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A comparison of albumin and urea as reference markers in bronchoalveolar lavage fluid from patients with interstitial lung disease.
Eur Respir J. 1990 Feb; 3(2):152-6.ER

Abstract

Lavage fluids were investigated for 67 subjects in 6 groups: 12 with active sarcoidosis, 8 with inactive sarcoidosis, 17 with pigeon breeder's disease, 10 asymptomatic pigeon breeders, 12 with idiopathic pulmonary fibrosis (IPF) and 8 normal subjects. Albumin and urea per ml of bronchoalveolar lavage fluid (BALF) were determined for each subject together with percentage return of fluid (BAL%). Novel assay systems were employed to measure urea and albumin and these were compared with existing analytical techniques. When compared with the control group, we found that urea per ml of BALF was not statistically different for all other groups, except those with pigeon breeder's disease who had significantly raised levels. For albumin, however, three groups had significantly higher levels than the controls, namely those with active sarcoidosis, pigeon breeder's disease and IPF. BAL% return showed no significant differences for any group when compared with the controls. We conclude that since albumin is significantly raised in most patients with interstitial lung disease it does not represent a suitable marker for the quantitation of reactive proteins in BALF. Urea shows much less variability between groups than does albumin, and hence in the absence of a proven alternative represents the most reliable estimate available of epithelial lining fluid dilution during the lavage procedure, providing dwell time is kept to a minimum.

Authors+Show Affiliations

Department of Medical Microbiology, University of Wales College of Medicine, Cardiff, U.K.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2311740

Citation

Jones, K P., et al. "A Comparison of Albumin and Urea as Reference Markers in Bronchoalveolar Lavage Fluid From Patients With Interstitial Lung Disease." The European Respiratory Journal, vol. 3, no. 2, 1990, pp. 152-6.
Jones KP, Edwards JH, Reynolds SP, et al. A comparison of albumin and urea as reference markers in bronchoalveolar lavage fluid from patients with interstitial lung disease. Eur Respir J. 1990;3(2):152-6.
Jones, K. P., Edwards, J. H., Reynolds, S. P., Peters, T. J., & Davies, B. H. (1990). A comparison of albumin and urea as reference markers in bronchoalveolar lavage fluid from patients with interstitial lung disease. The European Respiratory Journal, 3(2), 152-6.
Jones KP, et al. A Comparison of Albumin and Urea as Reference Markers in Bronchoalveolar Lavage Fluid From Patients With Interstitial Lung Disease. Eur Respir J. 1990;3(2):152-6. PubMed PMID: 2311740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of albumin and urea as reference markers in bronchoalveolar lavage fluid from patients with interstitial lung disease. AU - Jones,K P, AU - Edwards,J H, AU - Reynolds,S P, AU - Peters,T J, AU - Davies,B H, PY - 1990/2/1/pubmed PY - 1990/2/1/medline PY - 1990/2/1/entrez SP - 152 EP - 6 JF - The European respiratory journal JO - Eur Respir J VL - 3 IS - 2 N2 - Lavage fluids were investigated for 67 subjects in 6 groups: 12 with active sarcoidosis, 8 with inactive sarcoidosis, 17 with pigeon breeder's disease, 10 asymptomatic pigeon breeders, 12 with idiopathic pulmonary fibrosis (IPF) and 8 normal subjects. Albumin and urea per ml of bronchoalveolar lavage fluid (BALF) were determined for each subject together with percentage return of fluid (BAL%). Novel assay systems were employed to measure urea and albumin and these were compared with existing analytical techniques. When compared with the control group, we found that urea per ml of BALF was not statistically different for all other groups, except those with pigeon breeder's disease who had significantly raised levels. For albumin, however, three groups had significantly higher levels than the controls, namely those with active sarcoidosis, pigeon breeder's disease and IPF. BAL% return showed no significant differences for any group when compared with the controls. We conclude that since albumin is significantly raised in most patients with interstitial lung disease it does not represent a suitable marker for the quantitation of reactive proteins in BALF. Urea shows much less variability between groups than does albumin, and hence in the absence of a proven alternative represents the most reliable estimate available of epithelial lining fluid dilution during the lavage procedure, providing dwell time is kept to a minimum. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/2311740/A_comparison_of_albumin_and_urea_as_reference_markers_in_bronchoalveolar_lavage_fluid_from_patients_with_interstitial_lung_disease_ L2 - http://www.diseaseinfosearch.org/result/3844 DB - PRIME DP - Unbound Medicine ER -