Type your tag names separated by a space and hit enter

Behavioral and monoamine changes following severe vitamin C deficiency.


Severe vitamin C deficiency (ascorbic acid; AA) was induced in gulo-/- mice incapable of synthesizing their own AA. A number of behavioral measures were studied before and during the deprivation period, including a scorbutic period, during which weight loss was observed in the mice. Mice were then resuscitated with AA supplements. During the scorbutic period, gulo-/- mice showed decreased voluntary locomotor activity, diminished physical strength, and increased preference for a highly palatable sucrose reward. These behaviors all returned to control levels following resuscitation. Altered trial times in subordinate mice in the tube test for social dominance in the AA-deprived mice persisted following resuscitation and may signify a depressive-like behavior in these mice. Biochemical analyses were undertaken following a second deprivation period. AA deficiency was accompanied by decreased blood glucose levels, oxidative damage to lipids and proteins in the cortex, and decreases in dopamine and serotonin metabolites in both the cortex and striatum. Given the reasonably high proportions of the population that do not consume sufficient AA in the diet, these data have important implications for physical and psychological function in the general population.


  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors+Show Affiliations


    Department of Neuroscience, Vanderbilt University, Nashville, TN, USA.

    , ,


    Journal of neurochemistry 124:3 2013 Feb pg 363-75


    Ascorbic Acid
    Ascorbic Acid Deficiency
    Behavior, Animal
    Biogenic Monoamines
    Disease Models, Animal
    L-Gulonolactone Oxidase
    Mice, Inbred C57BL
    Mice, Knockout
    Severity of Illness Index

    Pub Type(s)

    Journal Article



    PubMed ID