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Inflammatory bowel disease has a small effect on bone mineral density and risk for osteoporosis.
Clin Gastroenterol Hepatol. 2013 Mar; 11(3):278-85.CG

Abstract

BACKGROUND & AIMS

A high prevalence of osteoporosis has been reported among individuals with inflammatory bowel disease (IBD). We performed a population-based analysis to determine whether IBD is itself a risk factor for low bone mineral density (BMD) or whether low BMD results from other factors associated with IBD.

METHODS

We identified 1230 subjects with IBD in the Manitoba BMD Database, which contains results of BMD tests performed on all Manitobans since 1997 (n = 45,714). BMD was assessed at the lumbar spine (mean value, L1-L4), hip (total), femoral neck, and trochanter. Multivariate linear and logistic regression analyses were performed to determine the independent effects of IBD, Crohn's disease (CD), or ulcerative colitis (UC) on T score and the presence of osteoporosis (a low T score was equal to or less than -2.5) at any site; we controlled for age, sex, body mass index, hormone replacement therapy, osteoprotective medications, and corticosteroid use. We also performed regression analysis within the IBD population to determine the effect of IBD-specific factors on T score and osteoporosis.

RESULTS

IBD was associated with a statistically significant but small effect on T score; IBD did not increase the risk for osteoporosis at any site measured. CD was associated with an increased risk of osteoporosis at the lumbar spine and trochanter, but UC was not associated with an increased risk of osteoporosis or low T score. No IBD-specific variables were associated with increased risk of osteoporosis or low T score.

CONCLUSIONS

IBD has a small effect on BMD; CD poses a greater risk than UC. The risk of osteoporosis in patients with IBD appears to be related to other known osteoporosis risk factors.

Authors+Show Affiliations

Section of Gastroenterology, University of Manitoba, Winnipeg, Canada. Laura.Targownik@med.unanitoba.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23103821

Citation

Targownik, Laura E., et al. "Inflammatory Bowel Disease Has a Small Effect On Bone Mineral Density and Risk for Osteoporosis." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 11, no. 3, 2013, pp. 278-85.
Targownik LE, Bernstein CN, Nugent Z, et al. Inflammatory bowel disease has a small effect on bone mineral density and risk for osteoporosis. Clin Gastroenterol Hepatol. 2013;11(3):278-85.
Targownik, L. E., Bernstein, C. N., Nugent, Z., & Leslie, W. D. (2013). Inflammatory bowel disease has a small effect on bone mineral density and risk for osteoporosis. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 11(3), 278-85. https://doi.org/10.1016/j.cgh.2012.10.022
Targownik LE, et al. Inflammatory Bowel Disease Has a Small Effect On Bone Mineral Density and Risk for Osteoporosis. Clin Gastroenterol Hepatol. 2013;11(3):278-85. PubMed PMID: 23103821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammatory bowel disease has a small effect on bone mineral density and risk for osteoporosis. AU - Targownik,Laura E, AU - Bernstein,Charles N, AU - Nugent,Zoann, AU - Leslie,William D, Y1 - 2012/10/26/ PY - 2012/06/26/received PY - 2012/10/02/revised PY - 2012/10/15/accepted PY - 2012/10/30/entrez PY - 2012/10/30/pubmed PY - 2013/8/21/medline SP - 278 EP - 85 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. VL - 11 IS - 3 N2 - BACKGROUND & AIMS: A high prevalence of osteoporosis has been reported among individuals with inflammatory bowel disease (IBD). We performed a population-based analysis to determine whether IBD is itself a risk factor for low bone mineral density (BMD) or whether low BMD results from other factors associated with IBD. METHODS: We identified 1230 subjects with IBD in the Manitoba BMD Database, which contains results of BMD tests performed on all Manitobans since 1997 (n = 45,714). BMD was assessed at the lumbar spine (mean value, L1-L4), hip (total), femoral neck, and trochanter. Multivariate linear and logistic regression analyses were performed to determine the independent effects of IBD, Crohn's disease (CD), or ulcerative colitis (UC) on T score and the presence of osteoporosis (a low T score was equal to or less than -2.5) at any site; we controlled for age, sex, body mass index, hormone replacement therapy, osteoprotective medications, and corticosteroid use. We also performed regression analysis within the IBD population to determine the effect of IBD-specific factors on T score and osteoporosis. RESULTS: IBD was associated with a statistically significant but small effect on T score; IBD did not increase the risk for osteoporosis at any site measured. CD was associated with an increased risk of osteoporosis at the lumbar spine and trochanter, but UC was not associated with an increased risk of osteoporosis or low T score. No IBD-specific variables were associated with increased risk of osteoporosis or low T score. CONCLUSIONS: IBD has a small effect on BMD; CD poses a greater risk than UC. The risk of osteoporosis in patients with IBD appears to be related to other known osteoporosis risk factors. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/23103821/Inflammatory_bowel_disease_has_a_small_effect_on_bone_mineral_density_and_risk_for_osteoporosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(12)01277-3 DB - PRIME DP - Unbound Medicine ER -