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Comparative metal distribution in scalp hair of Pakistani and Irish referents and diabetes mellitus patients.
Clin Chim Acta 2013; 415:207-14CC

Abstract

BACKGROUND

The essential metals, chromium (Cr), magnesium (Mg), manganese (Mn) and zinc (Zn), are necessary for many metabolic processes and their homeostasis is crucial for life. The toxic metals, cadmium (Cd) and lead (Pb), have no beneficial role in human metabolism. The aim of this study was to investigate the levels of Cd, Cr, Mg, Mn, Pb, and Zn in scalp hair samples of type 2 diabetes mellitus patients of both genders, ages ranging from 30 to 50 y, and belong to urban areas of Ireland and Pakistan. For comparison purposes, age matched non-diabetic subjects of both countries were selected as referents.

METHODS

The concentrations of metals in scalp hair samples were measured by inductively coupled plasma atomic emission spectrophotometer and atomic absorption spectrophotometer after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked by conventional wet-acid-digestion method and using certified reference materials.

RESULTS

The mean values of Cd and Pb were significantly higher in scalp hair samples of both Pakistani and Irish diabetic patients as compared to referents of both countries (P<0.001). In contrast, lower Cr, Mg, Mn, and Zn (P<0.01) concentrations were detected in scalp hair derived from patients with type 2 diabetes versus healthy subjects of both countries.

CONCLUSION

This study showed that, increased toxic elements and decreased essential elements are associated with diabetes mellitus. Therefore, these elements may play a role in the development and pathogenesis of diabetes mellitus.

Authors+Show Affiliations

Mechanical & Manufacturing Engineering, Dublin City University, Dublin, Ireland. hassanimranafridi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23123286

Citation

Afridi, Hassan Imran, et al. "Comparative Metal Distribution in Scalp Hair of Pakistani and Irish Referents and Diabetes Mellitus Patients." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 415, 2013, pp. 207-14.
Afridi HI, Kazi TG, Brabazon D, et al. Comparative metal distribution in scalp hair of Pakistani and Irish referents and diabetes mellitus patients. Clin Chim Acta. 2013;415:207-14.
Afridi, H. I., Kazi, T. G., Brabazon, D., Naher, S., & Talpur, F. N. (2013). Comparative metal distribution in scalp hair of Pakistani and Irish referents and diabetes mellitus patients. Clinica Chimica Acta; International Journal of Clinical Chemistry, 415, pp. 207-14. doi:10.1016/j.cca.2012.10.029.
Afridi HI, et al. Comparative Metal Distribution in Scalp Hair of Pakistani and Irish Referents and Diabetes Mellitus Patients. Clin Chim Acta. 2013 Jan 16;415:207-14. PubMed PMID: 23123286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative metal distribution in scalp hair of Pakistani and Irish referents and diabetes mellitus patients. AU - Afridi,Hassan Imran, AU - Kazi,Tasneem Gul, AU - Brabazon,Dermot, AU - Naher,Sumsun, AU - Talpur,Farah Naz, Y1 - 2012/11/01/ PY - 2011/11/22/received PY - 2012/08/21/revised PY - 2012/10/15/accepted PY - 2012/11/6/entrez PY - 2012/11/6/pubmed PY - 2013/6/1/medline SP - 207 EP - 14 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 415 N2 - BACKGROUND: The essential metals, chromium (Cr), magnesium (Mg), manganese (Mn) and zinc (Zn), are necessary for many metabolic processes and their homeostasis is crucial for life. The toxic metals, cadmium (Cd) and lead (Pb), have no beneficial role in human metabolism. The aim of this study was to investigate the levels of Cd, Cr, Mg, Mn, Pb, and Zn in scalp hair samples of type 2 diabetes mellitus patients of both genders, ages ranging from 30 to 50 y, and belong to urban areas of Ireland and Pakistan. For comparison purposes, age matched non-diabetic subjects of both countries were selected as referents. METHODS: The concentrations of metals in scalp hair samples were measured by inductively coupled plasma atomic emission spectrophotometer and atomic absorption spectrophotometer after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked by conventional wet-acid-digestion method and using certified reference materials. RESULTS: The mean values of Cd and Pb were significantly higher in scalp hair samples of both Pakistani and Irish diabetic patients as compared to referents of both countries (P<0.001). In contrast, lower Cr, Mg, Mn, and Zn (P<0.01) concentrations were detected in scalp hair derived from patients with type 2 diabetes versus healthy subjects of both countries. CONCLUSION: This study showed that, increased toxic elements and decreased essential elements are associated with diabetes mellitus. Therefore, these elements may play a role in the development and pathogenesis of diabetes mellitus. SN - 1873-3492 UR - https://www.unboundmedicine.com/medline/citation/23123286/Comparative_metal_distribution_in_scalp_hair_of_Pakistani_and_Irish_referents_and_diabetes_mellitus_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(12)00496-2 DB - PRIME DP - Unbound Medicine ER -