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The protective effect of recombinant human erythropoietin against cisplatin-induced renal and hepatic dysfunctions in Wistar rats.
Hum Exp Toxicol. 2013 Apr; 32(4):407-17.HE

Abstract

Cisplatin (Cisp) is one of the most effective chemotherapeutic drugs. However, the dose of Cisp is greatly limited by its toxicity. Recombinant human erythropoietin (rhEPO), a hormone that regulates hematopoiesis, has also been shown to exert tissue-protective effects. The purpose of this study was to explore the protective effect of rhEPO against Cisp-induced renal and liver dysfunctions. Adult male Wistar rats were divided into six groups of six each: control, rhEPO-alone group, Cisp-alone group and rhEPO + Cisp group (pretreatment, cotreatment and posttreatment conditions). Our results showed that Cisp-induced a marked renal and liver failure characterized by a significant decrease in body weight, organ weight and organ ratio and a significant increase in creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, G-glutamyl transferase, alkaline phosphatase, bilirubin conjugated and bilirubin total levels in serum. Histological examination showed that Cisp caused kidney alterations. rhEPO treatments restored body weight, organ weight and organ ratio as well as serum biochemical parameters changed due to Cisp exposure.

Authors+Show Affiliations

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23111886

Citation

Rjiba-Touati, K, et al. "The Protective Effect of Recombinant Human Erythropoietin Against Cisplatin-induced Renal and Hepatic Dysfunctions in Wistar Rats." Human & Experimental Toxicology, vol. 32, no. 4, 2013, pp. 407-17.
Rjiba-Touati K, Ayed-Boussema I, Belarbia A, et al. The protective effect of recombinant human erythropoietin against cisplatin-induced renal and hepatic dysfunctions in Wistar rats. Hum Exp Toxicol. 2013;32(4):407-17.
Rjiba-Touati, K., Ayed-Boussema, I., Belarbia, A., Guedri, Y., Zakhama, A., Achour, A., & Bacha, H. (2013). The protective effect of recombinant human erythropoietin against cisplatin-induced renal and hepatic dysfunctions in Wistar rats. Human & Experimental Toxicology, 32(4), 407-17. https://doi.org/10.1177/0960327111428957
Rjiba-Touati K, et al. The Protective Effect of Recombinant Human Erythropoietin Against Cisplatin-induced Renal and Hepatic Dysfunctions in Wistar Rats. Hum Exp Toxicol. 2013;32(4):407-17. PubMed PMID: 23111886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The protective effect of recombinant human erythropoietin against cisplatin-induced renal and hepatic dysfunctions in Wistar rats. AU - Rjiba-Touati,K, AU - Ayed-Boussema,I, AU - Belarbia,A, AU - Guedri,Y, AU - Zakhama,A, AU - Achour,A, AU - Bacha,H, Y1 - 2012/10/30/ PY - 2012/11/1/entrez PY - 2012/11/1/pubmed PY - 2013/11/12/medline SP - 407 EP - 17 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 32 IS - 4 N2 - Cisplatin (Cisp) is one of the most effective chemotherapeutic drugs. However, the dose of Cisp is greatly limited by its toxicity. Recombinant human erythropoietin (rhEPO), a hormone that regulates hematopoiesis, has also been shown to exert tissue-protective effects. The purpose of this study was to explore the protective effect of rhEPO against Cisp-induced renal and liver dysfunctions. Adult male Wistar rats were divided into six groups of six each: control, rhEPO-alone group, Cisp-alone group and rhEPO + Cisp group (pretreatment, cotreatment and posttreatment conditions). Our results showed that Cisp-induced a marked renal and liver failure characterized by a significant decrease in body weight, organ weight and organ ratio and a significant increase in creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, G-glutamyl transferase, alkaline phosphatase, bilirubin conjugated and bilirubin total levels in serum. Histological examination showed that Cisp caused kidney alterations. rhEPO treatments restored body weight, organ weight and organ ratio as well as serum biochemical parameters changed due to Cisp exposure. SN - 1477-0903 UR - https://www.unboundmedicine.com/medline/citation/23111886/The_protective_effect_of_recombinant_human_erythropoietin_against_cisplatin_induced_renal_and_hepatic_dysfunctions_in_Wistar_rats_ L2 - https://journals.sagepub.com/doi/10.1177/0960327111428957?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -