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Gender differences in the association of insulin resistance with metabolic risk factors among Korean adolescents: Korea National Health and Nutrition Examination Survey 2008-2010.
Diabetes Res Clin Pract 2013; 99(1):54-62DR

Abstract

AIMS

We investigated the association of insulin resistance with metabolic syndrome (MetS) and its components among Korean adolescents.

METHODS

We analyzed the Korea National Health and Nutrition Examination Survey (2008-2010). Adolescents aged 10-18 years without diabetes (1584 boys and 1388 girls) were evaluated. Insulin resistance was assessed by homeostasis model assessment-insulin resistance (HOMA-IR), and MetS was diagnosed according to the 2007 International Diabetes Federation criteria for adolescents.

RESULTS

The prevalence of MetS was 1.4% among boys and 1.7% among girls. Girls in the highest quartile of HOMA-IR were significantly more likely to have MetS compared to girls in the lower quartiles independent of survey year, age, body mass index, white blood cell count, and alanine aminotransferase [odds ratio (OR), 5.33; 95% confidence interval (CI), 1.57-18.11]. Moreover, compared to girls in the lowest quartile of HOMA-IR, girls in the highest quartile significantly exhibited large waist circumference (OR, 3.22; 95% CI, 1.01-10.35), high triglycerides (OR, 6.43; 95% CI, 2.83-14.58), and low high-density lipoprotein-cholesterol (HDL-C) (OR, 2.49; 95% CI, 1.50-4.11). However, such associations were not found among boys.

CONCLUSIONS

Our results suggest that insulin resistance may be independently associated with MetS, large waist circumference, high triglycerides, and low HDL-C only among girls.

Authors+Show Affiliations

College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23107107

Citation

Kim, Hyun-Ah, et al. "Gender Differences in the Association of Insulin Resistance With Metabolic Risk Factors Among Korean Adolescents: Korea National Health and Nutrition Examination Survey 2008-2010." Diabetes Research and Clinical Practice, vol. 99, no. 1, 2013, pp. 54-62.
Kim HA, Lee SY, Kwon HS, et al. Gender differences in the association of insulin resistance with metabolic risk factors among Korean adolescents: Korea National Health and Nutrition Examination Survey 2008-2010. Diabetes Res Clin Pract. 2013;99(1):54-62.
Kim, H. A., Lee, S. Y., Kwon, H. S., Lee, S. H., Jung, M. H., Han, K., ... Park, Y. M. (2013). Gender differences in the association of insulin resistance with metabolic risk factors among Korean adolescents: Korea National Health and Nutrition Examination Survey 2008-2010. Diabetes Research and Clinical Practice, 99(1), pp. 54-62. doi:10.1016/j.diabres.2012.10.011.
Kim HA, et al. Gender Differences in the Association of Insulin Resistance With Metabolic Risk Factors Among Korean Adolescents: Korea National Health and Nutrition Examination Survey 2008-2010. Diabetes Res Clin Pract. 2013;99(1):54-62. PubMed PMID: 23107107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender differences in the association of insulin resistance with metabolic risk factors among Korean adolescents: Korea National Health and Nutrition Examination Survey 2008-2010. AU - Kim,Hyun-Ah, AU - Lee,Sae-Young, AU - Kwon,Hyuk-Sang, AU - Lee,Seung-Hwan, AU - Jung,Min Ho, AU - Han,Kyungdo, AU - Yim,Hyeon Woo, AU - Lee,Won-Chul, AU - Park,Yong-Moon, Y1 - 2012/10/27/ PY - 2012/05/15/received PY - 2012/09/03/revised PY - 2012/10/05/accepted PY - 2012/10/31/entrez PY - 2012/10/31/pubmed PY - 2013/5/18/medline SP - 54 EP - 62 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 99 IS - 1 N2 - AIMS: We investigated the association of insulin resistance with metabolic syndrome (MetS) and its components among Korean adolescents. METHODS: We analyzed the Korea National Health and Nutrition Examination Survey (2008-2010). Adolescents aged 10-18 years without diabetes (1584 boys and 1388 girls) were evaluated. Insulin resistance was assessed by homeostasis model assessment-insulin resistance (HOMA-IR), and MetS was diagnosed according to the 2007 International Diabetes Federation criteria for adolescents. RESULTS: The prevalence of MetS was 1.4% among boys and 1.7% among girls. Girls in the highest quartile of HOMA-IR were significantly more likely to have MetS compared to girls in the lower quartiles independent of survey year, age, body mass index, white blood cell count, and alanine aminotransferase [odds ratio (OR), 5.33; 95% confidence interval (CI), 1.57-18.11]. Moreover, compared to girls in the lowest quartile of HOMA-IR, girls in the highest quartile significantly exhibited large waist circumference (OR, 3.22; 95% CI, 1.01-10.35), high triglycerides (OR, 6.43; 95% CI, 2.83-14.58), and low high-density lipoprotein-cholesterol (HDL-C) (OR, 2.49; 95% CI, 1.50-4.11). However, such associations were not found among boys. CONCLUSIONS: Our results suggest that insulin resistance may be independently associated with MetS, large waist circumference, high triglycerides, and low HDL-C only among girls. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/23107107/Gender_differences_in_the_association_of_insulin_resistance_with_metabolic_risk_factors_among_Korean_adolescents:_Korea_National_Health_and_Nutrition_Examination_Survey_2008_2010_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(12)00378-6 DB - PRIME DP - Unbound Medicine ER -