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Effects of hypocaloric diets with different glycemic indexes on endothelial function and glycemic variability in overweight and in obese adult patients at increased cardiovascular risk.
Clin Nutr 2013; 32(3):346-52CN

Abstract

BACKGROUND & AIMS

The role of glycemic index of the diet in glucose control and cardiovascular prevention is still not clear. The aim of this study was to determine the effects of hypocaloric diets with different glycemic indexes and glycemic loads on endothelial function and glycemic variability in nondiabetic participants at increased cardiovascular risk.

METHODS

Forty nondiabetic obese participants were randomly assigned to a three-month treatment with either a low glycemic index (LGI; n=19) or high glycemic index (HGI; n=21) hypocaloric diet with similar macronutrient and fiber content. Endothelial function was measured as flow-mediated dilatation (FMD) of the brachial artery before and after dieting. In addition, 48-h continuous subcutaneous glucose monitoring was done before and after dieting in a subgroup of 24 participants.

RESULTS

The amount of weight loss after dieting was similar in both groups. The glycemic index of the diet significantly influenced the FMD (P<0.005). In particular, the change of FMD was 2.3±2.6% following the LGI diet, and -0.9±3.6% after the HGI diet (P<0.005). The mean 48-h glycemia decreased significantly after dietary treatment (P<0.05), but no significant effect of the glycemic index of the diet on results was observed. The glycemic index of the diet significantly influenced the 48-h glycemic variability measured as coefficient of variability (CV%; P<0.001). The CV% decreased after the LGI diet (from 23.5 to 20.0%) and increased after the HGI diet (from 23.6 to 26.6%). The change in percentage of FMD was inversely correlated with the change in the 48-h glycemic CV% (r=-0.45; P<0.05).

CONCLUSIONS

Endothelial function and glycemic variability ameliorate in association with the adherence to an LGI hypocaloric diet in nondiabetic obese persons.

CLINICAL TRIAL REGISTRATION NUMBER

ISRCTN56834511.

Authors+Show Affiliations

Dipartimento di Medicina Interna e Specialistica (DIMIS), Laboratorio di Nutrizione Clinica; Facoltà di Medicina, Università di Palermo, Policlinico P. Giaccone, Via del Vespro, 129, I-90127 Palermo, Italy. silbus@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

23111004

Citation

Buscemi, Silvio, et al. "Effects of Hypocaloric Diets With Different Glycemic Indexes On Endothelial Function and Glycemic Variability in Overweight and in Obese Adult Patients at Increased Cardiovascular Risk." Clinical Nutrition (Edinburgh, Scotland), vol. 32, no. 3, 2013, pp. 346-52.
Buscemi S, Cosentino L, Rosafio G, et al. Effects of hypocaloric diets with different glycemic indexes on endothelial function and glycemic variability in overweight and in obese adult patients at increased cardiovascular risk. Clin Nutr. 2013;32(3):346-52.
Buscemi, S., Cosentino, L., Rosafio, G., Morgana, M., Mattina, A., Sprini, D., ... Rini, G. B. (2013). Effects of hypocaloric diets with different glycemic indexes on endothelial function and glycemic variability in overweight and in obese adult patients at increased cardiovascular risk. Clinical Nutrition (Edinburgh, Scotland), 32(3), pp. 346-52. doi:10.1016/j.clnu.2012.10.006.
Buscemi S, et al. Effects of Hypocaloric Diets With Different Glycemic Indexes On Endothelial Function and Glycemic Variability in Overweight and in Obese Adult Patients at Increased Cardiovascular Risk. Clin Nutr. 2013;32(3):346-52. PubMed PMID: 23111004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of hypocaloric diets with different glycemic indexes on endothelial function and glycemic variability in overweight and in obese adult patients at increased cardiovascular risk. AU - Buscemi,Silvio, AU - Cosentino,Loretta, AU - Rosafio,Giuseppe, AU - Morgana,Manuela, AU - Mattina,Alessandro, AU - Sprini,Delia, AU - Verga,Salvatore, AU - Rini,Giovam Battista, Y1 - 2012/10/18/ PY - 2012/08/01/received PY - 2012/09/25/revised PY - 2012/10/12/accepted PY - 2012/11/1/entrez PY - 2012/11/1/pubmed PY - 2014/1/7/medline SP - 346 EP - 52 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 32 IS - 3 N2 - BACKGROUND & AIMS: The role of glycemic index of the diet in glucose control and cardiovascular prevention is still not clear. The aim of this study was to determine the effects of hypocaloric diets with different glycemic indexes and glycemic loads on endothelial function and glycemic variability in nondiabetic participants at increased cardiovascular risk. METHODS: Forty nondiabetic obese participants were randomly assigned to a three-month treatment with either a low glycemic index (LGI; n=19) or high glycemic index (HGI; n=21) hypocaloric diet with similar macronutrient and fiber content. Endothelial function was measured as flow-mediated dilatation (FMD) of the brachial artery before and after dieting. In addition, 48-h continuous subcutaneous glucose monitoring was done before and after dieting in a subgroup of 24 participants. RESULTS: The amount of weight loss after dieting was similar in both groups. The glycemic index of the diet significantly influenced the FMD (P<0.005). In particular, the change of FMD was 2.3±2.6% following the LGI diet, and -0.9±3.6% after the HGI diet (P<0.005). The mean 48-h glycemia decreased significantly after dietary treatment (P<0.05), but no significant effect of the glycemic index of the diet on results was observed. The glycemic index of the diet significantly influenced the 48-h glycemic variability measured as coefficient of variability (CV%; P<0.001). The CV% decreased after the LGI diet (from 23.5 to 20.0%) and increased after the HGI diet (from 23.6 to 26.6%). The change in percentage of FMD was inversely correlated with the change in the 48-h glycemic CV% (r=-0.45; P<0.05). CONCLUSIONS: Endothelial function and glycemic variability ameliorate in association with the adherence to an LGI hypocaloric diet in nondiabetic obese persons. CLINICAL TRIAL REGISTRATION NUMBER: ISRCTN56834511. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/23111004/Effects_of_hypocaloric_diets_with_different_glycemic_indexes_on_endothelial_function_and_glycemic_variability_in_overweight_and_in_obese_adult_patients_at_increased_cardiovascular_risk_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(12)00221-X DB - PRIME DP - Unbound Medicine ER -