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Essential oil variation in the populations of Artemisia spicigera from northwest of Iran: chemical composition and antibacterial activity.
Pharm Biol. 2013 Feb; 51(2):246-52.PB

Abstract

CONTEXT

Artemisia spicigera C. Koch (Asteraceae) is a perennial shrubby herb and is generally distributed in Armenia, Iran, and Middle Anatolia. This species traditionally has been used in medicines.

OBJECTIVE

The aim of this research is to study the chemical composition and antibacterial activity of essential oils from Artemisia spicigera populations in northwest of Iran.

MATERIALS AND METHODS

The essential oil of A. spicigera was obtained by hydrodistillation from eight populations collected from different regions of East Azerbaijan and West Azerbaijan provinces (Iran) and analyzed by gas chromatography-mass spectrometry (GC-MS). The antibacterial activity of the oils was investigated against four Gram-positive and four Gram-negative bacteria using MIC determinations and the agar-gel diffusion method.

RESULTS

Fourteen compounds were identified as the main components of the essential oils and the most abundant constituents are 1,8-cineole, camphor, α-thujone, camphene, β-thujone and p-cymene. Essential oil of population No. 1 showed the highest activity against Escherichia coli, Enterobacter aerogenes, Serratia marcescens and Staphylococcus aureus but the highest activity against St. saprophyticus, Bacillus megaterium, and B. cereus was found with population No. 6 and for Citrobacter amalonaficus with population No. 5. MIC values of essential oils ranged from 6 µg/mL against Bacillus megaterium to 12 µg/mL against Citrobacter amalonaficus.

DISCUSSION

This study demonstrates the occurrence of 1,8-cineole/camphor/camphene chemotype of A. spicigera but there is also significant chemical variation between the studied populations. The findings showed the studied oils have good antibacterial activity, and thus potential to be used as natural health products.

Authors+Show Affiliations

Department of Biology, Laboratory of Plant Cell Biology, Bu-Ali Sina University, Hamedan, Iran. chehregani@basu.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23126238

Citation

Chehregani, Abdolkarim, et al. "Essential Oil Variation in the Populations of Artemisia Spicigera From Northwest of Iran: Chemical Composition and Antibacterial Activity." Pharmaceutical Biology, vol. 51, no. 2, 2013, pp. 246-52.
Chehregani A, Atri M, Yousefi S, et al. Essential oil variation in the populations of Artemisia spicigera from northwest of Iran: chemical composition and antibacterial activity. Pharm Biol. 2013;51(2):246-52.
Chehregani, A., Atri, M., Yousefi, S., Albooyeh, Z., & Mohsenzadeh, F. (2013). Essential oil variation in the populations of Artemisia spicigera from northwest of Iran: chemical composition and antibacterial activity. Pharmaceutical Biology, 51(2), 246-52. https://doi.org/10.3109/13880209.2012.717631
Chehregani A, et al. Essential Oil Variation in the Populations of Artemisia Spicigera From Northwest of Iran: Chemical Composition and Antibacterial Activity. Pharm Biol. 2013;51(2):246-52. PubMed PMID: 23126238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Essential oil variation in the populations of Artemisia spicigera from northwest of Iran: chemical composition and antibacterial activity. AU - Chehregani,Abdolkarim, AU - Atri,Morteza, AU - Yousefi,Somayeh, AU - Albooyeh,Zahra, AU - Mohsenzadeh,Fariba, Y1 - 2012/11/06/ PY - 2012/11/7/entrez PY - 2012/11/7/pubmed PY - 2013/6/29/medline SP - 246 EP - 52 JF - Pharmaceutical biology JO - Pharm Biol VL - 51 IS - 2 N2 - CONTEXT: Artemisia spicigera C. Koch (Asteraceae) is a perennial shrubby herb and is generally distributed in Armenia, Iran, and Middle Anatolia. This species traditionally has been used in medicines. OBJECTIVE: The aim of this research is to study the chemical composition and antibacterial activity of essential oils from Artemisia spicigera populations in northwest of Iran. MATERIALS AND METHODS: The essential oil of A. spicigera was obtained by hydrodistillation from eight populations collected from different regions of East Azerbaijan and West Azerbaijan provinces (Iran) and analyzed by gas chromatography-mass spectrometry (GC-MS). The antibacterial activity of the oils was investigated against four Gram-positive and four Gram-negative bacteria using MIC determinations and the agar-gel diffusion method. RESULTS: Fourteen compounds were identified as the main components of the essential oils and the most abundant constituents are 1,8-cineole, camphor, α-thujone, camphene, β-thujone and p-cymene. Essential oil of population No. 1 showed the highest activity against Escherichia coli, Enterobacter aerogenes, Serratia marcescens and Staphylococcus aureus but the highest activity against St. saprophyticus, Bacillus megaterium, and B. cereus was found with population No. 6 and for Citrobacter amalonaficus with population No. 5. MIC values of essential oils ranged from 6 µg/mL against Bacillus megaterium to 12 µg/mL against Citrobacter amalonaficus. DISCUSSION: This study demonstrates the occurrence of 1,8-cineole/camphor/camphene chemotype of A. spicigera but there is also significant chemical variation between the studied populations. The findings showed the studied oils have good antibacterial activity, and thus potential to be used as natural health products. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/23126238/Essential_oil_variation_in_the_populations_of_Artemisia_spicigera_from_northwest_of_Iran:_chemical_composition_and_antibacterial_activity_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2012.717631 DB - PRIME DP - Unbound Medicine ER -