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Neurobiological markers of exercise-related brain plasticity in older adults.
Brain Behav Immun. 2013 Feb; 28:90-9.BB

Abstract

The current study examined how a randomized one-year aerobic exercise program for healthy older adults would affect serum levels of brain-derived neurotrophic factor (BDNF), insulin-like growth factor type 1 (IGF-1), and vascular endothelial growth factor (VEGF) - putative markers of exercise-induced benefits on brain function. The study also examined whether (a) change in the concentration of these growth factors was associated with alterations in functional connectivity following exercise, and (b) the extent to which pre-intervention growth factor levels were associated with training-related changes in functional connectivity. In 65 participants (mean age=66.4), we found that although there were no group-level changes in growth factors as a function of the intervention, increased temporal lobe connectivity between the bilateral parahippocampus and the bilateral middle temporal gyrus was associated with increased BDNF, IGF-1, and VEGF for an aerobic walking group but not for a non-aerobic control group, and greater pre-intervention VEGF was associated with greater training-related increases in this functional connection. Results are consistent with animal models of exercise and the brain, but are the first to show in humans that exercise-induced increases in temporal lobe functional connectivity are associated with changes in growth factors and may be augmented by greater baseline VEGF.

Authors+Show Affiliations

The University of Iowa, Department of Psychology, IA 52242, United States. michelle-voss@uiowa.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23123199

Citation

Voss, Michelle W., et al. "Neurobiological Markers of Exercise-related Brain Plasticity in Older Adults." Brain, Behavior, and Immunity, vol. 28, 2013, pp. 90-9.
Voss MW, Erickson KI, Prakash RS, et al. Neurobiological markers of exercise-related brain plasticity in older adults. Brain Behav Immun. 2013;28:90-9.
Voss, M. W., Erickson, K. I., Prakash, R. S., Chaddock, L., Kim, J. S., Alves, H., Szabo, A., Phillips, S. M., Wójcicki, T. R., Mailey, E. L., Olson, E. A., Gothe, N., Vieira-Potter, V. J., Martin, S. A., Pence, B. D., Cook, M. D., Woods, J. A., McAuley, E., & Kramer, A. F. (2013). Neurobiological markers of exercise-related brain plasticity in older adults. Brain, Behavior, and Immunity, 28, 90-9. https://doi.org/10.1016/j.bbi.2012.10.021
Voss MW, et al. Neurobiological Markers of Exercise-related Brain Plasticity in Older Adults. Brain Behav Immun. 2013;28:90-9. PubMed PMID: 23123199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurobiological markers of exercise-related brain plasticity in older adults. AU - Voss,Michelle W, AU - Erickson,Kirk I, AU - Prakash,Ruchika Shaurya, AU - Chaddock,Laura, AU - Kim,Jennifer S, AU - Alves,Heloisa, AU - Szabo,Amanda, AU - Phillips,Siobhan M, AU - Wójcicki,Thomas R, AU - Mailey,Emily L, AU - Olson,Erin A, AU - Gothe,Neha, AU - Vieira-Potter,Victoria J, AU - Martin,Stephen A, AU - Pence,Brandt D, AU - Cook,Marc D, AU - Woods,Jeffrey A, AU - McAuley,Edward, AU - Kramer,Arthur F, Y1 - 2012/11/02/ PY - 2012/06/20/received PY - 2012/10/24/revised PY - 2012/10/24/accepted PY - 2012/11/6/entrez PY - 2012/11/6/pubmed PY - 2013/7/3/medline SP - 90 EP - 9 JF - Brain, behavior, and immunity JO - Brain Behav. Immun. VL - 28 N2 - The current study examined how a randomized one-year aerobic exercise program for healthy older adults would affect serum levels of brain-derived neurotrophic factor (BDNF), insulin-like growth factor type 1 (IGF-1), and vascular endothelial growth factor (VEGF) - putative markers of exercise-induced benefits on brain function. The study also examined whether (a) change in the concentration of these growth factors was associated with alterations in functional connectivity following exercise, and (b) the extent to which pre-intervention growth factor levels were associated with training-related changes in functional connectivity. In 65 participants (mean age=66.4), we found that although there were no group-level changes in growth factors as a function of the intervention, increased temporal lobe connectivity between the bilateral parahippocampus and the bilateral middle temporal gyrus was associated with increased BDNF, IGF-1, and VEGF for an aerobic walking group but not for a non-aerobic control group, and greater pre-intervention VEGF was associated with greater training-related increases in this functional connection. Results are consistent with animal models of exercise and the brain, but are the first to show in humans that exercise-induced increases in temporal lobe functional connectivity are associated with changes in growth factors and may be augmented by greater baseline VEGF. SN - 1090-2139 UR - https://www.unboundmedicine.com/medline/citation/23123199/Neurobiological_markers_of_exercise_related_brain_plasticity_in_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-1591(12)00483-7 DB - PRIME DP - Unbound Medicine ER -