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Response of various indices of iron status to acute iron depletion produced in menstruating women by low iron intake and phlebotomy.
Clin Chem. 1990 Mar; 36(3):487-91.CC

Abstract

We investigated response sensitivities of indices of iron status to controlled iron depletion and repletion in 11 premenopausal women. The women were depleted of storage iron (as reflected by serum ferritin) through a combination of a low-iron diet and phlebotomy. They then consumed a diet containing 13.7 mg of iron per 2000 kcal, supplemented with either ascorbic acid or placebo (for 5 1/2 weeks) and a daily 50-mg iron supplement (for the subsequent 17 days). The relative sensitivities of different indices for detecting iron depletion were as follows: ferritin greater than % transferrin saturation greater than plasma iron greater than hemoglobin greater than hematocrit greater than zinc protoporphyrin (ZnPP) and erythrocyte protoporphyrin (EP). Ascorbic acid treatment during repletion, before iron supplementation, significantly (P less than 0.05) affected changes in hemoglobin, ZnPP, ZnPP/heme, and EP/heme. Changes in heme synthesis evidently do not occur until iron stores are depleted and, conversely, during iron repletion hematopoiesis must be satisfied before iron stores, as reflected by ferritin, increase. Thus, the use of only one index of iron status is of limited value for detecting iron depletion.

Authors+Show Affiliations

United States Department of Agriculture, Grand Forks Human Nutrition Research Center, ND 58202.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

2311219

Citation

Milne, D B., et al. "Response of Various Indices of Iron Status to Acute Iron Depletion Produced in Menstruating Women By Low Iron Intake and Phlebotomy." Clinical Chemistry, vol. 36, no. 3, 1990, pp. 487-91.
Milne DB, Gallagher SK, Nielsen FH. Response of various indices of iron status to acute iron depletion produced in menstruating women by low iron intake and phlebotomy. Clin Chem. 1990;36(3):487-91.
Milne, D. B., Gallagher, S. K., & Nielsen, F. H. (1990). Response of various indices of iron status to acute iron depletion produced in menstruating women by low iron intake and phlebotomy. Clinical Chemistry, 36(3), 487-91.
Milne DB, Gallagher SK, Nielsen FH. Response of Various Indices of Iron Status to Acute Iron Depletion Produced in Menstruating Women By Low Iron Intake and Phlebotomy. Clin Chem. 1990;36(3):487-91. PubMed PMID: 2311219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Response of various indices of iron status to acute iron depletion produced in menstruating women by low iron intake and phlebotomy. AU - Milne,D B, AU - Gallagher,S K, AU - Nielsen,F H, PY - 1990/3/1/pubmed PY - 1990/3/1/medline PY - 1990/3/1/entrez SP - 487 EP - 91 JF - Clinical chemistry JO - Clin Chem VL - 36 IS - 3 N2 - We investigated response sensitivities of indices of iron status to controlled iron depletion and repletion in 11 premenopausal women. The women were depleted of storage iron (as reflected by serum ferritin) through a combination of a low-iron diet and phlebotomy. They then consumed a diet containing 13.7 mg of iron per 2000 kcal, supplemented with either ascorbic acid or placebo (for 5 1/2 weeks) and a daily 50-mg iron supplement (for the subsequent 17 days). The relative sensitivities of different indices for detecting iron depletion were as follows: ferritin greater than % transferrin saturation greater than plasma iron greater than hemoglobin greater than hematocrit greater than zinc protoporphyrin (ZnPP) and erythrocyte protoporphyrin (EP). Ascorbic acid treatment during repletion, before iron supplementation, significantly (P less than 0.05) affected changes in hemoglobin, ZnPP, ZnPP/heme, and EP/heme. Changes in heme synthesis evidently do not occur until iron stores are depleted and, conversely, during iron repletion hematopoiesis must be satisfied before iron stores, as reflected by ferritin, increase. Thus, the use of only one index of iron status is of limited value for detecting iron depletion. SN - 0009-9147 UR - https://www.unboundmedicine.com/medline/citation/2311219/Response_of_various_indices_of_iron_status_to_acute_iron_depletion_produced_in_menstruating_women_by_low_iron_intake_and_phlebotomy_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -