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Determination of non-steroidal anti-inflammatory drugs in urine by hollow-fiber liquid membrane-protected solid-phase microextraction based on sol-gel fiber coating.

Abstract

A new rapid, simple and effective cleanup procedure is demonstrated for the determination of ibuprofen, naproxen and diclofenac in urine samples by using hollow-fiber liquid membrane-protected solid-phase microextraction (HFLM-SPME) based on sol-gel technique and gas chromatography-flame ionization detector (GC-FID). In this technique, a sol-gel coated fiber was protected with a length of porous polypropylene hollow fiber membrane which was filled with water-immiscible organic phase. Subsequently the whole device was immersed into urine sample for extraction. Poly(ethylene glycol) (PEG) grafted onto multi-walled carbon nanotubes (PEG-g-MWCNTs) was used as extraction phase to prepare the sol-gel SPME fiber. Important parameters influencing the extraction efficiency such as desorption temperature and time, organic solvent, extraction temperature and time, pH, stirring speed and salt effect were investigated and optimized. Under the optimal conditions, the method detection limits (S/N=3) were in the range of 0.03-0.07ngmL(-1) and the limits of quantification (S/N=10) between 0.08 and 0.15ngmL(-1). Relative standard deviations for intra-day and inter-day precisions were 4.8-9.0% and 4.9-8.1%, respectively. Subsequently, the method was successfully applied to human urine fractions after administration of ibuprofen, naproxen and diclofenac.

Authors+Show Affiliations

Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Iran. asyazdi@um.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23122403

Citation

Sarafraz-Yazdi, Ali, et al. "Determination of Non-steroidal Anti-inflammatory Drugs in Urine By Hollow-fiber Liquid Membrane-protected Solid-phase Microextraction Based On Sol-gel Fiber Coating." Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 908, 2012, pp. 67-75.
Sarafraz-Yazdi A, Amiri A, Rounaghi G, et al. Determination of non-steroidal anti-inflammatory drugs in urine by hollow-fiber liquid membrane-protected solid-phase microextraction based on sol-gel fiber coating. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;908:67-75.
Sarafraz-Yazdi, A., Amiri, A., Rounaghi, G., & Eshtiagh-Hosseini, H. (2012). Determination of non-steroidal anti-inflammatory drugs in urine by hollow-fiber liquid membrane-protected solid-phase microextraction based on sol-gel fiber coating. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 908, 67-75. https://doi.org/10.1016/j.jchromb.2012.09.040
Sarafraz-Yazdi A, et al. Determination of Non-steroidal Anti-inflammatory Drugs in Urine By Hollow-fiber Liquid Membrane-protected Solid-phase Microextraction Based On Sol-gel Fiber Coating. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:67-75. PubMed PMID: 23122403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of non-steroidal anti-inflammatory drugs in urine by hollow-fiber liquid membrane-protected solid-phase microextraction based on sol-gel fiber coating. AU - Sarafraz-Yazdi,Ali, AU - Amiri,Amirhassan, AU - Rounaghi,Gholamhossein, AU - Eshtiagh-Hosseini,Hossein, Y1 - 2012/10/06/ PY - 2012/05/14/received PY - 2012/09/15/revised PY - 2012/09/21/accepted PY - 2012/11/6/entrez PY - 2012/11/6/pubmed PY - 2013/5/10/medline SP - 67 EP - 75 JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences JO - J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. VL - 908 N2 - A new rapid, simple and effective cleanup procedure is demonstrated for the determination of ibuprofen, naproxen and diclofenac in urine samples by using hollow-fiber liquid membrane-protected solid-phase microextraction (HFLM-SPME) based on sol-gel technique and gas chromatography-flame ionization detector (GC-FID). In this technique, a sol-gel coated fiber was protected with a length of porous polypropylene hollow fiber membrane which was filled with water-immiscible organic phase. Subsequently the whole device was immersed into urine sample for extraction. Poly(ethylene glycol) (PEG) grafted onto multi-walled carbon nanotubes (PEG-g-MWCNTs) was used as extraction phase to prepare the sol-gel SPME fiber. Important parameters influencing the extraction efficiency such as desorption temperature and time, organic solvent, extraction temperature and time, pH, stirring speed and salt effect were investigated and optimized. Under the optimal conditions, the method detection limits (S/N=3) were in the range of 0.03-0.07ngmL(-1) and the limits of quantification (S/N=10) between 0.08 and 0.15ngmL(-1). Relative standard deviations for intra-day and inter-day precisions were 4.8-9.0% and 4.9-8.1%, respectively. Subsequently, the method was successfully applied to human urine fractions after administration of ibuprofen, naproxen and diclofenac. SN - 1873-376X UR - https://www.unboundmedicine.com/medline/citation/23122403/Determination_of_non_steroidal_anti_inflammatory_drugs_in_urine_by_hollow_fiber_liquid_membrane_protected_solid_phase_microextraction_based_on_sol_gel_fiber_coating_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1570-0232(12)00582-X DB - PRIME DP - Unbound Medicine ER -