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Subclinical coronary atherosclerosis in young adults: prevalence, characteristics, predictors with coronary computed tomography angiography.
Int J Cardiovasc Imaging. 2012 Dec; 28 Suppl 2:93-100.IJ

Abstract

The purpose of this study was to assess the characteristics and predictors of subclinical coronary atherosclerosis in young adults. The study also evaluated predictors of cardiac events. We retrospectively enrolled 914 self-referred asymptomatic subjects under the age of 45 (552 men, 362 women) who had undergone both coronary CT angiography (CCTA) and coronary artery calcium scoring. Two radiologists analyzed plaque composition and degree of stenosis. For all subjects, we evaluated clinical risk factors and investigated cardiac events. Subclinical coronary atherosclerosis was found in 86 subjects (9.4 %). Among them, 64 subjects (74.4 %) had a single coronary artery plaque. On analysis of individual segments, the most common type of plaque was non-calcified plaque (NCP) (58 %), which was found in 63 subjects (6.9 %). Significant coronary artery stenosis was found in 9 subjects (0.1 %). Predictors of subclinical coronary atherosclerosis were age, male gender, hypertension, and diabetes mellitus. Male gender, diabetes mellitus, and amount of smoking were independent predictors of NCP. High low density lipoprotein cholesterol and calcium scores were also significant predictors of stenosis. Myocardial infarction developed in 1 subject, unstable angina in 2, stable angina in 1, and death in 1 (2.45 cardiac events per 1,000 person-years of follow-up). Multivariate analysis revealed hazard ratios of 2.2 for subclinical coronary atherosclerosis, 49.17 for NCP, and 105.58 for significant stenosis. The prevalence of subclinical coronary atherosclerosis in asymptomatic young adults is not negligible. CCTA has the potential to enhance risk stratification and prediction for coronary artery disease in asymptomatic young adults.

Authors+Show Affiliations

Division of Cardiovascular Imaging, Department of Radiology, Bundang Hospital, Seoul National University, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23111407

Citation

Jin, Kwang Nam, et al. "Subclinical Coronary Atherosclerosis in Young Adults: Prevalence, Characteristics, Predictors With Coronary Computed Tomography Angiography." The International Journal of Cardiovascular Imaging, vol. 28 Suppl 2, 2012, pp. 93-100.
Jin KN, Chun EJ, Lee CH, et al. Subclinical coronary atherosclerosis in young adults: prevalence, characteristics, predictors with coronary computed tomography angiography. Int J Cardiovasc Imaging. 2012;28 Suppl 2:93-100.
Jin, K. N., Chun, E. J., Lee, C. H., Kim, J. A., Lee, M. S., & Choi, S. I. (2012). Subclinical coronary atherosclerosis in young adults: prevalence, characteristics, predictors with coronary computed tomography angiography. The International Journal of Cardiovascular Imaging, 28 Suppl 2, 93-100. https://doi.org/10.1007/s10554-012-0143-0
Jin KN, et al. Subclinical Coronary Atherosclerosis in Young Adults: Prevalence, Characteristics, Predictors With Coronary Computed Tomography Angiography. Int J Cardiovasc Imaging. 2012;28 Suppl 2:93-100. PubMed PMID: 23111407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subclinical coronary atherosclerosis in young adults: prevalence, characteristics, predictors with coronary computed tomography angiography. AU - Jin,Kwang Nam, AU - Chun,Eun Ju, AU - Lee,Chang-Hoon, AU - Kim,Jeong A, AU - Lee,Min Su, AU - Choi,Sang Il, Y1 - 2012/10/31/ PY - 2012/09/28/received PY - 2012/10/11/accepted PY - 2012/11/1/entrez PY - 2012/11/1/pubmed PY - 2013/6/13/medline SP - 93 EP - 100 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 28 Suppl 2 N2 - The purpose of this study was to assess the characteristics and predictors of subclinical coronary atherosclerosis in young adults. The study also evaluated predictors of cardiac events. We retrospectively enrolled 914 self-referred asymptomatic subjects under the age of 45 (552 men, 362 women) who had undergone both coronary CT angiography (CCTA) and coronary artery calcium scoring. Two radiologists analyzed plaque composition and degree of stenosis. For all subjects, we evaluated clinical risk factors and investigated cardiac events. Subclinical coronary atherosclerosis was found in 86 subjects (9.4 %). Among them, 64 subjects (74.4 %) had a single coronary artery plaque. On analysis of individual segments, the most common type of plaque was non-calcified plaque (NCP) (58 %), which was found in 63 subjects (6.9 %). Significant coronary artery stenosis was found in 9 subjects (0.1 %). Predictors of subclinical coronary atherosclerosis were age, male gender, hypertension, and diabetes mellitus. Male gender, diabetes mellitus, and amount of smoking were independent predictors of NCP. High low density lipoprotein cholesterol and calcium scores were also significant predictors of stenosis. Myocardial infarction developed in 1 subject, unstable angina in 2, stable angina in 1, and death in 1 (2.45 cardiac events per 1,000 person-years of follow-up). Multivariate analysis revealed hazard ratios of 2.2 for subclinical coronary atherosclerosis, 49.17 for NCP, and 105.58 for significant stenosis. The prevalence of subclinical coronary atherosclerosis in asymptomatic young adults is not negligible. CCTA has the potential to enhance risk stratification and prediction for coronary artery disease in asymptomatic young adults. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/23111407/Subclinical_coronary_atherosclerosis_in_young_adults:_prevalence_characteristics_predictors_with_coronary_computed_tomography_angiography_ L2 - https://doi.org/10.1007/s10554-012-0143-0 DB - PRIME DP - Unbound Medicine ER -