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Development of pH-sensitive pectinate/alginate microspheres for colon drug delivery.
J Mater Sci Mater Med. 2013 Feb; 24(2):317-23.JM

Abstract

The purposes of this study were to develop and evaluate calcium pectinate/alginate microspheres (PAMs) and to exploit their pH-sensitive properties for colon-targeted delivery of encapsulated cisplatin. PAMs were prepared using an electrospraying method. The PAMs, as cores, were then coated with Eudragit S100 using a polyelectrolyte multilayer coating technique in aqueous solution. The morphology of the microspheres was observed under scanning electron microscopy. In vitro drug release studies were performed in simulated gastrointestinal fluid, and the results indicated that approximately 5 % of the cisplatin was released from the Eudragit S100-coated PAMs, and 51 % of the cisplatin was released from the uncoated PAMs at 1 h. The release of cisplatin from the Eudragit S100-coated PAMs was more sustained in simulated gastric fluid than in simulated intestinal fluid due to the increased solubility of the coating polymer in media with pH >7.0. Drug release from the Eudragit S100-coated PAMs was best described by the Higuchi's square root model. From these results, it was concluded that Eudragit S100-coated PAMs are a potential carrier for delivery of cisplatin to the colon.

Authors+Show Affiliations

Department of Life Sciences, National Taiwan Ocean University, Keelung, Taiwan, ROC. fyhsu5565@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23104086

Citation

Hsu, Fu-Yin, et al. "Development of pH-sensitive Pectinate/alginate Microspheres for Colon Drug Delivery." Journal of Materials Science. Materials in Medicine, vol. 24, no. 2, 2013, pp. 317-23.
Hsu FY, Yu DS, Huang CC. Development of pH-sensitive pectinate/alginate microspheres for colon drug delivery. J Mater Sci Mater Med. 2013;24(2):317-23.
Hsu, F. Y., Yu, D. S., & Huang, C. C. (2013). Development of pH-sensitive pectinate/alginate microspheres for colon drug delivery. Journal of Materials Science. Materials in Medicine, 24(2), 317-23. https://doi.org/10.1007/s10856-012-4798-9
Hsu FY, Yu DS, Huang CC. Development of pH-sensitive Pectinate/alginate Microspheres for Colon Drug Delivery. J Mater Sci Mater Med. 2013;24(2):317-23. PubMed PMID: 23104086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of pH-sensitive pectinate/alginate microspheres for colon drug delivery. AU - Hsu,Fu-Yin, AU - Yu,Ding-Syuan, AU - Huang,Chun-Chiang, Y1 - 2012/10/27/ PY - 2012/07/03/received PY - 2012/10/15/accepted PY - 2012/10/30/entrez PY - 2012/10/30/pubmed PY - 2013/9/14/medline SP - 317 EP - 23 JF - Journal of materials science. Materials in medicine JO - J Mater Sci Mater Med VL - 24 IS - 2 N2 - The purposes of this study were to develop and evaluate calcium pectinate/alginate microspheres (PAMs) and to exploit their pH-sensitive properties for colon-targeted delivery of encapsulated cisplatin. PAMs were prepared using an electrospraying method. The PAMs, as cores, were then coated with Eudragit S100 using a polyelectrolyte multilayer coating technique in aqueous solution. The morphology of the microspheres was observed under scanning electron microscopy. In vitro drug release studies were performed in simulated gastrointestinal fluid, and the results indicated that approximately 5 % of the cisplatin was released from the Eudragit S100-coated PAMs, and 51 % of the cisplatin was released from the uncoated PAMs at 1 h. The release of cisplatin from the Eudragit S100-coated PAMs was more sustained in simulated gastric fluid than in simulated intestinal fluid due to the increased solubility of the coating polymer in media with pH >7.0. Drug release from the Eudragit S100-coated PAMs was best described by the Higuchi's square root model. From these results, it was concluded that Eudragit S100-coated PAMs are a potential carrier for delivery of cisplatin to the colon. SN - 1573-4838 UR - https://www.unboundmedicine.com/medline/citation/23104086/Development_of_pH_sensitive_pectinate/alginate_microspheres_for_colon_drug_delivery_ L2 - https://doi.org/10.1007/s10856-012-4798-9 DB - PRIME DP - Unbound Medicine ER -