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Effects of supervised exercise on lipid profiles and blood pressure control in people with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials.
Diabetes Res Clin Pract 2012; 98(3):349-60DR

Abstract

AIMS

Our study's purpose was to perform a systematic review to assess the effect of supervised exercise interventions on lipid profiles and blood pressure control.

METHODS

We searched electronic databases and selected studies that evaluated the effect of supervised exercise intervention on cardiovascular risk factors in adult people with type 2 diabetes. We used random effect models to derive weighted mean differences of exercise on lipid profiles and blood pressure control.

RESULTS

Forty-two RCTs (2808 subjects) met inclusion criteria and are included in our meta-analysis. Structured exercise was associated with a change in systolic blood pressure (SBP) of -2.42 mmHg (95% CI, -4.39 to -0.45 mmHg), diastolic blood pressure (DBP) of -2.23 mmHg (95% CI, -3.21 to -1.25 mmHg), high-density lipoprotein cholesterol (HDL-C) of 0.04 mmol/L (95% CI, 0.02-0.07 mmol/L), and low-density lipoprotein cholesterol (LDL-C) of -0.16 mmol/L (95% CI, -0.30 to -0.01 mmol/L). Heterogeneity was partially explained by age, dietary co-intervention and the duration and intensity of the exercise.

CONCLUSIONS

Supervised exercise is effective in improving blood pressure control, lowering LDL-C, and elevating HDL-C levels in people with diabetes. Physicians should recommend exercise for their adult patients with diabetes who can safely do so.

Authors+Show Affiliations

Department of Healthcare Epidemiology, Kyoto University Graduate School of Medicine and Public Health, Kyoto 606-8501, Japan. hayasino-y@umin.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

23116535

Citation

Hayashino, Yasuaki, et al. "Effects of Supervised Exercise On Lipid Profiles and Blood Pressure Control in People With Type 2 Diabetes Mellitus: a Meta-analysis of Randomized Controlled Trials." Diabetes Research and Clinical Practice, vol. 98, no. 3, 2012, pp. 349-60.
Hayashino Y, Jackson JL, Fukumori N, et al. Effects of supervised exercise on lipid profiles and blood pressure control in people with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. 2012;98(3):349-60.
Hayashino, Y., Jackson, J. L., Fukumori, N., Nakamura, F., & Fukuhara, S. (2012). Effects of supervised exercise on lipid profiles and blood pressure control in people with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Diabetes Research and Clinical Practice, 98(3), pp. 349-60. doi:10.1016/j.diabres.2012.10.004.
Hayashino Y, et al. Effects of Supervised Exercise On Lipid Profiles and Blood Pressure Control in People With Type 2 Diabetes Mellitus: a Meta-analysis of Randomized Controlled Trials. Diabetes Res Clin Pract. 2012;98(3):349-60. PubMed PMID: 23116535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of supervised exercise on lipid profiles and blood pressure control in people with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. AU - Hayashino,Yasuaki, AU - Jackson,Jeffrey L, AU - Fukumori,Norio, AU - Nakamura,Fumiaki, AU - Fukuhara,Shunichi, Y1 - 2012/10/29/ PY - 2012/05/29/received PY - 2012/08/27/revised PY - 2012/10/03/accepted PY - 2012/11/3/entrez PY - 2012/11/3/pubmed PY - 2013/5/15/medline SP - 349 EP - 60 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 98 IS - 3 N2 - AIMS: Our study's purpose was to perform a systematic review to assess the effect of supervised exercise interventions on lipid profiles and blood pressure control. METHODS: We searched electronic databases and selected studies that evaluated the effect of supervised exercise intervention on cardiovascular risk factors in adult people with type 2 diabetes. We used random effect models to derive weighted mean differences of exercise on lipid profiles and blood pressure control. RESULTS: Forty-two RCTs (2808 subjects) met inclusion criteria and are included in our meta-analysis. Structured exercise was associated with a change in systolic blood pressure (SBP) of -2.42 mmHg (95% CI, -4.39 to -0.45 mmHg), diastolic blood pressure (DBP) of -2.23 mmHg (95% CI, -3.21 to -1.25 mmHg), high-density lipoprotein cholesterol (HDL-C) of 0.04 mmol/L (95% CI, 0.02-0.07 mmol/L), and low-density lipoprotein cholesterol (LDL-C) of -0.16 mmol/L (95% CI, -0.30 to -0.01 mmol/L). Heterogeneity was partially explained by age, dietary co-intervention and the duration and intensity of the exercise. CONCLUSIONS: Supervised exercise is effective in improving blood pressure control, lowering LDL-C, and elevating HDL-C levels in people with diabetes. Physicians should recommend exercise for their adult patients with diabetes who can safely do so. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/23116535/Effects_of_supervised_exercise_on_lipid_profiles_and_blood_pressure_control_in_people_with_type_2_diabetes_mellitus:_a_meta_analysis_of_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(12)00371-3 DB - PRIME DP - Unbound Medicine ER -