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[BMP signaling and bone formation].
Clin Calcium. 2012 Nov; 22(11):1677-83.CC

Abstract

Bone morphogenetic proteins (BMPs) bind to two types of membrane receptors. Type II receptor phosphorylates type I receptor, then the phosphorylated type I receptor phosphorylates downstream effectors, such as Smads. Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by progressive heterotopic ossification in skeletal muscle tissue. ALK2, a BMP type I receptor has been mutated in patients with FOP. The mutant ALK2 phosphorylates Smads in the absence of BMPs. In FOP, muscle injury may enhance BMP signaling via Smads to induce acute heterotopic ossification. Inhibitors of the BMP-Smad pathway will be useful to develop novel treatments for FOP.

Authors+Show Affiliations

Saitama Medical University, Japan.

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

23103811

Citation

Katagiri, Takenobu. "[BMP Signaling and Bone Formation]." Clinical Calcium, vol. 22, no. 11, 2012, pp. 1677-83.
Katagiri T. [BMP signaling and bone formation]. Clin Calcium. 2012;22(11):1677-83.
Katagiri, T. (2012). [BMP signaling and bone formation]. Clinical Calcium, 22(11), 1677-83. https://doi.org/CliCa121116771683
Katagiri T. [BMP Signaling and Bone Formation]. Clin Calcium. 2012;22(11):1677-83. PubMed PMID: 23103811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [BMP signaling and bone formation]. A1 - Katagiri,Takenobu, PY - 2012/10/30/entrez PY - 2012/10/30/pubmed PY - 2013/3/21/medline SP - 1677 EP - 83 JF - Clinical calcium JO - Clin Calcium VL - 22 IS - 11 N2 - Bone morphogenetic proteins (BMPs) bind to two types of membrane receptors. Type II receptor phosphorylates type I receptor, then the phosphorylated type I receptor phosphorylates downstream effectors, such as Smads. Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by progressive heterotopic ossification in skeletal muscle tissue. ALK2, a BMP type I receptor has been mutated in patients with FOP. The mutant ALK2 phosphorylates Smads in the absence of BMPs. In FOP, muscle injury may enhance BMP signaling via Smads to induce acute heterotopic ossification. Inhibitors of the BMP-Smad pathway will be useful to develop novel treatments for FOP. SN - 0917-5857 UR - https://www.unboundmedicine.com/medline/citation/23103811/[BMP_signaling_and_bone_formation]_ DB - PRIME DP - Unbound Medicine ER -