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Variceal recurrence, rebleeding rates and alterations in clinical and laboratory parameters following post-variceal obliteration using endoscopic sclerotherapy.
J Dig Dis. 2012 Nov; 13(11):596-600.JD

Abstract

OBJECTIVE

To study the rates of variceal recurrence and rebleeding following sclerotherapy and its effect on clinical and laboratory parameters in patients with portal hypertension.

METHODS

A total of 237 patients with portal hypertension together with esophageal variceal bleeding were included in the study. There were 138 patients with cirrhosis (group I), 42 with non-cirrhotic portal fibrosis (group II), and 57 with extrahepatic portal vein obstruction (group III). Baseline data and post-obliteration follow-up for rebleeding rates and changes in clinical and laboratory parameters were recorded.

RESULTS

In all, 106 patients in group I, 31 in group II and 43 in group III experienced obliteration of varices. The recurrence of grade II varices occurred in 17 patients (9.4%) during a mean period of 9 months. Rebleeding from varices was observed in 4 patients (3.8%) in group I and 1 (3.2%) in group II, while none in group III experienced rebleeding. There was a significant improvement in ascites, jaundice, liver status, international normalized ratio and platelet count in group I patients after variceal eradication (P < 0.05). The main cause of death in the cirrhotic patients was active liver disease but not rebleeding.

CONCLUSIONS

Following obliterative endoscopic sclerotherapy, rates of recurrence and rebleeding were significantly low when patients are kept under close observation. Disappearance of varices or reduction of variceal size improves the liver status in surviving cirrhotic patients.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Stanley Medical College Hospital, Chennai, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23107447

Citation

Krishnan, Arunkumar, et al. "Variceal Recurrence, Rebleeding Rates and Alterations in Clinical and Laboratory Parameters Following Post-variceal Obliteration Using Endoscopic Sclerotherapy." Journal of Digestive Diseases, vol. 13, no. 11, 2012, pp. 596-600.
Krishnan A, Srinivasan V, Venkataraman J. Variceal recurrence, rebleeding rates and alterations in clinical and laboratory parameters following post-variceal obliteration using endoscopic sclerotherapy. J Dig Dis. 2012;13(11):596-600.
Krishnan, A., Srinivasan, V., & Venkataraman, J. (2012). Variceal recurrence, rebleeding rates and alterations in clinical and laboratory parameters following post-variceal obliteration using endoscopic sclerotherapy. Journal of Digestive Diseases, 13(11), 596-600. https://doi.org/10.1111/j.1751-2980.2012.00633.x
Krishnan A, Srinivasan V, Venkataraman J. Variceal Recurrence, Rebleeding Rates and Alterations in Clinical and Laboratory Parameters Following Post-variceal Obliteration Using Endoscopic Sclerotherapy. J Dig Dis. 2012;13(11):596-600. PubMed PMID: 23107447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variceal recurrence, rebleeding rates and alterations in clinical and laboratory parameters following post-variceal obliteration using endoscopic sclerotherapy. AU - Krishnan,Arunkumar, AU - Srinivasan,Vijaya, AU - Venkataraman,Jayanthi, PY - 2012/10/31/entrez PY - 2012/10/31/pubmed PY - 2013/4/20/medline SP - 596 EP - 600 JF - Journal of digestive diseases JO - J Dig Dis VL - 13 IS - 11 N2 - OBJECTIVE: To study the rates of variceal recurrence and rebleeding following sclerotherapy and its effect on clinical and laboratory parameters in patients with portal hypertension. METHODS: A total of 237 patients with portal hypertension together with esophageal variceal bleeding were included in the study. There were 138 patients with cirrhosis (group I), 42 with non-cirrhotic portal fibrosis (group II), and 57 with extrahepatic portal vein obstruction (group III). Baseline data and post-obliteration follow-up for rebleeding rates and changes in clinical and laboratory parameters were recorded. RESULTS: In all, 106 patients in group I, 31 in group II and 43 in group III experienced obliteration of varices. The recurrence of grade II varices occurred in 17 patients (9.4%) during a mean period of 9 months. Rebleeding from varices was observed in 4 patients (3.8%) in group I and 1 (3.2%) in group II, while none in group III experienced rebleeding. There was a significant improvement in ascites, jaundice, liver status, international normalized ratio and platelet count in group I patients after variceal eradication (P < 0.05). The main cause of death in the cirrhotic patients was active liver disease but not rebleeding. CONCLUSIONS: Following obliterative endoscopic sclerotherapy, rates of recurrence and rebleeding were significantly low when patients are kept under close observation. Disappearance of varices or reduction of variceal size improves the liver status in surviving cirrhotic patients. SN - 1751-2980 UR - https://www.unboundmedicine.com/medline/citation/23107447/Variceal_recurrence_rebleeding_rates_and_alterations_in_clinical_and_laboratory_parameters_following_post_variceal_obliteration_using_endoscopic_sclerotherapy_ L2 - https://doi.org/10.1111/j.1751-2980.2012.00633.x DB - PRIME DP - Unbound Medicine ER -