxytocin receptor in the dorsal horn and nociceptive dorsal root ganglion neurons. Neuropeptides, 47(2), 117-23. https://doi.org/10.1016/j.npep.2012.09.008
Moreno-López Y, et al. Identification of Oxytocin Receptor in the Dorsal Horn and Nociceptive Dorsal Root Ganglion Neurons. Neuropeptides. 2013;47(2):117-23. PubMed PMID: 23102456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of oxytocin receptor in the dorsal horn and nociceptive dorsal root ganglion neurons. AU - Moreno-López,Y, AU - Martínez-Lorenzana,G, AU - Condés-Lara,M, AU - Rojas-Piloni,G, Y1 - 2012/10/24/ PY - 2012/05/02/received PY - 2012/09/11/revised PY - 2012/09/11/accepted PY - 2012/10/30/entrez PY - 2012/10/30/pubmed PY - 2013/8/31/medline SP - 117 EP - 23 JF - Neuropeptides JO - Neuropeptides VL - 47 IS - 2 N2 - Oxytocin (OT) secreted by the hypothalamo-spinal projection exerts antinociceptive effects in the dorsal horn. Electrophysiological evidence indicates that OT could exert these effects by activating OT receptors (OTR) directly on dorsal horn neurons and/or primary nociceptive afferents in the dorsal root ganglia (DRG). However, little is known about the identity of the dorsal horn and DRG neurons that express the OTR. In the dorsal horn, we found that the OTR is expressed principally in neurons cell bodies. However, neither spino-thalamic dorsal horn neurons projecting to the contralateral thalamic ventral posterolateral nucleus (VPL) and posterior nuclear group (Po) nor GABaergic dorsal horn neurons express the OTR. The OTR is not expressed in skin nociceptive terminals or in dorsal horn nociceptive fibers. In the DRG, however, the OTR is expressed predominantly in non-peptidergic C-fiber cell bodies, but not in peptidergic or mechanoreceptor afferents or in skin nociceptive terminals. Our results suggest that the antinociceptive effects of OT are mediated by direct activation of dorsal horn neurons and peripheral actions on nociceptive, non-peptidergic C-afferents in the DRG. SN - 1532-2785 UR - https://www.unboundmedicine.com/medline/citation/23102456/Identification_of_oxytocin_receptor_in_the_dorsal_horn_and_nociceptive_dorsal_root_ganglion_neurons_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0143-4179(12)00104-7 DB - PRIME DP - Unbound Medicine ER -