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Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents.
Bioorg Med Chem Lett. 2012 Dec 15; 22(24):7659-61.BM

Abstract

New 7-acyl camptothecin derivatives were designed and synthesized from camptothecin in a one-pot reaction through a Minisci type-reaction and were evaluated for cytotoxicity against four tumor cell lines, A-549, DU-145, KB, and KB-vin. All of the new compounds showed significant inhibition of human tumor cell growth, with IC(50) values ranging from 0.01538 to 13.342 μM. Most of the derivatives were more cytotoxic than irinotecan, and the (7a) and 7-propionyl (7b) analogs exhibited the highest cytotoxic activity against the tumor cell lines tested. This compound class merits further development as anticancer clinical trial candidates.

Authors+Show Affiliations

School of Pharmacy, Lanzhou University, Lanzhou 730000, PR China. yqliu@lzu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23102893

Citation

Liu, Ying-Qian, et al. "Design and One-pot Synthesis of New 7-acyl Camptothecin Derivatives as Potent Cytotoxic Agents." Bioorganic & Medicinal Chemistry Letters, vol. 22, no. 24, 2012, pp. 7659-61.
Liu YQ, Dai W, Wang CY, et al. Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents. Bioorg Med Chem Lett. 2012;22(24):7659-61.
Liu, Y. Q., Dai, W., Wang, C. Y., Morris-Natschke, S. L., Zhou, X. W., Yang, L., Yang, X. M., Li, W. Q., & Lee, K. H. (2012). Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents. Bioorganic & Medicinal Chemistry Letters, 22(24), 7659-61. https://doi.org/10.1016/j.bmcl.2012.10.002
Liu YQ, et al. Design and One-pot Synthesis of New 7-acyl Camptothecin Derivatives as Potent Cytotoxic Agents. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7659-61. PubMed PMID: 23102893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents. AU - Liu,Ying-Qian, AU - Dai,Wei, AU - Wang,Chih-Ya, AU - Morris-Natschke,Susan L, AU - Zhou,Xing-Wen, AU - Yang,Liu, AU - Yang,Xiao-Ming, AU - Li,Wen-Qun, AU - Lee,Kuo-Hsiung, Y1 - 2012/10/11/ PY - 2012/07/16/received PY - 2012/09/24/revised PY - 2012/10/01/accepted PY - 2012/10/30/entrez PY - 2012/10/30/pubmed PY - 2013/5/22/medline SP - 7659 EP - 61 JF - Bioorganic & medicinal chemistry letters JO - Bioorg. Med. Chem. Lett. VL - 22 IS - 24 N2 - New 7-acyl camptothecin derivatives were designed and synthesized from camptothecin in a one-pot reaction through a Minisci type-reaction and were evaluated for cytotoxicity against four tumor cell lines, A-549, DU-145, KB, and KB-vin. All of the new compounds showed significant inhibition of human tumor cell growth, with IC(50) values ranging from 0.01538 to 13.342 μM. Most of the derivatives were more cytotoxic than irinotecan, and the (7a) and 7-propionyl (7b) analogs exhibited the highest cytotoxic activity against the tumor cell lines tested. This compound class merits further development as anticancer clinical trial candidates. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/23102893/Design_and_one_pot_synthesis_of_new_7_acyl_camptothecin_derivatives_as_potent_cytotoxic_agents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(12)01269-3 DB - PRIME DP - Unbound Medicine ER -